Reversibly protonated during proton transport
Aminoacyl-transfer RNA synthetases class-II family profile
Alanyl-transfer RNA synthetases family profile
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Large ribosomal subunit protein uL2 C-terminal
Pseudouridine synthase I TruA alpha/beta
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
X-Prolyl dipeptidyl aminopeptidase PepX N-terminal
Cell envelope-related transcriptional attenuator
Could be important to modulate the pK values of the two catalytic cysteine residues
Ribosomal RNA small subunit methyltransferase E methyltransferase
Polysaccharide biosynthesis protein C-terminal
Cation-transporting P-type ATPase N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
Alpha-glycerophosphate oxidase C-terminal
DNA mismatch repair proteins mutS family
RNA 2-O ribose methyltransferase substrate binding
O-(5'-phospho-DNA)-tyrosine intermediate
6-phosphogluconate dehydrogenase C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Regulator of chromosome segregation-like C-terminal
HicB-like antitoxin of toxin-antitoxin system
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Important for beta-aspartyl-AMP intermediate formation
Polysaccharide chain length determinant N-terminal
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Polymerase/histidinol phosphatase N-terminal
Major facilitator superfamily (MFS) profile
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
RNA polymerase sigma factor 70 region 4 type 2
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Glucosamine/galactosamine-6-phosphate isomerase
Sporulation transcription regulator WhiA N-terminal
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Phosphomannose isomerase type I catalytic
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Release factor glutamine methyltransferase N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Exonuclease VII large subunit C-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
DNA replication/recombination mediator RecO N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
RNA binding; important for wobble base 34 recognition
Translation elongation factor P/YeiP central
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
Abortive infection protein-like C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Glycosyltransferase subfamily 4-like N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Pyrimidine nucleoside phosphorylase C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Chromosomal replication initiator DnaA C-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Type VII secretion system protein EssD-like
Important for interaction with partner proteins
Helix-hairpin-helix DNA-binding motif class 1
Peptidase M1 membrane alanine aminopeptidase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Large ribosomal subunit protein uL6 alpha-beta
Interaction with polymerase core subunit RpoC
Helix-turn-helix conjugative transposon-like
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Important for autoinhibition of adenylyltransferase activity
Prokaryotic-type class I peptide chain release factors
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Penicillin-binding protein transpeptidase
YbaK/aminoacyl-tRNA synthetase-associated
Carbamoyl-phosphate synthase small subunit N-terminal
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Schiff-base intermediate with acetaldehyde
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Small ribosomal subunit protein uS4 N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Cell wall-active antibiotics response LiaF-like C-terminal
Replication initiation protein-like C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
Gram-positive cocci surface proteins LPxTG
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
O-(3'-phospho-DNA)-tyrosine intermediate
Ribosomal RNA adenine methylase transferase N-terminal
Single-stranded-DNA-specific exonuclease RecJ C-terminal
Cell division protein FtsQ/DivIB C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
DNA-directed DNA polymerase family A palm
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Conserved virulence factor B-like winged helix
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Resolvase/invertase-type recombinase catalytic
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Peptide methionine sulphoxide reductase MsrA
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Sigma 54 modulation/S30EA ribosomal protein C-terminal
CobB/CobQ-like glutamine amidotransferase
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Rolling Circle replication initiation protein N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
ATP synthase F1 complex delta/epsilon subunit N-terminal
Thiamin pyrophosphokinase thiamin-binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Phosphotransferase system enzyme I N-terminal
Involved in allosteric activation by GTP
tRNA pseudouridylate synthase B C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Threonine/serine exporter-like N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Bacterial type II secretion system protein E
Putative host cell surface-exposed lipoprotein Ltp-like HTH region
Large ribosomal subunit protein uL15/eL18
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Plays an important role in substrate specificity
Thymidylate synthase/dCMP hydroxymethylase
Phosphotransferase system EIIB component type 2/3
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding