Anthranilate synthase component I N-terminal
Exonuclease VII large subunit C-terminal
Major facilitator superfamily (MFS) profile
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Putative oxidoreductase/dehydrogenase Rossmann-like
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Schiff-base intermediate with substrate; via pyruvic acid
NIF system FeS cluster assembly NifU N-terminal
Thiolase-like protein type 1 additional C-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Prokaryotic-type class I peptide chain release factors
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Carbamoyl-phosphate synthase small subunit N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Phosphocysteine intermediate; for EIIB activity
Translation elongation factor P/YeiP central
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Alanyl-transfer RNA synthetases family profile
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glucosamine/galactosamine-6-phosphate isomerase
Cysteine sulfenic acid (-SOH) intermediate
Type I restriction enzyme R protein N-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-120)
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
ATP-dependent DNA helicase RecG C-terminal
Solute-binding protein family 3/N-terminal
Phosphotransferase system enzyme I N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
SUF system FeS cluster assembly SufBD N-terminal
Methionyl-tRNA synthetase anticodon-binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Tryptophan synthase beta chain-like PALP
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
RNA binding; important for wobble base 34 recognition
Interaction with polymerase core subunit RpoC
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Lactate utilization protein B C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Na+/H+ antiporter MnhB subunit-related protein
Bacterial bifunctional deaminase-reductase C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Schiff-base intermediate with substrate; via topaquinone
Calcineurin-like phosphoesterase C-terminal
Calcineurin-like phosphoesterase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Mandelate racemase/muconate lactonizing enzyme C-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Endoribonuclease L-PSP/chorismate mutase-like
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Aminoacyl-transfer RNA synthetases class-II family profile
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
RNA polymerase sigma factor 70 region 4 type 2
Polymerase/histidinol phosphatase N-terminal
Peptide methionine sulphoxide reductase MsrA
Threonine/serine exporter-like N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
O-(3'-phospho-DNA)-tyrosine intermediate
Glycosyltransferase subfamily 4-like N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Alpha-D-phosphohexomutase alpha/beta/alpha
Phosphoribosylformylglycinamidine synthase linker
RNA 2-O ribose methyltransferase substrate binding
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Sodium/calcium exchanger membrane region
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Homogentisate 1,2-dioxygenase C-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Reversibly protonated during proton transport
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Helix-hairpin-helix DNA-binding motif class 1
Proton acceptor; for glutaminase activity
Peptidase S9 prolyl oligopeptidase catalytic
Small ribosomal subunit protein uS4 N-terminal
Adaptive response protein AidB N-terminal
Peptidase M1 membrane alanine aminopeptidase
Ribosomal RNA small subunit methyltransferase E methyltransferase
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
5-glutamyl coenzyme A thioester intermediate
Could be important to modulate the pK values of the two catalytic cysteine residues
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Pyruvate dehydrogenase E1 component middle
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Penicillin-binding protein transpeptidase
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Important for beta-aspartyl-AMP intermediate formation
Schiff-base intermediate with D-ribose 5-phosphate
Cell wall-active antibiotics response LiaF-like C-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
6-phosphogluconate dehydrogenase C-terminal
Cytochrome b/b6 N-terminal region profile
Pyridoxamine 5'-phosphate oxidase putative
CobB/CobQ-like glutamine amidotransferase
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Large ribosomal subunit protein uL15/eL18
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Transcription regulator AsnC/Lrp ligand binding
S-adenosyl-L-homocysteine hydrolase NAD binding
TRAP C4-dicarboxylate transport system permease DctM subunit
Thiostrepton-resistance methylase N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Protein O-mannosyl-transferase C-terminal four TM
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
ssDNA thymidine ADP-ribosyltransferase DarT
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Fe/B12 periplasmic-binding domain-containing protein
O-(5'-phospho-DNA)-tyrosine intermediate
N6 adenine-specific DNA methyltransferase N-terminal
Large ribosomal subunit protein uL2 C-terminal
Pseudouridine synthase I TruA alpha/beta
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Important for substrate specificity; cannot use PPi as phosphoryl donor
Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase
Myo-inositol-1-phosphate synthase GAPDH-like
Resuscitation-promoting factor Rpf1 C-terminal
Resuscitation-promoting factor core lysozyme-like
Pyruvate phosphate dikinase AMP/ATP-binding
4'-phosphopantetheinyl transferase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
DNA replication/recombination mediator RecO N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Glycine cleavage T-protein C-terminal barrel
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Ribosome maturation factor RimP N-terminal
Essential for prephenate dehydratase activity
Shikimate dehydrogenase substrate binding N-terminal
Cation-transporting P-type ATPase N-terminal
Thymidylate synthase/dCMP hydroxymethylase
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
DNA-directed DNA polymerase family A palm
Involved in ionization of N3 of dUMP, leading to its activation
Acyltransferase MbtK/IucB-like conserved
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Plays an important role in substrate specificity
Alpha-glycerophosphate oxidase C-terminal
Peptidase metallopeptidase domain-containing protein
Cytochrome C biogenesis protein transmembrane
Protocatechuate 3,4-dioxygenase beta subunit N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Schiff-base intermediate with acetaldehyde