Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Tat pathway signal sequence domain protein
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Integral membrane protein YccS N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
N6 adenine-specific DNA methyltransferase N-terminal
ABC transporter substrate-binding protein PnrA-like
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Glycosyltransferase subfamily 4-like N-terminal
Major facilitator superfamily (MFS) profile
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Peptidase M1 membrane alanine aminopeptidase
Sigma 54 modulation/S30EA ribosomal protein C-terminal
LPXTG cell wall anchor domain-containing protein
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Acyl-CoA dehydrogenase/oxidase C-terminal
Adaptive response protein AidB N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
RNA polymerase sigma factor 70 region 4 type 2
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
RNA 2-O ribose methyltransferase substrate binding
Solute-binding protein family 3/N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Alpha-D-phosphohexomutase alpha/beta/alpha
Tryptophan synthase beta chain-like PALP
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
4'-phosphopantetheinyl transferase N-terminal
Plays an important role in substrate specificity
Acyl-CoA dehydrogenase/oxidase N-terminal
Exonuclease VII large subunit C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Bacterial type II secretion system protein E
Important for beta-aspartyl-AMP intermediate formation
Penicillin-binding protein transpeptidase
Streptomyces killer toxin-like beta/gamma crystallin domain-containing protein
Important for substrate specificity; cannot use PPi as phosphoryl donor
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Prokaryotic-type class I peptide chain release factors
Sodium/calcium exchanger membrane region
UDP-glucose/GDP-mannose dehydrogenase C-terminal
MmyB-like transcription regulator ligand binding
Mycothiol-dependent maleylpyruvate isomerase metal-binding
DNA primase/polymerase bifunctional N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Glucosamine/galactosamine-6-phosphate isomerase
Could be important to modulate the pK values of the two catalytic cysteine residues
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Glycoside-hydrolase family GH114 TIM-barrel
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Thiopeptide-type bacteriocin biosynthesis
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Gram-positive cocci surface proteins LPxTG
Thymidylate synthase/dCMP hydroxymethylase
Polymerase/histidinol phosphatase N-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Ribosomal RNA adenine methylase transferase N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Tetracyclin repressor-like C-terminal group 31
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Formamidopyrimidine-DNA glycosylase catalytic
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
NADH:ubiquinone oxidoreductase 30kDa subunit
Methionyl-tRNA synthetase anticodon-binding
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Peptide methionine sulphoxide reductase MsrA
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Putative glycogen debranching enzyme N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
YbaK/aminoacyl-tRNA synthetase-associated
Gly-cisPro motif, important for rejection of L-amino acids
Pyridoxamine 5'-phosphate oxidase putative
Phosphoadenosine phosphosulphate reductase
Quercetin 2,3-dioxygenase C-terminal cupin
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Pyruvate dehydrogenase E1 component middle
Alpha-glycerophosphate oxidase C-terminal
Translation elongation factor P/YeiP central
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Transposase IS116/IS110/IS902 C-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
6-phosphogluconate dehydrogenase C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Pyrimidine nucleoside phosphorylase C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
O-(5'-phospho-DNA)-tyrosine intermediate
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Pseudouridine synthase I TruA alpha/beta
DNA-directed DNA polymerase family A palm
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Heat-inducible transcription repressor HrcA C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Styrene monooxygenase StyA putative substrate binding
Nucleophile; cysteine thiosulfonate intermediate
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal domain-containing protein
Positions MEP for the nucleophilic attack
Essential for prephenate dehydratase activity
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Cell envelope-related transcriptional attenuator
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Acyltransferase MbtK/IucB-like conserved
Bacterial bifunctional deaminase-reductase C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Cytochrome bc1 complex cytochrome c subunit
DnaJ homologue subfamily C member 28 conserved
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Glycine cleavage T-protein C-terminal barrel
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Ionotropic glutamate receptor C-terminal
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Sporulation transcription regulator WhiA N-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Phosphatidylglycerol lysyltransferase C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Cell wall-active antibiotics response LiaF-like C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Diacylglycerol glucosyltransferase N-terminal
Prepilin type IV endopeptidase peptidase
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Electron transfer via tryptophanyl radical
Probable subtilase-type protease inhibitor
Saccharopine dehydrogenase-like C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Involved in allosteric activation by GTP
Nicotinate phosphoribosyltransferase N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
NIF system FeS cluster assembly NifU C-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
N,N-dimethylformamidase beta subunit-like C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
ATP synthase F1 complex delta/epsilon subunit N-terminal
Haemophore haem-binding domain-containing protein
Molybdopterin cofactor biosynthesis C (MoaC)
Na+/H+ antiporter MnhB subunit-related protein
Heme-copper oxidase subunit III family profile
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Histidine-specific methyltransferase SAM-dependent
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Phosphomannose isomerase type I catalytic
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Proton acceptor; for glutaminase activity
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Large ribosomal subunit protein uL15/eL18
Phosphoribosylformylglycinamidine synthase linker
Membrane insertase YidC/Oxa/ALB C-terminal
Large ribosomal subunit protein uL2 C-terminal
Schiff-base intermediate with D-ribose 5-phosphate
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Putative oxidoreductase/dehydrogenase Rossmann-like
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Lactate utilization protein B C-terminal
Glycoside hydrolase family 31 N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Anthranilate synthase component I N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
Beta-hexosaminidase bacterial type N-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Removed in mature form; by autocatalysis
SUF system FeS cluster assembly SufBD N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Glycosyl transferase family 3 N-terminal
ABC-type glycine betaine transport system substrate-binding
Threonine/serine exporter-like N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Ribose-phosphate pyrophosphokinase N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Lantibiotic biosynthesis protein dehydration
Glutathionylspermidine synthase pre-ATP-grasp-like
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Transcription regulator AsnC/Lrp ligand binding
Beta-lactamase class A catalytic domain-containing protein
Cytochrome bc1 complex Rieske iron-sulfur subunit
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
CobB/CobQ-like glutamine amidotransferase
Interaction with polymerase core subunit RpoC
Rv2525c-like glycoside hydrolase-like domain-containing protein
Pyruvate phosphate dikinase AMP/ATP-binding
Type ISP restriction-modification enzyme LLaBIII C-terminal specificity
Cytochrome b/b6 N-terminal region profile
Reversibly protonated during proton transport
Endoribonuclease L-PSP/chorismate mutase-like
Phosphocysteine intermediate; for EIIB activity
DNA replication/recombination mediator RecO N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Shikimate dehydrogenase substrate binding N-terminal
Erythromycin biosynthesis protein CIII-like central
Carbamoyl-phosphate synthase small subunit N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Phosphotransferase system enzyme I N-terminal
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
Pyrroline-5-carboxylate reductase dimerisation
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Release factor glutamine methyltransferase N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Small ribosomal subunit protein uS4 N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-109)
N-acetylneuraminic acid synthase N-terminal
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Lysyl-tRNA synthetase N-terminal transmembrane region
non-reducing end alpha-L-arabinofuranosidase
Alanyl-transfer RNA synthetases family profile
Cytochrome oxidase subunit II copper A binding
L-seryl-tRNA selenium transferase N-terminal
PhoD-like phosphatase metallophosphatase
Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Inosine/uridine-preferring nucleoside hydrolase