6-phosphogluconate dehydrogenase NADP-binding
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
TonB-dependent receptor-like beta-barrel
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
Signal transduction histidine kinase subgroup 2 dimerisation and phosphoacceptor
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Prokaryotic-type class I peptide chain release factors
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Major facilitator superfamily (MFS) profile
Histidine phosphotransferase ChpT C-terminal
Outer membrane protein beta-barrel domain-containing protein
Biopterin-dependent aromatic amino acid hydroxylase family profile
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Polymerase/histidinol phosphatase N-terminal
Anthranilate synthase component I N-terminal
Bacterial type II secretion system protein E
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Glycosyl-hydrolase 97 C-terminal oligomerisation
Tryptophan synthase beta chain-like PALP
Glucosamine/galactosamine-6-phosphate isomerase
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
Poly-beta-hydroxybutyrate polymerase N-terminal
Lysozyme inhibitor LprI N-terminal domain-containing protein
RNA binding; important for wobble base 34 recognition
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Polypeptide-transport-associated ShlB-type domain-containing protein
Organic solvent tolerance-like N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
YbgF trimerisation domain-containing protein
Cytochrome c-type biogenesis protein CcmF C-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Quercetin 2,3-dioxygenase C-terminal cupin
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Transcription elongation factor GreA/GreB C-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Type IV secretion system coupling protein TraD DNA-binding
Peptidase S9 prolyl oligopeptidase catalytic
RND efflux pump membrane fusion protein barrel-sandwich
Beta-hexosaminidase bacterial type N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Cupin 2 conserved barrel domain-containing protein
Aminoacyl-transfer RNA synthetases class-II family profile
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Phosphoribosylformylglycinamidine synthase linker
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Heavy-metal-associated domain-containing protein
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
Helix-hairpin-helix DNA-binding motif class 1
Terminase large subunit gp17-like C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Type ISP restriction-modification enzyme LLaBIII C-terminal specificity
Disulphide bond isomerase DsbC/G N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Glycosyltransferase subfamily 4-like N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Small ribosomal subunit protein uS4 N-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Tetrahydrodipicolinate-N-succinyltransferase chain A
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Pseudouridine synthase I TruA alpha/beta
Alpha-D-phosphohexomutase alpha/beta/alpha
Alginate export domain-containing protein
PhoD-like phosphatase metallophosphatase
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
C-type lysozyme inhibitor domain-containing protein
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Cytochrome C biogenesis protein transmembrane
Thiol:disulfide interchange protein DsbD N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Bacterial surface antigen (D15) domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate
Transcription elongation factor GreA/GreB N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Glycosyl hydrolases family 2 sugar binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
Exonuclease VII large subunit C-terminal
Phosphate starvation-inducible protein PsiF
Resolvase/invertase-type recombinase catalytic
O-(5'-phospho-DNA)-tyrosine intermediate
Transposase IS116/IS110/IS902 C-terminal
Cation-transporting P-type ATPase N-terminal
Beta/gamma crystallin 'Greek key' domain-containing protein
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
tRNA pseudouridylate synthase B C-terminal
Arginine biosynthesis bifunctional protein ArgJ
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
N-acetylneuraminic acid synthase N-terminal
Peptidase M17 leucyl aminopeptidase N-terminal
Translation elongation factor P/YeiP central
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Extracellular exo-alpha-(1->5)-L-arabinofuranosidase
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Beta-xylosidase C-terminal Concanavalin A-like
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
General stress protein FMN-binding split barrel
Microcin J25-processing protein McjB C-terminal
DNA mismatch repair proteins mutS family
Thioredoxin-like fold domain-containing protein
Pyridoxamine 5'-phosphate oxidase putative
Thymidylate synthase/dCMP hydroxymethylase
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
peptide-methionine (R)-S-oxide reductase
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Membrane fusion protein biotin-lipoyl like
RNA 3'-terminal phosphate cyclase insert
Activator of Hsp90 ATPase homologue 1-like C-terminal
Interaction with polymerase core subunit RpoC
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Putative auto-transporter adhesin head GIN
Methionyl-tRNA synthetase anticodon-binding
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase-like C-terminal
DNA topoisomerase I catalytic core eukaryotic-type
