Major facilitator superfamily (MFS) profile
Inosine/uridine-preferring nucleoside hydrolase
Quercetin 2,3-dioxygenase C-terminal cupin
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cytochrome b561 bacterial/Ni-hydrogenase
Glycosyltransferase subfamily 4-like N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Polymerase/histidinol phosphatase N-terminal
Histidine-specific methyltransferase SAM-dependent
L,D-transpeptidase catalytic domain-containing protein
Pyridoxamine 5'-phosphate oxidase putative
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
ESX-1 secretion-associated protein EspB PE
2,4-diaminopentanoate dehydrogenase C-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
EfeO-type cupredoxin-like domain-containing protein
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Activator of Hsp90 ATPase homologue 1-like C-terminal
Solute-binding protein family 3/N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Ribose-phosphate pyrophosphokinase N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Moves into active site upon enzyme activation, plays a role in electron transfer
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Methionyl-tRNA synthetase anticodon-binding
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Schiff-base intermediate with substrate; via topaquinone
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Carbamoyl-phosphate synthase small subunit N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Essential for prephenate dehydratase activity
Bacterial bifunctional deaminase-reductase C-terminal
Acetyl-CoA hydrolase/transferase C-terminal
Alpha-glycerophosphate oxidase C-terminal
Translation elongation factor P/YeiP central
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Putative oxidoreductase/dehydrogenase Rossmann-like
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Bacterial type II secretion system protein E
Important for substrate specificity; cannot use PPi as phosphoryl donor
Pyrimidine nucleoside phosphorylase C-terminal
CobB/CobQ-like glutamine amidotransferase
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Endoribonuclease L-PSP/chorismate mutase-like
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Reversibly protonated during proton transport
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Thiolase-like protein type 1 additional C-terminal
Threonine/serine exporter-like N-terminal
DNA polymerase III delta subunit C-terminal
Proton acceptor; for glutaminase activity
UDP-glucose/GDP-mannose dehydrogenase C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Membrane insertase YidC/Oxa/ALB C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Resolvase/invertase-type recombinase catalytic
Prokaryotic-type class I peptide chain release factors
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Cytochrome oxidase subunit II copper A binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Methylguanine DNA methyltransferase ribonuclease-like
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Glycine cleavage T-protein C-terminal barrel
Could play a key role in the communication between the regulatory and the substrate sites
Chromosomal replication initiator DnaA C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Schiff-base intermediate with acetaldehyde
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Ionotropic glutamate receptor C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
SUF system FeS cluster assembly SufBD N-terminal
Glutamate synthase alpha subunit C-terminal
Small ribosomal subunit protein uS4 N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Anti-sigma-D factor RsdA sigma factor binding region
Large ribosomal subunit protein uL2 C-terminal
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Penicillin-binding protein transpeptidase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Helix-hairpin-helix DNA-binding motif class 1
Pyruvate dehydrogenase E1 component middle
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
NADH:ubiquinone oxidoreductase intermediate-associated protein 30
PknH-like extracellular domain-containing protein
Transmembrane alanine and glycine rich protein
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
DNA replication/recombination mediator RecO N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
Saccharopine dehydrogenase-like C-terminal
LPXTG cell wall anchor domain-containing protein
Formamidopyrimidine-DNA glycosylase catalytic
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Transglycosylase SLT domain-containing protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Phosphodiester glycosidase domain-containing protein
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
NADH:ubiquinone oxidoreductase-like 20kDa subunit
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Polysaccharide biosynthesis protein C-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Removed in mature form; by autocatalysis
Tryptophan synthase beta chain-like PALP
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Antitoxin Xre/MbcA/ParS-like toxin-binding
Could be important to modulate the pK values of the two catalytic cysteine residues
DNA topoisomerase I catalytic core eukaryotic-type
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Peptidase M1 membrane alanine aminopeptidase
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Superoxide dismutase copper/zinc binding
S-adenosyl-L-homocysteine hydrolase NAD binding
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Anthranilate synthase component I N-terminal
Large ribosomal subunit protein uL15/eL18
Protein O-mannosyl-transferase C-terminal four TM
Glucose/Sorbosone dehydrogenase domain-containing protein
Septum formation-related domain-containing protein
Cytochrome b/b6 N-terminal region profile
Cell envelope-related transcriptional attenuator
Phosphomannose isomerase type I catalytic
Exported alanine and valine rich protein
4'-phosphopantetheinyl transferase N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Na+/H+ antiporter MnhB subunit-related protein
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Arabinofuranosyltransferase AftA C-terminal
Arabinofuranosyltransferase AftA N-terminal
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Solute-binding protein family 5 domain-containing protein
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Myo-inositol-1-phosphate synthase GAPDH-like
ABC-type glycine betaine transport system substrate-binding
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-113)
Cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Large ribosomal subunit protein uL30-like ferredoxin-like fold
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Glycosyl transferase family 3 N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
YbaK/aminoacyl-tRNA synthetase-associated
Peptide methionine sulphoxide reductase MsrA
Pyridine nucleotide-disulfide oxidoreductase
Thymidylate synthase/dCMP hydroxymethylase
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Cysteine sulfenic acid (-SOH) intermediate
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Phosphoribosylformylglycinamidine synthase linker
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Ribosomal RNA adenine methylase transferase N-terminal
ESX-1 secretion-associated protein EspA/EspE-like
Plays an important role in substrate specificity
RNA 2-O ribose methyltransferase substrate binding
Cation-transporting P-type ATPase C-terminal
Shikimate dehydrogenase substrate binding N-terminal
Haemophore haem-binding domain-containing protein
Glycosyl transferase family 28 C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Phosphocysteine intermediate; for EIIB activity
Glutathionylspermidine synthase pre-ATP-grasp-like
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
2-isopropylmalate synthase LeuA allosteric (dimerisation)
Alanyl-transfer RNA synthetases family profile
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
6-phosphogluconate dehydrogenase C-terminal
Release factor glutamine methyltransferase N-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Gly-cisPro motif, important for rejection of L-amino acids
Adaptive response protein AidB N-terminal
Polysaccharide chain length determinant N-terminal
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Alpha galactosidase C-terminal beta sandwich
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Interaction with polymerase core subunit RpoC
Heat-inducible transcription repressor HrcA C-terminal
Exonuclease VII large subunit C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Important for beta-aspartyl-AMP intermediate formation
Pyrroline-5-carboxylate reductase dimerisation
NADH:ubiquinone oxidoreductase 30kDa subunit
Resuscitation-promoting factor core lysozyme-like
Transcription regulator AsnC/Lrp ligand binding
Transposase IS116/IS110/IS902 C-terminal
Cytochrome C biogenesis protein transmembrane
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Alanine and proline-rich secreted protein Apa
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
C4-dicarboxylate ABC transporter substrate-binding protein
3-beta hydroxysteroid dehydrogenase/isomerase
Acyltransferase MbtK/IucB-like conserved
Glycosyltransferase family 28 N-terminal