D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Large ribosomal subunit protein uL6 alpha-beta
Transcriptional regulator AbiEi antitoxin N-terminal
ABC transporter substrate-binding protein PnrA-like
Glycine cleavage T-protein C-terminal barrel
Disulphide bond isomerase DsbC/G N-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Aminoacyl-transfer RNA synthetases class-II family profile
Interacts with tRNA; defines subfamily-specific binding signature
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Mannose-6-phosphate isomerase type II C-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Major facilitator superfamily (MFS) profile
Solute-binding protein family 3/N-terminal
Solute-binding protein family 3/N-terminal domain-containing protein
Bacterial bifunctional deaminase-reductase C-terminal
Outer membrane protein beta-barrel domain-containing protein
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Nitrite/Sulfite reductase ferredoxin-like
Small ribosomal subunit protein uS4 N-terminal
Interaction with polymerase core subunit RpoC
Large ribosomal subunit protein uL15/eL18
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Phenol hydroxylase C-terminal dimerisation
Beta-lactamase-related domain-containing protein
Exonuclease VII large subunit C-terminal
Reversibly protonated during proton transport
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
S-adenosylmethionine-dependent methyltransferase
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
RNA binding; important for wobble base 34 recognition
NADH:flavin oxidoreductase/NADH oxidase N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Na+/H+ antiporter MnhB subunit-related protein
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
ABC transporter substrate-binding protein
O-(5'-phospho-DNA)-tyrosine intermediate
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Outer membrane lipoprotein carrier protein LolA
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Toxin-antitoxin system YwqK family antitoxin
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Poly-beta-hydroxybutyrate polymerase N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
YbaK/aminoacyl-tRNA synthetase-associated
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Thymidylate synthase/dCMP hydroxymethylase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Proton acceptor; for glutaminase activity
Pyruvate dehydrogenase E1 component middle
RNA polymerase sigma factor 70 region 4 type 2
Chalcone isomerase domain-containing protein
Anthranilate synthase component I N-terminal
Large ribosomal subunit protein uL2 C-terminal
TonB-dependent receptor-like beta-barrel
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Prokaryotic-type class I peptide chain release factors
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Membrane fusion protein biotin-lipoyl like
Autotransporter domain-containing protein
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Essential for prephenate dehydratase activity
Positions MEP for the nucleophilic attack
Penicillin-binding protein transpeptidase
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Gamma-butyrobetaine hydroxylase-like N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Electron transfer flavoprotein alpha/beta-subunit N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Shikimate dehydrogenase substrate binding N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Phosphatidic acid phosphatase type 2/haloperoxidase
NIF system FeS cluster assembly NifU N-terminal
Ricin B lectin domain-containing protein
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Chromosomal replication initiator DnaA C-terminal
ABC-type glycine betaine transport system substrate-binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Mandelate racemase/muconate lactonizing enzyme C-terminal
Prepilin type IV endopeptidase peptidase
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Gp5/Type VI secretion system Vgr protein OB-fold
Membrane insertase YidC/Oxa/ALB C-terminal
Electron transfer via tryptophanyl radical
CobB/CobQ-like glutamine amidotransferase
Urease accessory protein UreH-like transmembrane
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Major facilitator superfamily associated
Phosphotransferase system enzyme I N-terminal
Penicillin-binding protein activator LpoB
Leucine-binding protein domain-containing protein
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Outer membrane protein assembly factor BamE
Outer-membrane lipoprotein carrier protein
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Tryptophan synthase beta chain-like PALP
Beta/gamma crystallin 'Greek key' domain-containing protein
Plays an important role in substrate specificity
Flagella basal body P-ring formation protein FlgA
Flagellar motor switch protein FliN-like C-terminal
Glycine zipper 2TM domain-containing protein
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Cytochrome b561 bacterial/Ni-hydrogenase
Activator of Hsp90 ATPase homologue 1-like C-terminal
Spore coat protein U domain-containing protein
DNA replication/recombination mediator RecO N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Peptidase S9 prolyl oligopeptidase catalytic
Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Outer membrane protein assembly factor BamB
Survival protein SurE-like phosphatase/nucleotidase
Endoribonuclease L-PSP/chorismate mutase-like
PHA accumulation regulator DNA-binding N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
DNA-directed DNA polymerase family A palm
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Signal transduction histidine kinase internal region
Carbamoyl-phosphate synthase small subunit N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Ribose-phosphate pyrophosphokinase N-terminal
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Helix-hairpin-helix DNA-binding motif class 1
Glucose-methanol-choline oxidoreductase N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Required for zinc-mediated homotetramerization and catalytic activity
Outer membrane protein assembly factor BamD
Alanyl-transfer RNA synthetases family profile
Bacterial type II secretion system protein E
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Gly-cisPro motif, important for rejection of L-amino acids
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Beta-lactamase hydrolase-like protein phosphatase-like
Ribosomal RNA adenine methylase transferase N-terminal
NADH-rubredoxin oxidoreductase C-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Type III secretion system flagellar brake protein YcgR PilZN
Phosphoadenosine phosphosulphate reductase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Alpha-glycerophosphate oxidase C-terminal
CNP1-like uncharacterized domain-containing protein
TonB-dependent receptor plug domain-containing protein
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
L,D-transpeptidase catalytic domain-containing protein
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Chromosomal replication initiator protein DnaA
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
RNA 2-O ribose methyltransferase substrate binding
Polymerase/histidinol phosphatase N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
NADH:ubiquinone oxidoreductase 30kDa subunit
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
ATP synthase F1 complex delta/epsilon subunit N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Translation elongation factor P/YeiP central
Alpha-D-phosphohexomutase alpha/beta/alpha
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Adaptive response protein AidB N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Pyrroline-5-carboxylate reductase dimerisation
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
UDP N-acetylglucosamine O-acyltransferase C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Transposase IS204/IS1001/IS1096/IS1165 DDE
O-(3'-phospho-DNA)-tyrosine intermediate
Peptidase C45 hydrolase domain-containing protein
Release factor glutamine methyltransferase N-terminal
ABC-type transport auxiliary lipoprotein component
ABC-type transport auxiliary lipoprotein component domain-containing protein
Heme-copper oxidase subunit III family profile
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
DNA polymerase III subunit delta C-terminal
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Type 4 fimbrial biogenesis protein PilX N-terminal
Glycine zipper domain-containing protein
Putative regulatory protein FmdB Zinc ribbon
CD-NTase-associated protein 12/Pycsar effector protein TIR
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Haem-binding uptake Tiki superfamily ChaN
Haem-binding uptake Tiki superfamily ChaN domain-containing protein
N-end rule aminoacyl transferase C-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Sodium symporter small subunit predicted
Ribosome maturation factor RimP N-terminal
Peptide methionine sulphoxide reductase MsrA
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Important for interaction with partner proteins
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Phosphate starvation-inducible protein PsiF
Pyruvate/ketoisovalerate oxidoreductase catalytic
Glycosyl transferase family 3 N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Pseudouridine synthase I TruA alpha/beta
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Type I restriction modification DNA specificity
Right handed beta helix domain-containing protein
Signal transduction histidine kinase dimerisation/phosphoacceptor
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Tetrahydrodipicolinate-N-succinyltransferase chain A
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Polysaccharide biosynthesis protein CapD-like
Adenylyl/Guanylyl and SMODS C-terminal sensor
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
AraC-type arabinose-binding/dimerisation
DNA mismatch repair proteins mutS family
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Alpha-carbonic anhydrase domain-containing protein
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Ribulose bisphosphate carboxylase large subunit C-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-91)
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Cation-transporting P-type ATPase N-terminal
Ionotropic glutamate receptor C-terminal