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
DNA-directed DNA polymerase family A palm
5-glutamyl coenzyme A thioester intermediate
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Superoxide dismutase copper/zinc binding
ABC-type transport auxiliary lipoprotein component
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Endoribonuclease L-PSP/chorismate mutase-like
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
N6 adenine-specific DNA methyltransferase N-terminal
N-sulphoglucosamine sulphohydrolase C-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Glycine zipper 2TM domain-containing protein
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Penicillin-binding protein transpeptidase
Myo-inositol-1-phosphate synthase GAPDH-like
Electron transfer via tryptophanyl radical
Signal transduction histidine kinase HWE region
O-(3'-phospho-DNA)-tyrosine intermediate
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Glycoside hydrolase GH146 substrate-binding
Glycoside hydrolase GH146 substrate-binding domain-containing protein
L,D-transpeptidase catalytic domain-containing protein
Plays an important role in substrate specificity
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Peptide methionine sulphoxide reductase MsrA
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Survival protein SurE-like phosphatase/nucleotidase
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Reversibly protonated during proton transport
Histidine-specific methyltransferase SAM-dependent
YbaK/aminoacyl-tRNA synthetase-associated
Proton acceptor; for glutaminase activity
Glycine cleavage T-protein C-terminal barrel
NAD(P) transhydrogenase alpha subunit C-terminal
Moves into active site upon enzyme activation, plays a role in electron transfer
CDP-alcohol phosphatidyltransferase C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
SGNH hydrolase-type esterase domain-containing protein
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
S-adenosyl-L-homocysteine hydrolase NAD binding
NADH:ubiquinone oxidoreductase 30kDa subunit
Type II secretion system protein GspI C-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Glycoside hydrolase family 42 N-terminal
Alpha galactosidase C-terminal beta sandwich
Large ribosomal subunit protein uL15/eL18
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Proline utilization A proline dehydrogenase N-terminal
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
PHA accumulation regulator DNA-binding N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Glycoside hydrolase family 31 N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Dienelactone hydrolase domain-containing protein
N-end rule aminoacyl transferase C-terminal
Lactate utilization protein B C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Important for beta-aspartyl-AMP intermediate formation
EfeO-type cupredoxin-like domain-containing protein
FAD-dependent oxidoreductase 2 FAD binding
Calcium-dependent phosphoinositide phospholipase C
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Heme-copper oxidase subunit III family profile
Gp5/Type VI secretion system Vgr protein OB-fold
Could be important to modulate the pK values of the two catalytic cysteine residues
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Prepilin type IV endopeptidase peptidase
Charge relay system; for autoendoproteolytic cleavage activity
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Probable periplasmic serine endoprotease DegP-like
Cell wall hydrolase SleB domain-containing protein
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
RNA 2-O ribose methyltransferase substrate binding
Secretin/TonB short N-terminal domain-containing protein
Glycosyl transferase family 3 N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Cobaltochelatase subunit CobS N-terminal
S-adenosylmethionine-dependent methyltransferase
CobB/CobQ-like glutamine amidotransferase
Peptidase M14 carboxypeptidase A domain-containing protein
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Alanyl-transfer RNA synthetases family profile
DNA replication/recombination mediator RecO N-terminal
DNA translocase FtsK 4TM region domain-containing protein
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Pyruvate phosphate dikinase AMP/ATP-binding
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Phosphatidic acid phosphatase type 2/haloperoxidase
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Nitrite/Sulfite reductase ferredoxin-like
SUF system FeS cluster assembly SufBD N-terminal
Protein O-mannosyl-transferase C-terminal four TM
Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein
Gellan polysaccharide biosynthesis protein GelF
Outer membrane protein assembly factor BamD
Release factor glutamine methyltransferase N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Right handed beta helix domain-containing protein
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Large ribosomal subunit protein uL6 alpha-beta
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Polysaccharide chain length determinant N-terminal
Large ribosomal subunit protein uL2 C-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Essential for prephenate dehydratase activity
6-phosphogluconate dehydrogenase C-terminal
Glycosyl hydrolase family 98 putative carbohydrate-binding module
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Signal recognition particle SRP54 helical bundle
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Increases nucleophilicity of active site Cys