Major facilitator superfamily (MFS) profile
Aminoacyl-transfer RNA synthetases class-II family profile
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
CobB/CobQ-like glutamine amidotransferase
Alkaline proteinase inhibitor/ Outer membrane lipoprotein Omp19 domain-containing protein
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Peptide methionine sulphoxide reductase MsrA
Type II secretion system protein GspI C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Polysaccharide chain length determinant N-terminal
TonB-dependent receptor plug domain-containing protein
tRNA pseudouridylate synthase B C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
General stress protein FMN-binding split barrel
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Protein O-mannosyl-transferase C-terminal four TM
TonB-dependent receptor-like beta-barrel
Prokaryotic-type class I peptide chain release factors
Electron transfer flavoprotein alpha/beta-subunit N-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Organic solvent tolerance-like N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Beta-lactamase hydrolase-like protein phosphatase-like
Moybdenum cofactor oxidoreductase dimerisation
Pyruvate phosphate dikinase AMP/ATP-binding
N-end rule aminoacyl transferase C-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Phosphoribosylformylglycinamidine synthase linker
Flagellar basal body rod protein N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Tryptophan synthase beta chain-like PALP
Right handed beta helix domain-containing protein
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Interaction with polymerase core subunit RpoC
Thymidylate synthase/dCMP hydroxymethylase
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
Peptidase M1 membrane alanine aminopeptidase
Exonuclease VII large subunit C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Aconitase A/isopropylmalate dehydratase small subunit swivel
Alpha-D-phosphohexomutase alpha/beta/alpha
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
NIF system FeS cluster assembly NifU N-terminal
DNA-directed DNA polymerase family A palm
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Polysaccharide biosynthesis protein C-terminal
S-adenosylmethionine-dependent methyltransferase
Pyridoxamine 5'-phosphate oxidase putative
Histidine phosphotransferase ChpT C-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
RNA binding; important for wobble base 34 recognition
Signal transduction histidine kinase HWE region
Type II secretion system protein GspC N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Schiff-base intermediate with dihydroxyacetone-P
Helix-hairpin-helix DNA-binding motif class 1
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-100)
Phosphoadenosine phosphosulphate reductase
Nucleophile; cysteine thiosulfonate intermediate
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Heme-copper oxidase subunit III family profile
Ribose-phosphate pyrophosphokinase N-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
O-(5'-phospho-DNA)-tyrosine intermediate
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Flagellar basal-body/hook protein C-terminal
Glycosyltransferase subfamily 4-like N-terminal
Increases nucleophilicity of active site Cys
ABC-type transport auxiliary lipoprotein component
Cytochrome b561 bacterial/Ni-hydrogenase
SUF system FeS cluster assembly SufBD N-terminal
Membrane fusion protein biotin-lipoyl like
Biopterin-dependent aromatic amino acid hydroxylase family profile
TtsA-like Glycoside hydrolase family 108
Release factor glutamine methyltransferase N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Large ribosomal subunit protein uL6 alpha-beta
Large ribosomal subunit protein uL2 C-terminal
Outer membrane protein assembly factor BamD
C-type lysozyme inhibitor domain-containing protein
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Activator of Hsp90 ATPase homologue 1-like C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glycosyl transferase family 3 N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Important for beta-aspartyl-AMP intermediate formation
Could play a key role in the communication between the regulatory and the substrate sites
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Plays an important role in substrate specificity
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Prepilin type IV endopeptidase peptidase
Resolvase/invertase-type recombinase catalytic
NAD(P) transhydrogenase alpha subunit C-terminal
DNA mismatch repair proteins mutS family
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Sodium/calcium exchanger membrane region
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Flagella basal body P-ring formation protein FlgA C-terminal
Polymerase/histidinol phosphatase N-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Flagellar motor switch protein FliN-like C-terminal
Restriction endonuclease type II DpnII-like
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Carbamoyl-phosphate synthetase large subunit-like ATP-binding
YMGG-like Gly-zipper domain-containing protein
S-adenosyl-L-homocysteine hydrolase NAD binding
Anthranilate synthase component I N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Chromosomal replication initiator DnaA C-terminal
Type 2A encapsulin shell protein SrpI-like
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Quercetin 2,3-dioxygenase C-terminal cupin
Required for zinc-mediated homotetramerization and catalytic activity
Signal transduction histidine kinase internal region
Large ribosomal subunit protein uL15/eL18
Pseudouridine synthase I TruA alpha/beta
Secretin/TonB short N-terminal domain-containing protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Heavy-metal-associated domain-containing protein
Putative auto-transporter adhesin head GIN
Putative auto-transporter adhesin head GIN domain-containing protein
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Mandelate racemase/muconate lactonizing enzyme C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Flagellar hook-length control protein-like C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Outer membrane protein assembly factor BamA
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Alanyl-transfer RNA synthetases family profile
Terminase large subunit gp17-like C-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
PHA accumulation regulator DNA-binding N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
6-phosphogluconate dehydrogenase C-terminal
Alpha-L-rhamnosidase six-hairpin glycosidase
D-galactarate/Altronate dehydratase C-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Hydroquinone 1,2-dioxygenase large subunit N-terminal
O-(phosphoribosyl dephospho-coenzyme A)serine
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Cobaltochelatase subunit CobS N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Electron transfer via tryptophanyl radical
Proton acceptor; for glutaminase activity
Penicillin-binding protein transpeptidase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Signal recognition particle SRP54 helical bundle
Shikimate dehydrogenase substrate binding N-terminal
RNA 2-O ribose methyltransferase substrate binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Glycosyl hydrolases family 2 sugar binding domain-containing protein
O-(3'-phospho-DNA)-tyrosine intermediate
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Flagellar assembly protein FliH/Type III secretion system HrpE
Thiol:disulfide interchange protein DsbD N-terminal
Histidine-specific methyltransferase SAM-dependent
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Peptide methionine sulfoxide reductase MsrA
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Small ribosomal subunit protein uS4 N-terminal
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
Reversibly protonated during proton transport
Spore coat protein U domain-containing protein
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Methionyl-tRNA synthetase anticodon-binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
DNA replication/recombination mediator RecO N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Sigma 54 modulation/S30EA ribosomal protein C-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Malonate/sodium symporter MadM subunit N-terminal
Beta-hexosaminidase bacterial type N-terminal
Poly-beta-hydroxybutyrate polymerase N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
DNA topoisomerase I catalytic core eukaryotic-type
Thioredoxin-like fold domain-containing protein
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
PhoD-like phosphatase metallophosphatase
Translation elongation factor P/YeiP central
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Tetrahydrodipicolinate-N-succinyltransferase chain A
Myo-inositol-1-phosphate synthase GAPDH-like
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Charge relay system; for autoendoproteolytic cleavage activity
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Superoxide dismutase copper/zinc binding
Nitrite/Sulfite reductase ferredoxin-like
Dienelactone hydrolase domain-containing protein
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Calcium-dependent phosphoinositide phospholipase C
Membrane insertase YidC/Oxa/ALB C-terminal
5-glutamyl coenzyme A thioester intermediate
Signal transduction histidine kinase subgroup 2 dimerisation and phosphoacceptor
Ribosomal RNA adenine methylase transferase N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Essential for prephenate dehydratase activity
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Alpha-glycerophosphate oxidase C-terminal
Alginate export domain-containing protein
Probable periplasmic serine endoprotease DegP-like
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
HicB-like antitoxin of toxin-antitoxin system
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Type III restriction enzyme C-terminal endonuclease
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal