Aminoacyl-transfer RNA synthetases class-II family profile
Gly-cisPro motif, important for rejection of L-amino acids
O-(5'-phospho-DNA)-tyrosine intermediate
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Putative host cell surface-exposed lipoprotein Ltp-like HTH region
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Phosphocysteine intermediate; for EIIB activity
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
SbsC C-terminal domain-containing protein
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Bacterial Ig-like domain-containing protein
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Penicillin-binding protein transpeptidase
Serine-type D-Ala-D-Ala carboxypeptidase
RNA polymerase sigma factor 70 region 4 type 2
Phosphoinositide-specific phospholipase C EF-hand-like
Probable transposase IS891/IS1136/IS1341
Bacterial type II secretion system protein E
Glycosyl transferase family 3 N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
DnaJ homologue subfamily C member 28 conserved
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Polysaccharide biosynthesis protein CapD-like
Aspartate/homoserine dehydrogenase NAD-binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Could be important to modulate the pK values of the two catalytic cysteine residues
Gram-positive cocci surface proteins LPxTG
Gram-positive cocci surface proteins LPxTG domain-containing protein
Urease accessory protein UreH-like transmembrane
Pseudouridine synthase I TruA alpha/beta
Thymidylate synthase/dCMP hydroxymethylase
Type I restriction modification DNA specificity
Polysaccharide chain length determinant N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Major facilitator superfamily (MFS) profile
Cell wall-active antibiotics response LiaF-like C-terminal
Sporulation initiation phosphotransferase B C-terminal
Terminase large subunit-like endonuclease
DNA polymerase III delta subunit C-terminal
Tryptophan synthase beta chain-like PALP
Resolvase/invertase-type recombinase catalytic
Peptidase S9 prolyl oligopeptidase catalytic
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
Na+/H+ antiporter MnhB subunit-related protein
Bacterial transcription activator effector binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Helix-hairpin-helix DNA-binding motif class 1
Polymerase/histidinol phosphatase N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Na+-translocating membrane potential-generating system MpsC
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Peptidase S8/S53 domain-containing protein
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Ribosomal RNA adenine methylase transferase N-terminal
Polysaccharide biosynthesis protein C-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-110)
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Transglutaminase-like domain-containing protein
ATP synthase F1 complex delta/epsilon subunit N-terminal
Electron transfer via tryptophanyl radical
TRAP C4-dicarboxylate transport system permease DctM subunit
Nitrite/Sulfite reductase ferredoxin-like
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Nicotinamide phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Peptidase M6-like domain-containing protein
Glycosyltransferase subfamily 4-like N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
SUF system FeS cluster assembly SufBD N-terminal
Alanyl-transfer RNA synthetases family profile
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Prepilin type IV endopeptidase peptidase
Tellurite resistance methyltransferase TehB-like
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Cytochrome b/b6 C-terminal region profile
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Cytochrome b/b6 N-terminal region profile
Non-canonical purine NTP phosphatase/PRRC1
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
Sodium symporter small subunit predicted
Microcin J25-processing protein McjB C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Glyoxalase/fosfomycin resistance/dioxygenase
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Phosphatidic acid phosphatase type 2/haloperoxidase
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Anthranilate synthase component I N-terminal
Thiamin/hydroxymethyl pyrimidine-binding YkoF putative
DNA-directed RNA polymerase RpoA/D/Rpb3-type
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Acyl-CoA dehydrogenase/oxidase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Small ribosomal subunit protein uS4 N-terminal
Capsule synthesis protein CapA domain-containing protein
Important for interaction with partner proteins
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Aconitase A/isopropylmalate dehydratase small subunit swivel
DNA replication/recombination mediator RecO N-terminal
Peptide methionine sulphoxide reductase MsrA
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Glycine cleavage T-protein C-terminal barrel
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Prokaryotic-type class I peptide chain release factors
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Flagellar motor switch protein FliN-like C-terminal
Major facilitator superfamily associated
Formamidopyrimidine-DNA glycosylase catalytic
Pyruvate ferredoxin oxidoreductase beta subunit C-terminal
Thiamine pyrophosphate enzyme TPP-binding
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Large ribosomal subunit protein uL2 C-terminal
Alpha-glycerophosphate oxidase C-terminal
Gamma-glutamylcyclotransferase AIG2-like
tRNA pseudouridylate synthase B C-terminal
S-adenosylmethionine-dependent methyltransferase
Phosphotransferase system enzyme I N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Thiamin pyrophosphokinase thiamin-binding
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Glucosamine/galactosamine-6-phosphate isomerase
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Sodium/calcium exchanger membrane region
Lactate utilization protein B C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
YbaK/aminoacyl-tRNA synthetase-associated
Carbamoyl-phosphate synthase small subunit N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Involved in allosteric activation by GTP
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Phosphoribosylformylglycinamidine synthase linker
Exonuclease VII large subunit C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
6-hydroxymethylpterin diphosphokinase MptE-like
Spore germination GerAC-like C-terminal domain-containing protein
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Fe/B12 periplasmic-binding domain-containing protein
Schiff-base intermediate with D-ribose 5-phosphate
Intracellular proteinase inhibitor BsuPI
Cell envelope-related transcriptional attenuator
Endonuclease/exonuclease/phosphatase domain-containing protein
Ribose-phosphate pyrophosphokinase N-terminal
RNA 2-O ribose methyltransferase substrate binding
HicB-like antitoxin of toxin-antitoxin system
Essential for prephenate dehydratase activity
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Putative Flp pilus-assembly TadG-like N-terminal
Menaquinone biosynthesis protein MenD middle
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Heme-copper oxidase subunit III family profile
Putative aromatic acid exporter C-terminal
May play a role in transmitting local conformational changes
ABC transporter substrate-binding protein
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Tryptophan RNA-binding attenuator protein
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
NIF system FeS cluster assembly NifU N-terminal
General stress protein FMN-binding split barrel
RNA binding; important for wobble base 34 recognition
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Elongation factor G-binding protein N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Plays an important role in substrate specificity
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Sporulation transcription regulator WhiA N-terminal
Magnesium transporter MgtE intracellular
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
6-phosphogluconate dehydrogenase C-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Interaction with polymerase core subunit RpoC
ABC transporter substrate-binding protein PnrA-like
Solute-binding protein family 3/N-terminal domain-containing protein
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Glycosyl hydrolase family 13 catalytic domain-containing protein
SMODS-associated and fused to various effectors
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Single-stranded-DNA-specific exonuclease RecJ C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Bypass-of-forespore C N-terminal domain-containing protein
Copper amine oxidase-like N-terminal domain-containing protein
Large ribosomal subunit protein uL15/eL18
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
RDXXRA motif of the pArg binding pocket involved in allosteric regulation
Global transcriptional regulator CodY C-terminal
Global transcriptional regulator CodY N-terminal
Heat-inducible transcription repressor HrcA C-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Right handed beta helix domain-containing protein
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Phage conserved hypothetical protein C-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Flagellar hook-length control protein-like C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Cytochrome C biogenesis protein transmembrane
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Type III secretion system flagellar brake protein YcgR PilZN
Chromosomal replication initiator DnaA C-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Positions MEP for the nucleophilic attack
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Schiff-base intermediate with dihydroxyacetone-P
Translation elongation factor P/YeiP central
ABC transporter periplasmic binding protein yphF
Glutathionylspermidine synthase pre-ATP-grasp-like
Important for beta-aspartyl-AMP intermediate formation
Conserved virulence factor B-like winged helix