Interacts with tRNA; defines subfamily-specific binding signature
Pyrimidine nucleoside phosphorylase C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
6-phosphogluconate dehydrogenase NADP-binding
Phosphogluconate dehydrogenase (decarboxylating) C-terminal
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Polysaccharide chain length determinant N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Polypeptide-transport-associated ShlB-type
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
DNA-directed DNA polymerase family A palm
Major facilitator superfamily (MFS) profile
Pseudouridine synthase I TruA alpha/beta
Transposase IS116/IS110/IS902 C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Solute-binding protein family 3/N-terminal
Major facilitator superfamily associated
Endoribonuclease L-PSP/chorismate mutase-like
ATP synthase F1 complex delta/epsilon subunit N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
Alanyl-transfer RNA synthetases family profile
Flagella basal body P-ring formation protein FlgA
Flagella basal body P-ring formation protein FlgA C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Mandelate racemase/muconate lactonizing enzyme C-terminal
Nitrite/Sulfite reductase ferredoxin-like
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
ABC transporter substrate-binding protein
Probable periplasmic serine endoprotease DegP-like
Cytochrome b561 bacterial/Ni-hydrogenase
Glucosamine/galactosamine-6-phosphate isomerase
Flagellar motor switch protein FliN-like C-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
O-(5'-phospho-DNA)-tyrosine intermediate
Penicillin-binding protein transpeptidase
Glycosyltransferase subfamily 4-like N-terminal
Leucine-binding protein domain-containing protein
Membrane fusion protein biotin-lipoyl like
RND efflux pump membrane fusion protein barrel-sandwich
YbaK/aminoacyl-tRNA synthetase-associated
Interaction with polymerase core subunit RpoC
O-(3'-phospho-DNA)-tyrosine intermediate
Tryptophan synthase beta chain-like PALP
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Glutathionylspermidine synthase pre-ATP-grasp-like
RNA binding; important for wobble base 34 recognition
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Lysozyme inhibitor LprI N-terminal domain-containing protein
Right handed beta helix domain-containing protein
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Glucose-methanol-choline oxidoreductase N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
HicB-like antitoxin of toxin-antitoxin system
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Transcriptional regulator LacI/GalR-like sensor
Release factor glutamine methyltransferase N-terminal
SUF system FeS cluster assembly SufBD N-terminal
C-type lysozyme inhibitor domain-containing protein
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Tetrahydrodipicolinate-N-succinyltransferase chain A
DNA topoisomerase I catalytic core eukaryotic-type
Polysaccharide biosynthesis protein CapD-like
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glycosyl transferase family 28 C-terminal
Transcription regulator AsnC/Lrp ligand binding
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Could be important to modulate the pK values of the two catalytic cysteine residues
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
5-glutamyl coenzyme A thioester intermediate
Sodium/calcium exchanger membrane region
Pyruvate phosphate dikinase AMP/ATP-binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Polysaccharide biosynthesis protein C-terminal
NADH-rubredoxin oxidoreductase C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-95)
Mannose-6-phosphate isomerase type II C-terminal
Outer membrane protein assembly factor BamA
Pyruvate/ketoisovalerate oxidoreductase catalytic
Proton acceptor; for glutaminase activity
Phosphate starvation-inducible protein PsiF
TonB-dependent receptor-like beta-barrel
Aminoacyl-transfer RNA synthetases class-II family profile
Alpha-glycerophosphate oxidase C-terminal
Tripartite tricarboxylate transporter substrate binding protein
L,D-transpeptidase catalytic domain-containing protein
Electron transfer via tryptophanyl radical
Invasion associated locus B family protein
AB hydrolase-1 domain-containing protein
Glucose-methanol-choline oxidoreductase C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Peptide methionine sulphoxide reductase MsrA
Activator of Hsp90 ATPase homologue 1-like C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Glycine zipper domain-containing protein
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Flagellar hook-length control protein-like C-terminal
Autotransporter domain-containing protein
Metallo-beta-lactamase domain-containing protein
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Phosphoadenosine phosphosulphate reductase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
SsuA/THI5-like domain-containing protein
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Outer membrane protein beta-barrel domain-containing protein
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Phenol hydroxylase C-terminal dimerisation
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Cytochrome c oxidase subunit IV bacterial aa3 type
Important for interaction with partner proteins
Gp5/Type VI secretion system Vgr protein OB-fold
Bacterial bifunctional deaminase-reductase C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
RND efflux pump membrane fusion protein barrel-sandwich domain-containing protein
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
FAD-dependent oxidoreductase 2 FAD binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Large ribosomal subunit protein uL15/eL18
DNA replication/recombination mediator RecO N-terminal
Prepilin type IV endopeptidase peptidase
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Acetylserotonin O-methyltransferase dimerisation
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Large ribosomal subunit protein uL2 C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Solute-binding protein family 5 domain-containing protein
ABC-type glycine betaine transport system substrate-binding
