Major facilitator superfamily (MFS) profile
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Thymidylate synthase/dCMP hydroxymethylase
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Phosphocysteine intermediate; for EIIB activity
Type III secretion system flagellar brake protein YcgR PilZN
Copper amine oxidase-like N-terminal domain-containing protein
Na+-translocating membrane potential-generating system MpsC
RNA 2-O ribose methyltransferase substrate binding
Glycine cleavage T-protein C-terminal barrel
Polymerase/histidinol phosphatase N-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
O-(5'-phospho-DNA)-tyrosine intermediate
Lipoprotein LpqB beta-propeller domain-containing protein
Endoribonuclease L-PSP/chorismate mutase-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Glycosyltransferase subfamily 4-like N-terminal
Peptide methionine sulphoxide reductase MsrA
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Thiamin pyrophosphokinase thiamin-binding
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Aminoacyl-transfer RNA synthetases class-II family profile
SUF system FeS cluster assembly SufBD N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Cation-transporting P-type ATPase N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Penicillin-binding protein transpeptidase
RCC1 repeat-and reductase domain-containing protein
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Diacylglycerol glucosyltransferase N-terminal
Glycosyl transferase family 28 C-terminal
Chromosomal replication initiator DnaA C-terminal
Polysaccharide biosynthesis protein C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
NIF system FeS cluster assembly NifU C-terminal
Single-stranded-DNA-specific exonuclease RecJ C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Glycosyltransferase family 28 N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Saccharopine dehydrogenase-like C-terminal
NIF system FeS cluster assembly NifU N-terminal
D-galactose/methyl-galactoside binding periplasmic protein MglB
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
Resolvase/invertase-type recombinase catalytic
Solute-binding protein family 3/N-terminal
Solute-binding protein family 3/N-terminal domain-containing protein
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Glycosyl transferase family 3 N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Tryptophan synthase beta chain-like PALP
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Tryptophan RNA-binding attenuator protein
RNA binding; important for wobble base 34 recognition
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Photosynthesis system II assembly factor Ycf48/Hcf136-like
Photosynthesis system II assembly factor Ycf48/Hcf136-like domain-containing protein
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Periplasmic binding protein domain-containing protein
Involved in allosteric activation by GTP
Pseudouridine synthase I TruA alpha/beta
ABC transporter substrate-binding protein
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Interaction with polymerase core subunit RpoC
Phosphomannose isomerase type I catalytic
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Cell envelope-related transcriptional attenuator
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Large ribosomal subunit protein uL2 C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
BREX system Lon protease-like BrxL N-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Alpha-L-arabinofuranosidase B arabinose-binding
Mannose-6-phosphate isomerase type II C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Glycoside hydrolase family 31 N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Transcriptional regulator SgrR N-terminal HTH
RNA polymerase sigma factor 70 region 4 type 2
Positions MEP for the nucleophilic attack
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
S-adenosylmethionine-dependent methyltransferase
Acyl-CoA dehydrogenase/oxidase N-terminal
ABC transporter substrate-binding protein PnrA-like
ABC transporter substrate-binding protein PnrA-like domain-containing protein
Transposase IS116/IS110/IS902 C-terminal
Large ribosomal subunit protein uL15/eL18
Bacterial type II secretion system protein E
Activator of Hsp90 ATPase homologue 1-like C-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Heme-copper oxidase subunit III family profile
D-galactarate/Altronate dehydratase C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Cysteine sulfenic acid (-SOH) intermediate
Phosphotransferase system enzyme I N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Peptidase S9 prolyl oligopeptidase catalytic
Bacterial transcription activator effector binding
Cytochrome C biogenesis protein transmembrane
Peptidase M1 membrane alanine aminopeptidase
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Phosphatidylglycerol lysyltransferase C-terminal
Flagellar hook-length control protein-like C-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Important for beta-aspartyl-AMP intermediate formation
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Terminase large subunit gp17-like C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Alpha-glycerophosphate oxidase C-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Protein-PII uridylyltransferase N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Flagellar motor switch protein FliN-like C-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
6-hydroxymethylpterin diphosphokinase MptE-like
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Glycoside hydrolase family 42 N-terminal
Beta-xylosidase C-terminal Concanavalin A-like
Glyoxalase/fosfomycin resistance/dioxygenase
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Dipicolinate synthase subunit A N-terminal
General stress protein FMN-binding split barrel
Ionotropic glutamate receptor C-terminal
Sodium/calcium exchanger membrane region
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Membrane insertase YidC/Oxa/ALB C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Alanyl-transfer RNA synthetases family profile
Sporulation stage IV protein A C-terminal
SsuA/THI5-like domain-containing protein
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Sporulation transcription regulator WhiA N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Essential for prephenate dehydratase activity
Alpha-galactosidase NEW3 domain-containing protein
Fe/B12 periplasmic-binding domain-containing protein
Polysaccharide biosynthesis protein CapD-like
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
ATP synthase F1 complex delta/epsilon subunit N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Transcription regulator AsnC/Lrp ligand binding
Cobalamin-independent methionine synthase MetE N-terminal
ABC-type glycine betaine transport system substrate-binding
CRISPR-associated protein Cas6 C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Glycoside hydrolase family 38 N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
DNA replication/recombination mediator RecO N-terminal
Pyruvate ferredoxin oxidoreductase beta subunit C-terminal
DNA mismatch repair proteins mutS family
HTH-type transcriptional regulator MT1864/Rv1816-like C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Beta-hexosaminidase bacterial type N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Septum formation inhibitor MinC C-terminal
Anthranilate synthase component I N-terminal
6-phosphogluconate dehydrogenase C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Peptide methionine sulfoxide reductase MsrA
Translation elongation factor P/YeiP central
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
EfeO-type cupredoxin-like domain-containing protein
X-Prolyl dipeptidyl aminopeptidase PepX N-terminal
Glycosyl hydrolase family 30 beta sandwich
Prepilin type IV endopeptidase peptidase
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Alpha galactosidase C-terminal beta sandwich
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
N-sulphoglucosamine sulphohydrolase C-terminal
N-acetylneuraminic acid synthase N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Large ribosomal subunit protein uL30-like ferredoxin-like fold
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Moves into active site upon enzyme activation, plays a role in electron transfer
Putative aromatic acid exporter C-terminal
Type III restriction enzyme C-terminal endonuclease
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glycerol-3-phosphate dehydrogenase [NAD(P)+]
Calcineurin-like phosphoesterase domain-containing protein
Reversibly protonated during proton transport
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Elongation factor G-binding protein N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Flagellar Assembly Protein A N-terminal region
Pyruvate/ketoisovalerate oxidoreductase catalytic
Polysaccharide chain length determinant N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Important for interaction with partner proteins
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Small ribosomal subunit protein uS4 N-terminal
Kanamycin nucleotidyltransferase C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Plays an important role in substrate specificity
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Bulb-type lectin domain-containing protein
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Succinate dehydogenase/fumarate reductase N-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Schiff-base intermediate with acetaldehyde
Spore germination GerAC-like C-terminal domain-containing protein
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Shikimate dehydrogenase substrate binding N-terminal
Signal transduction histidine kinase internal region
Threonine/serine exporter-like N-terminal