Schiff-base intermediate with substrate; via pyruvic acid
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Large ribosomal subunit protein uL6 alpha-beta
Prepilin type IV endopeptidase peptidase
Prokaryotic-type class I peptide chain release factors
Tetrahydrodipicolinate-N-succinyltransferase chain A
Glycosyltransferase subfamily 4-like N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Aminoacyl-transfer RNA synthetases class-II family profile
Plays an important role in substrate specificity
Small ribosomal subunit protein uS4 N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Major facilitator superfamily (MFS) profile
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Molybdopterin cofactor biosynthesis C (MoaC)
RNA polymerase sigma factor 70 region 4 type 2
Inosine/uridine-preferring nucleoside hydrolase
Pyruvate dehydrogenase E1 component middle
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
DNA replication/recombination mediator RecO N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Penicillin-binding protein transpeptidase
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Membrane fusion protein biotin-lipoyl like
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Phosphotransferase system enzyme I N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Ribosomal RNA adenine methylase transferase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Gamma-butyrobetaine hydroxylase-like N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Curli production assembly/transport component CsgG
Pyruvate phosphate dikinase AMP/ATP-binding
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Interaction with polymerase core subunit RpoC
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
ATP synthase F1 complex delta/epsilon subunit N-terminal
Proline utilization A proline dehydrogenase N-terminal
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Electron transfer flavoprotein alpha/beta-subunit N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Essential for prephenate dehydratase activity
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Chromosomal replication initiator protein DnaA
Peptidase S9 prolyl oligopeptidase catalytic
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Tryptophan synthase beta chain-like PALP
Important for interaction with partner proteins
Outer membrane protein assembly factor BamE
Membrane insertase YidC/Oxa/ALB C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Alpha-D-phosphohexomutase alpha/beta/alpha
Transferrin-binding protein B C-lobe/N-lobe beta barrel
Transferrin-binding protein B C-lobe/N-lobe beta barrel domain-containing protein
Alanyl-transfer RNA synthetases family profile
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Nitrite/Sulfite reductase ferredoxin-like
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Bacterial type II secretion system protein E
Solute-binding protein family 3/N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Polysaccharide chain length determinant N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Trimeric autotransporter adhesin YadA-like C-terminal membrane anchor
Trimeric autotransporter adhesin YadA-like head
Trimeric autotransporter adhesin YadA-like stalk
RNA 2-O ribose methyltransferase substrate binding
Phosphatidic acid phosphatase type 2/haloperoxidase
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Polymerase/histidinol phosphatase N-terminal
Bacteriophage T7 Gp4 DNA primase/helicase N-terminal
Signal transduction histidine kinase internal region
DNA mismatch repair proteins mutS family
Electron transfer via tryptophanyl radical
Positions MEP for the nucleophilic attack
Bacterial transcription activator effector binding
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Survival protein SurE-like phosphatase/nucleotidase
Anthranilate synthase component I N-terminal
Exonuclease VII large subunit C-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
UDP N-acetylglucosamine O-acyltransferase C-terminal
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Outer membrane protein assembly factor BamA
Type 4 fimbrial biogenesis protein PilX N-terminal
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Glycine cleavage T-protein C-terminal barrel
Resolvase/invertase-type recombinase catalytic
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Involved in tetramerization or stability of the tetramer
Factor H binding protein C-terminal domain-containing protein
Reversibly protonated during proton transport
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
TonB-dependent receptor-like beta-barrel
Type IV pilus biogenesis and competence protein PilQ
Could be important to modulate the pK values of the two catalytic cysteine residues
S-adenosylmethionine-dependent methyltransferase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
YbaK/aminoacyl-tRNA synthetase-associated
Pseudouridine synthase I TruA alpha/beta
Thiol:disulfide interchange protein DsbA
Glucose-methanol-choline oxidoreductase N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Outer membrane protein assembly factor BamD
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Interacts with tRNA; defines subfamily-specific binding signature
Ionotropic glutamate receptor C-terminal
Sulfatase-modifying factor enzyme domain-containing protein
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
TonB C-terminal domain-containing protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Lytic transglycosylase superhelical linker
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Urease accessory protein UreH-like transmembrane
Chromosomal replication initiator DnaA C-terminal
Phosphoadenosine phosphosulphate reductase
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Shikimate dehydrogenase substrate binding N-terminal
Required for zinc-mediated homotetramerization and catalytic activity
Nucleophile; cysteine thiosulfonate intermediate
Large ribosomal subunit protein uL2 C-terminal
Integral membrane protein YccS N-terminal
Phosphoethanolamine transferase N-terminal
Type I restriction modification DNA specificity
N6 adenine-specific DNA methyltransferase N-terminal
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Polysaccharide biosynthesis protein C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Gly-cisPro motif, important for rejection of L-amino acids
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Cysteine sulfenic acid (-SOH) intermediate
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Sodium symporter small subunit predicted
O-(3'-phospho-DNA)-tyrosine intermediate
Carbamoyl-phosphate synthase small subunit N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Glycosyl transferase family 3 N-terminal
Metallo-beta-lactamase domain-containing protein
Lysozyme inhibitor LprI N-terminal domain-containing protein
Inner membrane protein YgaP-like transmembrane
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Arginine decarboxylase C-terminal helical
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Autotransporter domain-containing protein
Polysaccharide biosynthesis protein CapD-like
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
ABC-type transport auxiliary lipoprotein component
Large ribosomal subunit protein uL15/eL18
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Disulphide bond isomerase DsbC/G N-terminal
6-phosphogluconate dehydrogenase C-terminal
Phage terminase large subunit C-terminal
Phage terminase large subunit N-terminal
Beta-lactamase hydrolase-like protein phosphatase-like
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Virulence factor membrane-bound polymerase C-terminal
Thiol:disulfide interchange protein DsbD
NADH:ubiquinone oxidoreductase chain 4 N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Acyl-CoA dehydrogenase C-terminal bacterial-type
RNA binding; important for wobble base 34 recognition
Translation elongation factor P/YeiP central
NIF system FeS cluster assembly NifU N-terminal