Saccharopine dehydrogenase-like C-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Aconitase A/isopropylmalate dehydratase small subunit swivel
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Required for zinc-mediated homotetramerization and catalytic activity
D-galactarate/Altronate dehydratase C-terminal
Mandelate racemase/muconate lactonizing enzyme N-terminal
Type VI secretion system IcmF C-terminal
Heme-copper oxidase subunit III family profile
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Intradiol ring-cleavage dioxygenases domain-containing protein
Ribosomal RNA adenine methylase transferase N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Anthranilate synthase component I N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Essential for prephenate dehydratase activity
AsmA-like C-terminal domain-containing protein
UDP N-acetylglucosamine O-acyltransferase C-terminal
Thymidylate synthase/dCMP hydroxymethylase
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Glycine cleavage T-protein C-terminal barrel
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Glycosyltransferase family 28 N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Histidine phosphotransferase ChpT C-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Aldehyde oxidase/xanthine dehydrogenase second molybdopterin binding
Large ribosomal subunit protein uL6 alpha-beta
Cobaltochelatase subunit CobS N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Tetratricopeptide repeat-like domain-containing protein
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Involved in tetramerization or stability of the tetramer
Fibronectin type III-like domain-containing protein
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Glycosyl transferase family 3 N-terminal
Autotransporter secretion inner membrane protein TamB
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Solute-binding protein family 3/N-terminal domain-containing protein
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Cob(I)alamin adenosyltransferase N-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Resolvase/invertase-type recombinase catalytic
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Phosphoribosylformylglycinamidine synthase linker
Molybdate ABC transporter substrate-binding protein
Antitoxin Xre/MbcA/ParS-like toxin-binding
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal domain-containing protein
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Signal transduction histidine kinase HWE region
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
General stress protein FMN-binding split barrel
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Phosphotransferase system enzyme I N-terminal
Caspase family p20 domain-containing protein
Ribose-phosphate pyrophosphokinase N-terminal
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
N-end rule aminoacyl transferase C-terminal
Plasmid replication protein C C-terminal
Plasmid replication protein C N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
NIF system FeS cluster assembly NifU N-terminal
Plays an important role in substrate specificity
CagE TrbE VirB component of type IV transporter system central
Translation elongation factor P/YeiP central
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Glucan biosynthesis periplasmic MdoG C-terminal
Involved in allosteric activation by GTP
Phosphatidic acid phosphatase type 2/haloperoxidase
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
TtsA-like Glycoside hydrolase family 108
Poly A polymerase head domain-containing protein
Transglycosylase SLT domain-containing protein
Bacterial type II secretion system protein E
Exonuclease VII large subunit C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Glutamate synthase alpha subunit C-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
Septum formation inhibitor MinC C-terminal
Dienelactone hydrolase domain-containing protein
Ionotropic glutamate receptor C-terminal
DNA mismatch repair proteins mutS family
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Prokaryotic-type class I peptide chain release factors
Cysteine sulfenic acid (-SOH) intermediate
Aromatic hydrocarbon degradation protein
Poly-beta-hydroxybutyrate polymerase N-terminal
Pili assembly chaperone N-terminal domain-containing protein
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Glucose/Sorbosone dehydrogenase domain-containing protein
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Gamma-butyrobetaine hydroxylase-like N-terminal
N,N-dimethylformamidase beta subunit-like C-terminal
Agrobacterium tumefaciens protein Atu4866
Acyltransferase MbtK/IucB-like conserved
PHA accumulation regulator DNA-binding N-terminal
Methionyl-tRNA synthetase anticodon-binding
Trimeric autotransporter adhesin YadA-like C-terminal membrane anchor
Trimeric autotransporter adhesin YadA-like head
Trimeric autotransporter adhesin YadA-like stalk
NAD(P) transhydrogenase alpha subunit C-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Polymerase/histidinol phosphatase N-terminal
Peptidase M14 carboxypeptidase A domain-containing protein
Aspartate/homoserine dehydrogenase NAD-binding
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Glyoxalase/fosfomycin resistance/dioxygenase
Small ribosomal subunit protein uS4 N-terminal
Moybdenum cofactor oxidoreductase dimerisation
Reversibly protonated during proton transport
NADH:ubiquinone oxidoreductase 30kDa subunit
SGNH hydrolase-type esterase domain-containing protein
Flavocytochrome c sulphide dehydrogenase flavin-binding
6-phosphogluconate dehydrogenase C-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Signal transduction histidine kinase subgroup 2 dimerisation and phosphoacceptor
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Pyrroline-5-carboxylate reductase dimerisation
Glycoside hydrolase family 31 N-terminal
Ca-activated chloride channel family protein
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
ABC transporter substrate-binding protein PnrA-like
Lipoprotein SmpA/OmlA domain-containing protein
CDP-alcohol phosphatidyltransferase C-terminal
Peptidase M15A C-terminal domain-containing protein