Phosphatidate phosphatase APP1 catalytic
SGNH hydrolase-type esterase domain-containing protein
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Arabinofuranosyltransferase AftA C-terminal
Arabinofuranosyltransferase AftA N-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Tryptophan synthase beta chain-like PALP
Pyrimidine nucleoside phosphorylase C-terminal
Major facilitator superfamily (MFS) profile
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
PhoD-like phosphatase metallophosphatase
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
RNA binding; important for wobble base 34 recognition
Transcription regulator AsnC/Lrp ligand binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
5-glutamyl coenzyme A thioester intermediate
Prokaryotic-type class I peptide chain release factors
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Nitrite/Sulfite reductase ferredoxin-like
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
RNA 2-O ribose methyltransferase substrate binding
O-(3'-phospho-DNA)-tyrosine intermediate
Aminoacyl-transfer RNA synthetases class-II family profile
ATP synthase F1 complex delta/epsilon subunit N-terminal
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Phosphoribosylformylglycinamidine synthase linker
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Schiff-base intermediate with dihydroxyacetone-P
Small ribosomal subunit protein uS4 N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Pyruvate dehydrogenase E1 component middle
Alanyl-transfer RNA synthetases family profile
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Peptidoglycan recognition protein family
Myo-inositol-1-phosphate synthase GAPDH-like
Resuscitation-promoting factor core lysozyme-like
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glucosamine/galactosamine-6-phosphate isomerase
Glycosyltransferase subfamily 4-like N-terminal
Cysteine sulfenic acid (-SOH) intermediate
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Inosine/uridine-preferring nucleoside hydrolase
Essential for prephenate dehydratase activity
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Thymidylate synthase/dCMP hydroxymethylase
NIF system FeS cluster assembly NifU N-terminal
Cytochrome b/b6 N-terminal region profile
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Penicillin-binding protein transpeptidase
FAD-dependent oxidoreductase 2 FAD binding
N6 adenine-specific DNA methyltransferase N-terminal
ATP-dependent DNA helicase RecG C-terminal
Plays an important role in substrate specificity
Phosphatidic acid phosphatase type 2/haloperoxidase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Polysaccharide biosynthesis protein CapD-like
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Prepilin type IV endopeptidase peptidase
YbaK/aminoacyl-tRNA synthetase-associated
Type I restriction modification DNA specificity
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Large ribosomal subunit protein uL6 alpha-beta
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Cell wall-active antibiotics response LiaF-like C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Peptidase M1 membrane alanine aminopeptidase
Heat-inducible transcription repressor HrcA C-terminal
Anthranilate synthase component I N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
6-phosphogluconate dehydrogenase C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Glycine cleavage T-protein C-terminal barrel
S-adenosyl-L-homocysteine hydrolase NAD binding
SUF system FeS cluster assembly SufBD N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Large ribosomal subunit protein uL15/eL18
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
DNA replication/recombination mediator RecO N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Involved in ionization of N3 of dUMP, leading to its activation
Bacterial bifunctional deaminase-reductase C-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
O-(5'-phospho-DNA)-tyrosine intermediate
Cytochrome oxidase subunit II copper A binding
Sporulation transcription regulator WhiA N-terminal
Gram-positive pilin subunit D1 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Exonuclease VII large subunit C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Gly-cisPro motif, important for rejection of L-amino acids
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Polymerase/histidinol phosphatase N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
DNA-directed DNA polymerase family A palm
Reversibly protonated during proton transport
Alpha-D-phosphohexomutase alpha/beta/alpha
Large ribosomal subunit protein uL2 C-terminal
Schiff-base intermediate with acetaldehyde
Interaction with polymerase core subunit RpoC
Glucose-methanol-choline oxidoreductase N-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Shikimate dehydrogenase substrate binding N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Aminoacyl-tRNA synthetase class I anticodon-binding
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Glyoxalase/fosfomycin resistance/dioxygenase
Alpha-glycerophosphate oxidase C-terminal
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
4'-phosphopantetheinyl transferase N-terminal
Important for beta-aspartyl-AMP intermediate formation
Glucose-methanol-choline oxidoreductase C-terminal
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Phosphocysteine intermediate; for EIIB activity
Threonine/serine exporter-like N-terminal
Phosphotransferase system enzyme I N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
Peptide methionine sulphoxide reductase MsrA
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Endoribonuclease L-PSP/chorismate mutase-like
Translation elongation factor P/YeiP central
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole