DNA replication/recombination mediator RecO N-terminal
Major facilitator superfamily (MFS) profile
Curli production assembly/transport component CsgG
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
TonB-dependent receptor-like beta-barrel
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Gp5/Type VI secretion system Vgr protein OB-fold
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Translation elongation factor EFTs/EF1B dimerisation
Essential for prephenate dehydratase activity
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Large ribosomal subunit protein uL6 alpha-beta
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Signal transduction histidine kinase internal region
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
DNA-directed DNA polymerase family A palm
Bacteriophage tail tape measure C-terminal
Bacteriophage tail tape measure N-terminal
Fimbrial-type adhesion domain-containing protein
Activator of Hsp90 ATPase homologue 1-like C-terminal
Tryptophan synthase beta chain-like PALP
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
N-end rule aminoacyl transferase C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Bacterial type II secretion system protein E
Cysteine sulfenic acid (-SOH) intermediate
Glycosyltransferase subfamily 4-like N-terminal
NIF system FeS cluster assembly NifU C-terminal
C-type lysozyme inhibitor domain-containing protein
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Alpha-glycerophosphate oxidase C-terminal
Translation elongation factor P/YeiP central
Peptidase S9 prolyl oligopeptidase catalytic
Ysc84 actin-binding domain-containing protein
Inosine/uridine-preferring nucleoside hydrolase
Spore coat protein U domain-containing protein
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Coagulation factor 5/8 type domain-containing protein
Ricin B lectin domain-containing protein
RNA polymerase sigma factor 70 region 4 type 2
Outer membrane protein OmpA-like transmembrane
Outer membrane protein OmpA-like transmembrane domain-containing protein
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Outer membrane lipoprotein carrier protein LolA
Flagellar basal body rod protein N-terminal
Disulphide bond isomerase DsbC/G N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Penicillin-binding protein transpeptidase
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS domain-containing protein
Glutathionylspermidine synthase pre-ATP-grasp-like
Putative adhesin domain-containing protein
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Large ribosomal subunit protein uL2 C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Mechanosensitive ion channel protein MscS
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
NADH:ubiquinone oxidoreductase 30kDa subunit
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Interaction with polymerase core subunit RpoC
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Key residue in conferring substrate specificity for N-acetyl-L-ornithine versus N-succinyl-L-ornithine
UDP N-acetylglucosamine O-acyltransferase C-terminal
PHA accumulation regulator DNA-binding N-terminal
Polysaccharide biosynthesis protein C-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Flagellar basal-body/hook protein C-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
6-phosphogluconate dehydrogenase C-terminal
Dienelactone hydrolase domain-containing protein
SGNH hydrolase-type esterase domain-containing protein
Lysidine-tRNA(Ile) synthetase C-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Peptidase M1 membrane alanine aminopeptidase
Thymidylate synthase/dCMP hydroxymethylase
ABC transporter substrate-binding protein
RND efflux pump membrane fusion protein barrel-sandwich
Lipocalin-like domain-containing protein
O-(5'-phospho-DNA)-tyrosine intermediate
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Outer membrane protein assembly factor BamA
TonB-dependent receptor plug domain-containing protein
Lipoprotein SmpA/OmlA domain-containing protein
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Sodium/calcium exchanger membrane region
Polysaccharide biosynthesis protein CapD-like
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glycerol-3-phosphate dehydrogenase [NAD(P)+]
Phosphatidylinositol diacylglycerol-lyase
Fe/B12 periplasmic-binding domain-containing protein
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Required for dimer formation and molybdate binding
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Exonuclease VII large subunit C-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Chitin-binding type-3 domain-containing protein
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
Chromosomal replication initiator protein DnaA
Translocation and assembly module subunit TamA
Alanyl-transfer RNA synthetases family profile
Bacterial bifunctional deaminase-reductase C-terminal
Putative regulatory protein FmdB Zinc ribbon
Flagellar hook-length control protein-like C-terminal
Glycosyltransferase RgtA/B/C/D-like domain-containing protein
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
L,D-transpeptidase catalytic domain-containing protein
Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein
Fibronectin type-III domain-containing protein
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Outer membrane protein beta-barrel domain-containing protein
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Putative beta-barrel assembly-enhancing protease
Delta-60 repeat domain-containing protein
Trigger factor ribosome-binding bacterial
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
RNA binding; important for wobble base 34 recognition
Lysine-specific metallo-endopeptidase domain-containing protein
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Pyruvate dehydrogenase E1 component middle
Outer membrane protein assembly factor BamB
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Anthranilate synthase component I N-terminal
AB hydrolase-1 domain-containing protein
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Membrane insertase YidC/Oxa/ALB C-terminal
Ribonucleotide reductase large subunit C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Bacterial surface antigen (D15) domain-containing protein
Prepilin type IV endopeptidase peptidase
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Autotransporter domain-containing protein
Positions MEP for the nucleophilic attack
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Beta-lactamase-related domain-containing protein
Mandelate racemase/muconate lactonizing enzyme C-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Flagella basal body P-ring formation protein FlgA
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Polysaccharide chain length determinant N-terminal
L-seryl-tRNA selenium transferase N-terminal
Type II secretion system protein GspG C-terminal
Plays an important role in discriminating NADH against NADPH
Resolvase/invertase-type recombinase catalytic
Peptide methionine sulfoxide reductase MsrA
Peptide methionine sulphoxide reductase MsrA
Peptidase M12B domain-containing protein
Glycine zipper 2TM domain-containing protein
Membrane fusion protein biotin-lipoyl like
Pseudouridine synthase I TruA alpha/beta
Lysozyme inhibitor LprI N-terminal domain-containing protein
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Antitoxin Xre/MbcA/ParS-like toxin-binding
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Alpha-D-phosphohexomutase alpha/beta/alpha
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Arginine decarboxylase C-terminal helical
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Lytic transglycosylase superhelical linker
Pyridine nucleotide-disulphide oxidoreductase dimerisation
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Cation-transporting P-type ATPase N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Beta-hexosaminidase bacterial type N-terminal
Biopterin-dependent aromatic amino acid hydroxylase family profile
Acyl-CoA dehydrogenase C-terminal bacterial-type
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
PsbP C-terminal domain-containing protein
DNA mismatch repair proteins mutS family
Phosphoethanolamine transferase N-terminal
Superoxide dismutase copper/zinc binding
Calcineurin-like phosphoesterase domain-containing protein
Glycine cleavage T-protein C-terminal barrel
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid
Integral membrane protein YccS N-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
High potential iron-sulfur proteins family profile
Quercetin 2,3-dioxygenase C-terminal cupin
Glycosyl-hydrolase 97 C-terminal oligomerisation
Type 4 fimbrial biogenesis protein PilX N-terminal
Phosphotransferase system enzyme I N-terminal
Proton acceptor; for glutaminase activity
Tetrahydrodipicolinate-N-succinyltransferase chain A
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Metallo-beta-lactamase domain-containing protein
General stress protein FMN-binding split barrel
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Adaptive response protein AidB N-terminal
Chromosomal replication initiator DnaA C-terminal
Prokaryotic-type class I peptide chain release factors
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Gfo/Idh/MocA-like oxidoreductase bacterial type C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
TtsA-like Glycoside hydrolase family 108
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
Involved in tetramerization or stability of the tetramer
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Transglutaminase-like domain-containing protein
Beta/gamma crystallin 'Greek key' domain-containing protein
RNA 2-O ribose methyltransferase substrate binding
Helix-hairpin-helix DNA-binding motif class 1
Phosphatidic acid phosphatase type 2/haloperoxidase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Outer membrane protein assembly factor BamD
ABC-type transport auxiliary lipoprotein component
ABC-type transport auxiliary lipoprotein component domain-containing protein
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Electron transfer via tryptophanyl radical
Mannose-6-phosphate isomerase type II C-terminal
Important for beta-aspartyl-AMP intermediate formation
Interacts with tRNA; defines subfamily-specific binding signature
Glycosyl transferase family 3 N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Small ribosomal subunit protein uS4 N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Nicotinamide phosphoribosyltransferase N-terminal
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
3-keto-disaccharide hydrolase domain-containing protein
Aromatic hydrocarbon degradation protein
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Peptidase M3A/M3B catalytic domain-containing protein
Flagellar motor switch protein FliN-like C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Type VI secretion system IcmF C-terminal
Plays an important role in substrate specificity
Required for zinc-mediated homotetramerization and catalytic activity
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Shikimate dehydrogenase substrate binding N-terminal
Large ribosomal subunit protein uL15/eL18
Survival protein SurE-like phosphatase/nucleotidase
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Reversibly protonated during proton transport
Non-canonical purine NTP phosphatase/PRRC1
S-adenosyl-L-homocysteine hydrolase NAD binding
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
TonB-dependent receptor-like beta-barrel domain-containing protein
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Maltose operon substrate-binding protein (MalM)
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Heme-copper oxidase subunit III family profile
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Ribosomal RNA small subunit methyltransferase E methyltransferase
Gly-cisPro motif, important for rejection of L-amino acids
Polypeptide-transport-associated ShlB-type
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-91)
PilC beta-propeller domain-containing protein
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Release factor glutamine methyltransferase N-terminal
Polymerase/histidinol phosphatase N-terminal
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Aspartate/homoserine dehydrogenase NAD-binding
Peptidase S8/S53 domain-containing protein
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Carbamoyl-phosphate synthase small subunit N-terminal
Important for substrate binding and specificity
Outer-membrane lipoprotein carrier protein
Moves into active site upon enzyme activation, plays a role in electron transfer
Threonine/serine exporter-like N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Gamma-butyrobetaine hydroxylase-like N-terminal
Bacterial NAD-glutamate dehydrogenase N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
CagE TrbE VirB component of type IV transporter system central
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Histidine-specific methyltransferase SAM-dependent
Murein L,D-transpeptidase catalytic domain family protein
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Xylose isomerase-like TIM barrel domain-containing protein
DNA topoisomerase I catalytic core eukaryotic-type
ABC-type uncharacterised transport system