Antitoxin Xre/MbcA/ParS-like toxin-binding
Plays an important role in substrate specificity
SUF system FeS cluster assembly SufBD N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Tryptophan synthase beta chain-like PALP
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Heat-inducible transcription repressor HrcA C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
ABC transporter substrate-binding protein PnrA-like
ATP synthase F1 complex delta/epsilon subunit N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Required for zinc-mediated homotetramerization and catalytic activity
Penicillin-binding protein transpeptidase
Major facilitator superfamily (MFS) profile
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Lysozyme inhibitor LprI N-terminal domain-containing protein
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Important for beta-aspartyl-AMP intermediate formation
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS domain-containing protein
Solute-binding protein family 3/N-terminal
Solute-binding protein family 3/N-terminal domain-containing protein
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Glucose-methanol-choline oxidoreductase N-terminal
Chromosomal replication initiator DnaA C-terminal
Alpha-glycerophosphate oxidase C-terminal
TonB-dependent receptor plug domain-containing protein
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Glycosyl transferase family 3 N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Probable transposase IS891/IS1136/IS1341
Organic solvent tolerance-like N-terminal
Organic solvent tolerance-like N-terminal domain-containing protein
DNA-directed DNA polymerase family A palm
Large ribosomal subunit protein uL6 alpha-beta
Resolvase/invertase-type recombinase catalytic
Thymidylate synthase/dCMP hydroxymethylase
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
O-(3'-phospho-DNA)-tyrosine intermediate
Gp5/Type VI secretion system Vgr protein OB-fold
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
NAD(P) transhydrogenase alpha subunit C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Large ribosomal subunit protein uL2 C-terminal
Survival protein SurE-like phosphatase/nucleotidase
Alpha-D-phosphohexomutase alpha/beta/alpha
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Inner membrane protein YgaP-like transmembrane
Urease accessory protein UreH-like transmembrane
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Phosphoribosylformylglycinamidine synthase linker
RND efflux pump membrane fusion protein barrel-sandwich
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
TonB-dependent receptor-like beta-barrel
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
DNA mismatch repair proteins mutS family
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Mannose-6-phosphate isomerase type II C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Cytochrome b561 bacterial/Ni-hydrogenase
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Invasion associated locus B family protein
Interacts with tRNA; defines subfamily-specific binding signature
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Sugar fermentation stimulation protein C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Flagellar hook-length control protein-like C-terminal
Electron transfer via tryptophanyl radical
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Important for interaction with partner proteins
UDP N-acetylglucosamine O-acyltransferase C-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Could be important to modulate the pK values of the two catalytic cysteine residues
Carbamoyl-phosphate synthase small subunit N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Glycoside-hydrolase family GH114 TIM-barrel domain-containing protein
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
RNA 2-O ribose methyltransferase substrate binding
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Alanyl-transfer RNA synthetases family profile
Flagellar assembly protein FliH/Type III secretion system HrpE
Chromosomal replication initiator protein DnaA
Acetyl-CoA dehydrogenase-like C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
tRNA pseudouridylate synthase B C-terminal
Reversibly protonated during proton transport
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glucosamine/galactosamine-6-phosphate isomerase
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Phosphatidic acid phosphatase type 2/haloperoxidase
ABC transporter substrate-binding protein
Poly-beta-hydroxybutyrate polymerase N-terminal
DNA replication/recombination mediator RecO N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Release factor glutamine methyltransferase N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Prokaryotic-type class I peptide chain release factors
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Interaction with polymerase core subunit RpoC
Anthranilate synthase component I N-terminal
Membrane fusion protein biotin-lipoyl like
Terminase large subunit gp17-like C-terminal
Exonuclease VII large subunit C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Proton acceptor; for glutaminase activity
Flagellar motor switch protein FliN-like C-terminal
Plasmid replication protein C N-terminal
Major facilitator superfamily associated
Leucine-binding protein domain-containing protein
Transcription factor LuxR-like autoinducer-binding
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Transglycosylase SLT domain-containing protein
6-hydroxymethylpterin diphosphokinase MptE-like
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
ABC-type glycine betaine transport system substrate-binding
ABC-type glycine betaine transport system substrate-binding domain-containing protein
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Autotransporter domain-containing protein
RNA binding; important for wobble base 34 recognition
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Type II restriction enzyme and methyltransferase RM.Eco57I-like
Pyruvate/ketoisovalerate oxidoreductase catalytic
Thiamine pyrophosphate enzyme TPP-binding
Polymerase/histidinol phosphatase N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Solute-binding protein family 5 domain-containing protein
TtsA-like Glycoside hydrolase family 108
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Aromatic hydrocarbon degradation protein
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Polysaccharide biosynthesis protein CapD-like
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Ionotropic glutamate receptor C-terminal
Small ribosomal subunit protein uS4 N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Beta-1-3, beta-1-6-glucan biosynthesis protein
NADH:ubiquinone oxidoreductase 30kDa subunit
Blue (type 1) copper domain-containing protein
Glycosyltransferase 2-like domain-containing protein
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Pseudouridine synthase I TruA alpha/beta
Large ribosomal subunit protein uL15/eL18
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
ABC-type transport auxiliary lipoprotein component domain-containing protein
High-affinity zinc uptake system protein ZnuA
PHA accumulation regulator DNA-binding N-terminal
Bacteriophage N4 adsorption protein A C-terminal
Transcription regulator AsnC/Lrp ligand binding
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
N-end rule aminoacyl transferase C-terminal
Methionyl-tRNA synthetase anticodon-binding
Phage terminase large subunit GpA ATPase
Terminase large subunit GpA endonuclease
HicB-like antitoxin of toxin-antitoxin system
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Phosphotransferase system enzyme I N-terminal
Heme-copper oxidase subunit III family profile
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
YbaK/aminoacyl-tRNA synthetase-associated
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Probable periplasmic serine endoprotease DegP-like
Acyl-CoA dehydrogenase N-terminal bacteria
Histidine phosphotransferase ChpT C-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Important for substrate specificity; cannot use PPi as phosphoryl donor
Sulfatase-modifying factor enzyme domain-containing protein
Translation elongation factor P/YeiP central
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Pyruvate phosphate dikinase AMP/ATP-binding
Membrane insertase YidC/Oxa/ALB C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Aminoacyl-tRNA synthetase class I anticodon-binding
Saccharopine dehydrogenase-like C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
NADH:ubiquinone oxidoreductase chain 4 N-terminal