Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Bacterial bifunctional deaminase-reductase C-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Proteinase inhibitor I42 chagasin domain-containing protein
RNA polymerase sigma factor 70 region 4 type 2
Major facilitator superfamily (MFS) profile
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Molybdopterin cofactor biosynthesis C (MoaC)
Myo-inositol-1-phosphate synthase GAPDH-like
Phosphatidic acid phosphatase type 2/haloperoxidase
Chitin-binding type-4 domain-containing protein
Alpha-D-phosphohexomutase alpha/beta/alpha
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Plays an important role in substrate specificity
ABC transporter substrate-binding protein PnrA-like
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Glycerophosphoryl diester phosphodiesterase membrane
Penicillin-binding protein transpeptidase
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
6-phosphogluconate dehydrogenase NADP-binding
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
non-reducing end alpha-L-arabinofuranosidase
Polymerase/histidinol phosphatase N-terminal
CD-NTase associated protein 4-like DNA endonuclease
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
DNA primase/polymerase bifunctional N-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
O-(5'-phospho-DNA)-tyrosine intermediate
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Histidine-specific methyltransferase SAM-dependent
Glutathionylspermidine synthase pre-ATP-grasp-like
Gram-positive cocci surface proteins LPxTG
Large ribosomal subunit protein uL2 C-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Glycosyltransferase subfamily 4-like N-terminal
Thiamine pyrophosphate enzyme TPP-binding
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Sporulation transcription regulator WhiA N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Shikimate dehydrogenase substrate binding N-terminal
Tryptophan synthase beta chain-like PALP
Cation-transporting P-type ATPase C-terminal
PhoD-like phosphatase metallophosphatase
Tetracyclin repressor-like C-terminal group 31
Alpha-glycerophosphate oxidase C-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
Alpha-N-acetylglucosaminidase C-terminal
Alpha-N-acetylglucosaminidase N-terminal
Alpha-N-acetylglucosaminidase tim-barrel
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Schiff-base intermediate with D-ribose 5-phosphate
Important for substrate specificity; cannot use PPi as phosphoryl donor
Phosphomannose isomerase type I catalytic
Exonuclease VII large subunit C-terminal
Cell envelope-related transcriptional attenuator
Methionyl-tRNA synthetase anticodon-binding
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Important for beta-aspartyl-AMP intermediate formation
NADH-rubredoxin oxidoreductase C-terminal
Lactate utilization protein B C-terminal
Alanyl-transfer RNA synthetases family profile
Could be important to modulate the pK values of the two catalytic cysteine residues
YbaK/aminoacyl-tRNA synthetase-associated
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Gly-cisPro motif, important for rejection of L-amino acids
Glycoside-hydrolase family GH114 TIM-barrel
Acyltransferase MbtK/IucB-like conserved
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Large ribosomal subunit protein uL30-like ferredoxin-like fold
RNA 2-O ribose methyltransferase substrate binding
S-adenosyl-L-homocysteine hydrolase NAD binding
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
DNA-directed DNA polymerase family A palm
Aromatic amino acid beta-eliminating lyase/threonine aldolase
ATP synthase F1 complex delta/epsilon subunit N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Cytochrome bc1 complex cytochrome c subunit
Mandelate racemase/muconate lactonizing enzyme C-terminal
FAD-dependent oxidoreductase 2 FAD binding
Ribose-phosphate pyrophosphokinase N-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Cysteine sulfenic acid (-SOH) intermediate
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Anthranilate synthase component I N-terminal
Transcription regulator AsnC/Lrp ligand binding
Translation elongation factor P/YeiP central
Gp5/Type VI secretion system Vgr protein OB-fold
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
CobB/CobQ-like glutamine amidotransferase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Solute-binding protein family 3/N-terminal
ABC-type glycine betaine transport system substrate-binding
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Gram-positive cocci surface proteins LPxTG domain-containing protein
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
PLD phosphodiesterase domain-containing protein
Glucosamine/galactosamine-6-phosphate isomerase
Peptide methionine sulphoxide reductase MsrA
Membrane insertase YidC/Oxa/ALB C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Cytochrome oxidase subunit II copper A binding
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Glycoside hydrolase family 31 N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Glycine cleavage T-protein C-terminal barrel
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
Resolvase/invertase-type recombinase catalytic
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
DnaJ homologue subfamily C member 28 conserved
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Phosphocysteine intermediate; for EIIB activity
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Peptidoglycan recognition protein family
Threonine/serine exporter-like N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Peptidase M1 membrane alanine aminopeptidase
Nitrite/Sulfite reductase ferredoxin-like
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Small ribosomal subunit protein uS4 N-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
4'-phosphopantetheinyl transferase N-terminal
Damage-control phosphatase ARMT1-like metal-binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Glycosyl transferase family 3 N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Probable transposase IS891/IS1136/IS1341
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Interaction with polymerase core subunit RpoC
Glycoside hydrolase family 42 N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Prokaryotic-type class I peptide chain release factors
Phosphatidylglycerol lysyltransferase C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Heat-inducible transcription repressor HrcA C-terminal
Transition state stabilizer; via amide nitrogen
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Carbamoyl-phosphate synthase small subunit N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Putative glycogen debranching enzyme N-terminal
Beta/gamma crystallin 'Greek key' domain-containing protein
Probable subtilase-type protease inhibitor
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Arabinogalactan endo-beta-1,4-galactanase
vWA-MoxR associated protein middle region 2
Pyruvate dehydrogenase E1 component middle
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
DNA replication/recombination mediator RecO N-terminal
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Bacterial type II secretion system protein E
Reversibly protonated during proton transport
Type II restriction enzyme and methyltransferase RM.Eco57I-like
Pyrimidine nucleoside phosphorylase C-terminal
Involved in ionization of N3 of dUMP, leading to its activation
Prepilin type IV endopeptidase peptidase
Type ISP restriction-modification enzyme LLaBIII C-terminal specificity
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
N,N-dimethylformamidase beta subunit-like C-terminal
Cytochrome b/b6 N-terminal region profile
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Large ribosomal subunit protein uL15/eL18
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Adaptive response protein AidB N-terminal
Microcin J25-processing protein McjB C-terminal
Lysyl-tRNA synthetase N-terminal transmembrane region
Heme-copper oxidase subunit III family profile
Resuscitation-promoting factor core lysozyme-like
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Tat pathway signal sequence domain protein
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Essential for prephenate dehydratase activity
Beta-xylosidase C-terminal Concanavalin A-like
Helix-hairpin-helix DNA-binding motif class 1
MmyB-like transcription regulator ligand binding
N-acetylneuraminic acid synthase N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Beta-hexosaminidase bacterial type N-terminal
Electron transfer via tryptophanyl radical
6-phosphogluconate dehydrogenase C-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Schiff-base intermediate with substrate; via topaquinone
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
Involved in allosteric activation by GTP
Positions MEP for the nucleophilic attack
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Type I restriction modification DNA specificity
NADH:ubiquinone oxidoreductase 30kDa subunit
Peptidoglycan binding-like domain-containing protein
Pyruvate phosphate dikinase AMP/ATP-binding
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Styrene monooxygenase StyA putative substrate binding
Proton acceptor; for glutaminase activity
Sigma 54 modulation/S30EA ribosomal protein C-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Cytochrome C biogenesis protein transmembrane
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Glycosyl hydrolases family 2 sugar binding
Peptidase C39-like domain-containing protein
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Pseudouridine synthase I TruA alpha/beta
Protein O-mannosyl-transferase C-terminal four TM
Glyoxalase/fosfomycin resistance/dioxygenase
Putative Flp pilus-assembly TadG-like N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central