Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Prokaryotic-type class I peptide chain release factors
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
NADH:flavin oxidoreductase/NADH oxidase N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Gamma-butyrobetaine hydroxylase-like N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
NADH:ubiquinone oxidoreductase 30kDa subunit
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Tripartite tricarboxylate transporter substrate binding protein
Required for dimer formation and molybdate binding
TRAP C4-dicarboxylate transport system permease DctM subunit
Peptidase S9 prolyl oligopeptidase catalytic
Major facilitator superfamily (MFS) profile
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Sodium/calcium exchanger membrane region
Choloylglycine hydrolase/NAAA C-terminal
Inosine/uridine-preferring nucleoside hydrolase
O-(5'-phospho-DNA)-tyrosine intermediate
Aminoacyl-transfer RNA synthetases class-II family profile
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Dinitrogenase iron-molybdenum cofactor N-terminal
Dinitrogenase iron-molybdenum cofactor biosynthesis
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Important for interaction with partner proteins
Glycosyltransferase subfamily 4-like N-terminal
Release factor glutamine methyltransferase N-terminal
5-glutamyl coenzyme A thioester intermediate
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
ABC-type glycine betaine transport system substrate-binding
Cation-transporting P-type ATPase N-terminal
Histidine phosphotransferase ChpT C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Plays an important role in substrate specificity
TonB-dependent receptor-like beta-barrel
Aconitase A/isopropylmalate dehydratase small subunit swivel
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Ribosomal RNA adenine methylase transferase N-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
RNA polymerase sigma factor 70 region 4 type 2
RND efflux pump membrane fusion protein barrel-sandwich domain-containing protein
L,D-transpeptidase catalytic domain-containing protein
Saccharopine dehydrogenase-like C-terminal
Nitrogenase molybdenum-iron protein beta chain N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Anthranilate synthase component I N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Outer membrane protein beta-barrel domain-containing protein
6-phosphogluconate dehydrogenase C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Polypeptide-transport-associated ShlB-type
Polysaccharide chain length determinant N-terminal
Glycine cleavage T-protein C-terminal barrel
Solute-binding protein family 3/N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
SUF system FeS cluster assembly SufBD N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Mandelate racemase/muconate lactonizing enzyme C-terminal
Exonuclease VII large subunit C-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Cytochrome c-type biogenesis protein CcmF C-terminal
Beta-lactamase-related domain-containing protein
Quercetin 2,3-dioxygenase C-terminal cupin
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Glycoside hydrolase family 31 N-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Transferrin-binding protein B C-lobe/N-lobe beta barrel domain-containing protein
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Glycosyl transferase family 28 C-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
ABC transporter substrate-binding protein
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Glucan biosynthesis periplasmic MdoG C-terminal
C-type lysozyme inhibitor domain-containing protein
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
DNA replication/recombination mediator RecO N-terminal
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Survival protein SurE-like phosphatase/nucleotidase
N-sulphoglucosamine sulphohydrolase C-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Beta-lactamase hydrolase-like protein phosphatase-like
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Alpha-D-phosphohexomutase alpha/beta/alpha
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Cysteine sulfenic acid (-SOH) intermediate
Tat pathway signal sequence domain protein
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Membrane insertase YidC/Oxa/ALB C-terminal
Heme-copper oxidase subunit III family profile
Could be important to modulate the pK values of the two catalytic cysteine residues
Pyruvate phosphate dikinase AMP/ATP-binding
Solute-binding protein family 3/N-terminal domain-containing protein
Neutral/alkaline non-lysosomal ceramidase N-terminal
von Hippel-Lindau disease tumour suppressor beta
von Hippel-Lindau disease tumour suppressor beta domain-containing protein
Signal transduction histidine kinase HWE region
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
NIF system FeS cluster assembly NifU N-terminal
Glycosyl hydrolases family 2 sugar binding
Adaptive response protein AidB N-terminal
Thiamin/hydroxymethyl pyrimidine-binding YkoF putative
Pyrroline-5-carboxylate reductase catalytic N-terminal
Penicillin-binding protein transpeptidase
Nitrite/Sulfite reductase ferredoxin-like
PHA accumulation regulator DNA-binding N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Cytochrome c oxidase subunit IV bacterial aa3 type
Ionotropic glutamate receptor C-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
C4-dicarboxylate ABC transporter substrate-binding protein
Na+/H+ antiporter MnhB subunit-related protein
Essential for prephenate dehydratase activity
Transposase IS116/IS110/IS902 C-terminal
Interaction with polymerase core subunit RpoC
Thymidylate synthase/dCMP hydroxymethylase
Glycosyl transferase family 3 N-terminal
Membrane fusion protein biotin-lipoyl like
ATP synthase F1 complex delta/epsilon subunit N-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Tryptophan synthase beta chain-like PALP
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Molybdopterin cofactor biosynthesis C (MoaC)
O-(3'-phospho-DNA)-tyrosine intermediate
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Alpha-glycerophosphate oxidase C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Twin-arginine translocation pathway signal
Surface antigen domain-containing protein
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Mannose-6-phosphate isomerase type II C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Required for zinc-mediated homotetramerization and catalytic activity
Glycoside hydrolase family 42 N-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Phosphoribosylformylglycinamidine synthase linker
Polymerase/histidinol phosphatase N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Solute-binding protein family 5 domain-containing protein
CDP-alcohol phosphatidyltransferase C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Cytochrome C biogenesis protein transmembrane
Glucosamine/galactosamine-6-phosphate isomerase
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
S-adenosyl-L-homocysteine hydrolase NAD binding
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Pyrimidine nucleoside phosphorylase C-terminal
Sugar ABC transporter substrate-binding protein
Phage terminase large subunit GpA ATPase
Terminase large subunit GpA endonuclease
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
RNA 2-O ribose methyltransferase substrate binding
Transcription regulator AsnC/Lrp ligand binding
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
RNA binding; important for wobble base 34 recognition
Glycosyltransferase family 28 N-terminal
Peptide methionine sulphoxide reductase MsrA
UDP N-acetylglucosamine O-acyltransferase C-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Probable periplasmic serine endoprotease DegP-like
DNA mismatch repair proteins mutS family
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Antitoxin Xre/MbcA/ParS-like toxin-binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
NADH-rubredoxin oxidoreductase C-terminal
Reversibly protonated during proton transport
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Proton acceptor; for glutaminase activity
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Sugar fermentation stimulation protein C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Autotransporter domain-containing protein
Outer membrane protein assembly factor BamA
Chromosomal replication initiator DnaA C-terminal
Thiamin pyrophosphokinase thiamin-binding
Cobaltochelatase subunit CobS N-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Inner membrane protein YgaP-like transmembrane
N-end rule aminoacyl transferase C-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Pseudouridine synthase I TruA alpha/beta
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
ABC transporter substrate-binding protein PnrA-like
SsuA/THI5-like domain-containing protein
Could play a key role in the communication between the regulatory and the substrate sites
Integral membrane protein YccS N-terminal
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
DNA-directed DNA polymerase family A palm
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Translation elongation factor P/YeiP central
Chromosomal replication initiator protein DnaA
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Alanyl-transfer RNA synthetases family profile
Glutamate synthase alpha subunit C-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Methionyl-tRNA synthetase anticodon-binding
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
2,4-diaminopentanoate dehydrogenase C-terminal
Signal transduction histidine kinase internal region
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Beta-hexosaminidase bacterial type N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Large ribosomal subunit protein uL15/eL18
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Heat-inducible transcription repressor HrcA C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Large ribosomal subunit protein uL2 C-terminal
Small ribosomal subunit protein uS4 N-terminal