Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Phosphocysteine intermediate; for EIIB activity
Resolvase/invertase-type recombinase catalytic
Inner membrane protein YgaP-like transmembrane
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Polymerase/histidinol phosphatase N-terminal
Urease accessory protein UreH-like transmembrane
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
DNA replication/recombination mediator RecO N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Major facilitator superfamily (MFS) profile
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Alpha-glycerophosphate oxidase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transposase IS204/IS1001/IS1096/IS1165 helix-turn-helix
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
Release factor glutamine methyltransferase N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Alpha-D-phosphohexomutase alpha/beta/alpha
NADH:ubiquinone oxidoreductase 30kDa subunit
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Helix-hairpin-helix DNA-binding motif class 1
CRISPR system ring nuclease SSO1393-like
Aminoacyl-transfer RNA synthetases class-II family profile
Prokaryotic-type class I peptide chain release factors
Replication-associated protein G2P N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Acyl-CoA dehydrogenase/oxidase C-terminal
Adaptive response protein AidB N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Lantibiotic immunity protein Spa1 C-terminal
Type II restriction enzyme and methyltransferase RM.Eco57I-like
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Schiff-base intermediate with D-ribose 5-phosphate
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Exonuclease VII large subunit C-terminal
SUF system FeS cluster assembly SufBD N-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Quinohemoprotein amine dehydrogenase gamma subunit structural
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Transcriptional regulator LacI/GalR-like sensor
Acyl-CoA dehydrogenase/oxidase N-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Sporulation stage IV protein A C-terminal
Phosphoribosylformylglycinamidine synthase linker
Glucosamine/galactosamine-6-phosphate isomerase
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Involved in allosteric activation by GTP
YbaK/aminoacyl-tRNA synthetase-associated
Reversibly protonated during proton transport
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Diacylglycerol glucosyltransferase N-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Menaquinone biosynthesis protein MenD middle
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Membrane insertase YidC/Oxa/ALB C-terminal
Cell envelope-related transcriptional attenuator
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Sortilin N-terminal domain-containing protein
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Large ribosomal subunit protein uL2 C-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Plays an important role in substrate specificity
Carbamoyl-phosphate synthase small subunit N-terminal
Bacterial type II secretion system protein E
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Schiff-base intermediate with acetaldehyde
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Important for interaction with partner proteins
Transposase IS116/IS110/IS902 C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
CobB/CobQ-like glutamine amidotransferase
O-(3'-phospho-DNA)-tyrosine intermediate
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Polysaccharide biosynthesis protein CapD-like
Gamma-glutamylcyclotransferase AIG2-like
Tryptophan synthase beta chain-like PALP
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Alanyl-transfer RNA synthetases family profile
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Penicillin-binding protein transpeptidase
Superoxide dismutase copper/zinc binding
Phosphotransferase system enzyme I N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
NIF system FeS cluster assembly NifU C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Peptide methionine sulphoxide reductase MsrA
Sporulation initiation phosphotransferase B C-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
DnaJ homologue subfamily C member 28 conserved
Positions MEP for the nucleophilic attack
6-phosphogluconate dehydrogenase C-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Flagellar assembly protein FliH/Type III secretion system HrpE
Large ribosomal subunit protein uL6 alpha-beta
Type III restriction enzyme C-terminal endonuclease
Gly-cisPro motif, important for rejection of L-amino acids
Phosphopantothenoylcysteine decarboxylase
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Putative glycogen debranching enzyme N-terminal
Sporulation transcription regulator WhiA N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
RNA 2-O ribose methyltransferase substrate binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Anthranilate synthase component I N-terminal
Sodium/calcium exchanger membrane region
Small ribosomal subunit protein uS4 N-terminal
Prepilin type IV endopeptidase peptidase
Could be important to modulate the pK values of the two catalytic cysteine residues
Cytochrome b561 bacterial/Ni-hydrogenase
RNA polymerase sigma factor 70 region 4 type 2
Cell wall-active antibiotics response LiaF-like C-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Single-stranded-DNA-specific exonuclease RecJ C-terminal
6-hydroxymethylpterin diphosphokinase MptE-like
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Translation elongation factor P/YeiP central
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
RNA binding; important for wobble base 34 recognition
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Increases nucleophilicity of active site Cys
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Protein-PII uridylyltransferase N-terminal
Interaction with polymerase core subunit RpoC
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Large ribosomal subunit protein uL30-like ferredoxin-like fold
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Large ribosomal subunit protein uL15/eL18
RDXXRA motif of the pArg binding pocket involved in allosteric regulation
Important for beta-aspartyl-AMP intermediate formation
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding