S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Penicillin-binding protein transpeptidase
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Cytochrome oxidase subunit II copper A binding
Phosphomannose isomerase type I catalytic
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Resuscitation-promoting factor Rpf1 C-terminal
Resuscitation-promoting factor core lysozyme-like
Polymerase/histidinol phosphatase N-terminal
Large ribosomal subunit protein uL2 C-terminal
Translation elongation factor P/YeiP central
NIF system FeS cluster assembly NifU C-terminal
DNA replication/recombination mediator RecO N-terminal
L,D-transpeptidase catalytic domain-containing protein
Gly-cisPro motif, important for rejection of L-amino acids
Pyridine nucleotide-disulphide oxidoreductase dimerisation
RNA 2-O ribose methyltransferase substrate binding
Tryptophan synthase beta chain-like PALP
Glycosyl transferase family 3 N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Phosphocysteine intermediate; for EIIB activity
Aminoacyl-transfer RNA synthetases class-II family profile
Heat-inducible transcription repressor HrcA C-terminal
Major facilitator superfamily (MFS) profile
4'-phosphopantetheinyl transferase N-terminal
Solute-binding protein family 3/N-terminal
Septum formation-related domain-containing protein
Plays an important role in substrate specificity
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Glycine cleavage T-protein C-terminal barrel
Helix-hairpin-helix DNA-binding motif class 1
Cytochrome b/b6 N-terminal region profile
Electron transfer flavoprotein alpha/beta-subunit N-terminal
SsuA/THI5-like domain-containing protein
Type I restriction enzyme R protein N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
PhoD-like phosphatase metallophosphatase
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Cell envelope-related transcriptional attenuator
Reversibly protonated during proton transport
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Threonine/serine exporter-like N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Anthranilate synthase component I N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Prokaryotic-type class I peptide chain release factors
Formamidopyrimidine-DNA glycosylase catalytic
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
RNA polymerase sigma factor 70 region 4 type 2
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Trigger factor ribosome-binding bacterial
Nitrite/Sulfite reductase ferredoxin-like
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Molybdopterin cofactor biosynthesis C (MoaC)
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
ABC transporter substrate-binding protein
Small ribosomal subunit protein uS4 N-terminal
Glycosyltransferase subfamily 4-like N-terminal
RNA binding; important for wobble base 34 recognition
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Phosphotransferase system enzyme I N-terminal
Gram-positive cocci surface proteins LPxTG
Glucosamine/galactosamine-6-phosphate isomerase
TRAP C4-dicarboxylate transport system permease DctM subunit
Alanyl-transfer RNA synthetases family profile
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Thymidylate synthase/dCMP hydroxymethylase
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Sporulation transcription regulator WhiA N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Ribosome maturation factor RimP N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Cysteine sulfenic acid (-SOH) intermediate
Schiff-base intermediate with D-ribose 5-phosphate
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Schiff-base intermediate with substrate; via pyruvic acid
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Aminoacyl-tRNA synthetase class I anticodon-binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Restriction system protein Mrr-like N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Chromosomal replication initiator DnaA C-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
CobB/CobQ-like glutamine amidotransferase
ATP synthase F1 complex delta/epsilon subunit N-terminal
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
S-adenosyl-L-homocysteine hydrolase NAD binding
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Gram-positive pilin subunit D1 N-terminal
ABC-type glycine betaine transport system substrate-binding domain-containing protein
Prealbumin-like fold domain-containing protein
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Peptide methionine sulphoxide reductase MsrA
Mandelate racemase/muconate lactonizing enzyme C-terminal
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Exonuclease VII large subunit C-terminal
Schiff-base intermediate with acetaldehyde
Large ribosomal subunit protein uL15/eL18
Cytochrome b561 bacterial/Ni-hydrogenase
Important for substrate specificity; cannot use PPi as phosphoryl donor
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Mycothiol-dependent maleylpyruvate isomerase metal-binding
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Important for beta-aspartyl-AMP intermediate formation
YbaK/aminoacyl-tRNA synthetase-associated
Peptidase S9 prolyl oligopeptidase catalytic
NIF system FeS cluster assembly NifU N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Involved in ionization of N3 of dUMP, leading to its activation
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Ribosomal RNA adenine methylase transferase N-terminal
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Interaction with polymerase core subunit RpoC
Large ribosomal subunit protein uL30-like ferredoxin-like fold
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Peptidase M1 membrane alanine aminopeptidase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase