Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
S-adenosyl-L-homocysteine hydrolase NAD binding
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Glycine cleavage T-protein C-terminal barrel
RDXXRA motif of the pArg binding pocket involved in allosteric regulation
Bacterial transcription activator effector binding
Transposase IS116/IS110/IS902 C-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Tryptophan synthase beta chain-like PALP
Major facilitator superfamily (MFS) profile
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Glycosyltransferase subfamily 4-like N-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Pyruvate ferredoxin oxidoreductase beta subunit C-terminal
Thiamine pyrophosphate enzyme TPP-binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Prepilin type IV endopeptidase peptidase
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Solute-binding protein family 3/N-terminal
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Probable transposase IS891/IS1136/IS1341
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Positions MEP for the nucleophilic attack
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Schiff-base intermediate with acetaldehyde
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Flagellar assembly protein FliH/Type III secretion system HrpE
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
DNA mismatch repair proteins mutS family
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Putative aromatic acid exporter C-terminal
Threonine/serine exporter-like N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
SUF system FeS cluster assembly SufBD N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
O-(3'-phospho-DNA)-tyrosine intermediate
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Type I restriction modification DNA specificity
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
RNA polymerase sigma factor 70 region 4 type 2
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Involved in allosteric activation by GTP
Sporulation stage II protein D amidase enhancer LytB N-terminal
Phosphocysteine intermediate; for EIIB activity
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Aconitase A/isopropylmalate dehydratase small subunit swivel
RNA 2-O ribose methyltransferase substrate binding
Important for beta-aspartyl-AMP intermediate formation
Thiamine pyrophosphate enzyme N-terminal TPP-binding
NADH:flavin oxidoreductase/NADH oxidase N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Penicillin-binding protein transpeptidase
Flagellar hook-length control protein-like C-terminal
Urease accessory protein UreH-like transmembrane
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Phosphoribosylformylglycinamidine synthase linker
Mandelate racemase/muconate lactonizing enzyme C-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Pseudouridine synthase I TruA alpha/beta
Alpha-D-phosphohexomutase alpha/beta/alpha
Alpha-glycerophosphate oxidase C-terminal
Cell envelope-related transcriptional attenuator
Phosphatidylglycerol lysyltransferase C-terminal
Septum formation inhibitor MinC C-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Ionotropic glutamate receptor C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Thymidylate synthase/dCMP hydroxymethylase
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Small ribosomal subunit protein uS4 N-terminal
Resolvase/invertase-type recombinase catalytic
Prokaryotic-type class I peptide chain release factors
Polysaccharide biosynthesis protein C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Anthranilate synthase component I N-terminal
Membrane fusion protein biotin-lipoyl like
Ribosomal RNA adenine methylase transferase N-terminal
Sporulation transcription regulator WhiA N-terminal
6-phosphogluconate dehydrogenase C-terminal
Single-stranded-DNA-specific exonuclease RecJ C-terminal
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Flagellar motor switch protein FliN-like C-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Could be important to modulate the pK values of the two catalytic cysteine residues
Cytochrome b/b6 C-terminal region profile
Thiamin pyrophosphokinase thiamin-binding
NIF system FeS cluster assembly NifU N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Sodium/calcium exchanger membrane region
RND efflux pump membrane fusion protein barrel-sandwich
Essential for prephenate dehydratase activity
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
ABC transporter substrate-binding protein PnrA-like
Heme-copper oxidase subunit III family profile
Important for interaction with partner proteins
Phosphatidic acid phosphatase type 2/haloperoxidase
Pyrimidine nucleoside phosphorylase C-terminal
DNA-directed DNA polymerase family A palm
Global transcriptional regulator CodY C-terminal
Global transcriptional regulator CodY N-terminal
tRNA pseudouridylate synthase B C-terminal
Cobalamin-independent methionine synthase MetE N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
DnaJ homologue subfamily C member 28 conserved
Exonuclease VII large subunit C-terminal
Chromosomal replication initiator DnaA C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Menaquinone biosynthesis protein MenD middle
RNA binding; important for wobble base 34 recognition
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Shikimate dehydrogenase substrate binding N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Ribose-phosphate pyrophosphokinase N-terminal
Alanyl-transfer RNA synthetases family profile
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Peptidase S8/S53 domain-containing protein
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Sporulation stage IV protein A C-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Translation elongation factor P/YeiP central
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Tryptophan RNA-binding attenuator protein
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Cation-transporting P-type ATPase N-terminal
Helix-hairpin-helix DNA-binding motif class 1
CD-NTase-associated protein 12/Pycsar effector protein TIR
Cytochrome b/b6 N-terminal region profile
Large ribosomal subunit protein uL6 alpha-beta
Major facilitator superfamily associated
Polymerase/histidinol phosphatase N-terminal
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Peptide methionine sulphoxide reductase MsrA
Methylguanine DNA methyltransferase ribonuclease-like
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Sporulation initiation phosphotransferase B C-terminal
Polysaccharide biosynthesis protein CapD-like
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Magnesium transporter MgtE intracellular
Cytochrome C biogenesis protein transmembrane
Carbamoyl-phosphate synthase small subunit N-terminal
Glycoside hydrolase family 31 N-terminal
Diacylglycerol glucosyltransferase N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Lantibiotic immunity protein Spa1 C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Cysteine sulfenic acid (-SOH) intermediate
Gly-cisPro motif, important for rejection of L-amino acids
Interaction with polymerase core subunit RpoC
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Saccharopine dehydrogenase-like C-terminal
Large ribosomal subunit protein uL2 C-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Plays an important role in substrate specificity
Heat-inducible transcription repressor HrcA C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
UDP-N-acetylmuramoylalanine--D-glutamate ligase
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Inner membrane protein YgaP-like transmembrane
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Bacterial type II secretion system protein E
Glucosamine/galactosamine-6-phosphate isomerase
Peptidase S9 prolyl oligopeptidase catalytic
Nitrite/Sulfite reductase ferredoxin-like
Phosphotransferase system enzyme I N-terminal
Large ribosomal subunit protein uL15/eL18
Non-canonical purine NTP phosphatase/PRRC1
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
6-hydroxymethylpterin diphosphokinase MptE-like
Release factor glutamine methyltransferase N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Reversibly protonated during proton transport