Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Important for interaction with partner proteins
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Nucleoside phosphorylase domain-containing protein
Major facilitator superfamily (MFS) profile
Glycosyl transferase family 3 N-terminal
Polymerase/histidinol phosphatase N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Resolvase/invertase-type recombinase catalytic
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Polysaccharide chain length determinant N-terminal
Tryptophan RNA-binding attenuator protein
Peptidase S9 prolyl oligopeptidase catalytic
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
6-phosphogluconate dehydrogenase NADP-binding
RNA polymerase sigma factor 70 region 4 type 2
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Tryptophan synthase beta chain-like PALP
Positions MEP for the nucleophilic attack
Penicillin-binding protein transpeptidase
Ribosomal RNA adenine methylase transferase N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
O-(3'-phospho-DNA)-tyrosine intermediate
Na+/H+ antiporter MnhB subunit-related protein
Ribose-phosphate pyrophosphokinase N-terminal
Thiamin pyrophosphokinase thiamin-binding
TRAP C4-dicarboxylate transport system permease DctM subunit
Superoxide dismutase copper/zinc binding
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Fe/B12 periplasmic-binding domain-containing protein
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Pyridoxamine 5'-phosphate oxidase putative
O-(5'-phospho-DNA)-tyrosine intermediate
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Schiff-base intermediate with acetaldehyde
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
DNA polymerase III beta sliding clamp central
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Phosphocysteine intermediate; for EIIB activity
Cell envelope-related transcriptional attenuator
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Gly-cisPro motif, important for rejection of L-amino acids
Sporulation transcription regulator WhiA N-terminal
Glyoxalase/fosfomycin resistance/dioxygenase
Large ribosomal subunit protein uL2 C-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Heme-copper oxidase subunit III family profile
Alanyl-transfer RNA synthetases family profile
Essential for prephenate dehydratase activity
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Heat-inducible transcription repressor HrcA C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Aminoacyl-transfer RNA synthetases class-II family profile
Alpha-D-phosphohexomutase alpha/beta/alpha
Septum formation inhibitor MinC C-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Sporulation stage II protein D amidase enhancer LytB N-terminal
Important for beta-aspartyl-AMP intermediate formation
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Chromosomal replication initiator DnaA C-terminal
6-phosphogluconate dehydrogenase C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Dipicolinate synthase subunit A N-terminal
Plays an important role in substrate specificity
Microcin J25-processing protein McjB C-terminal
Reversibly protonated during proton transport
Polysaccharide biosynthesis protein CapD-like
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Schiff-base intermediate with D-ribose 5-phosphate
Activator of Hsp90 ATPase homologue 1-like C-terminal
Prokaryotic-type class I peptide chain release factors
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Pseudouridine synthase I TruA alpha/beta
RNA 2-O ribose methyltransferase substrate binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Signal transduction histidine kinase internal region
Glycosyltransferase subfamily 4-like N-terminal
General stress protein FMN-binding split barrel
Exonuclease VII large subunit C-terminal
Anthranilate synthase component I N-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Phage conserved hypothetical protein C-terminal
DNA mismatch repair proteins mutS family
YbaK/aminoacyl-tRNA synthetase-associated
SGNH hydrolase-type esterase domain-containing protein
SUF system FeS cluster assembly SufBD N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Polysaccharide biosynthesis protein C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Translation elongation factor P/YeiP central
Cation-transporting P-type ATPase N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Cytochrome b/b6 N-terminal region profile
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Large ribosomal subunit protein uL15/eL18
Small ribosomal subunit protein uS4 N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
NADH:flavin oxidoreductase/NADH oxidase N-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Pyrimidine nucleoside phosphorylase C-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Aconitase A/isopropylmalate dehydratase small subunit swivel
Glycoside hydrolase family 31 N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Putative aromatic acid exporter C-terminal
RDXXRA motif of the pArg binding pocket involved in allosteric regulation
Positions ribitol 5-phosphate for the nucleophilic attack
Bacterial transcription activator effector binding
Terminase large subunit-like endonuclease
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
Diacylglycerol glucosyltransferase N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
TarS beta-glycosyltransferase C-terminal
DNA polymerase III delta subunit C-terminal
Single-stranded-DNA-specific exonuclease RecJ C-terminal
Peptide methionine sulphoxide reductase MsrA
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Styrene monooxygenase StyA putative substrate binding
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Cytochrome b/b6 C-terminal region profile
Membrane insertase YidC/Oxa/ALB C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Global transcriptional regulator CodY C-terminal
Global transcriptional regulator CodY N-terminal
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Glucosamine/galactosamine-6-phosphate isomerase
Mannose-6-phosphate isomerase type II C-terminal
Release factor glutamine methyltransferase N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
PhoD-like phosphatase metallophosphatase
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Cysteine sulfenic acid (-SOH) intermediate
Type III secretion system flagellar brake protein YcgR PilZN
Large ribosomal subunit protein uL6 alpha-beta
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Sporulation initiation phosphotransferase B C-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Cytochrome C biogenesis protein transmembrane
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Na+-translocating membrane potential-generating system MpsC
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Intracellular proteinase inhibitor BsuPI
ABC transporter substrate-binding protein PnrA-like
ABC transporter substrate-binding protein PnrA-like domain-containing protein
Phosphotransferase system enzyme I N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Putative component of 'biosynthetic module'
Lysidine-tRNA(Ile) synthetase C-terminal
Alpha-glycerophosphate oxidase C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Phosphoribosylformylglycinamidine synthase linker
Molybdopterin cofactor biosynthesis C (MoaC)
DNA replication/recombination mediator RecO N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Survival protein SurE-like phosphatase/nucleotidase
Magnesium transporter MgtE intracellular
Bacterial type II secretion system protein E
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Inosine/uridine-preferring nucleoside hydrolase
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Polysaccharide lyase 8 N-terminal alpha-helical
Polysaccharide lyase family 8 C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Prepilin type IV endopeptidase peptidase
Flagellar motor switch protein FliN-like C-terminal
Sodium/calcium exchanger membrane region
Glycoside hydrolase family 42 N-terminal
Glycoside hydrolase family 42 N-terminal domain-containing protein
RNA binding; important for wobble base 34 recognition
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Deacetylase PdaC domain-containing protein
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
NIF system FeS cluster assembly NifU N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
3-beta hydroxysteroid dehydrogenase/isomerase
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Solute-binding protein family 5 domain-containing protein
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Metallo-beta-lactamase domain-containing protein
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Elongation factor G-binding protein N-terminal
Gram-positive cocci surface proteins LPxTG
Involved in allosteric activation by GTP
DnaJ homologue subfamily C member 28 conserved
Interaction with polymerase core subunit RpoC
Inner membrane protein YgaP-like transmembrane
ATP synthase F1 complex delta/epsilon subunit N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
DNA-directed DNA polymerase family A palm
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
ABC-type glycine betaine transport system substrate-binding
Glycine cleavage T-protein C-terminal barrel
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Peptidase M15B domain-containing protein
Sporulation stage IV protein A C-terminal
D-galactarate/Altronate dehydratase C-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)