Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Major facilitator superfamily (MFS) profile
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Resolvase/invertase-type recombinase catalytic
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Anthranilate synthase component I N-terminal
Release factor glutamine methyltransferase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Important for beta-aspartyl-AMP intermediate formation
Proline utilization A proline dehydrogenase N-terminal
Involved in allosteric activation by GTP
Mandelate racemase/muconate lactonizing enzyme C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Heme-copper oxidase subunit III family profile
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Cysteine sulfenic acid (-SOH) intermediate
Bacterial type II secretion system protein E
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
TonB-dependent receptor-like beta-barrel
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Interaction with polymerase core subunit RpoC
Solute-binding protein family 3/N-terminal
Glycosyl transferase family 3 N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
RND efflux pump membrane fusion protein barrel-sandwich
Phosphoethanolamine transferase N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Contractile injection system tube protein N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Phosphocysteine intermediate; for EIIB activity
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Major facilitator superfamily associated
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Penicillin-binding protein transpeptidase
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Type III restriction enzyme C-terminal endonuclease
N6 adenine-specific DNA methyltransferase N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Aminoacyl-tRNA synthetase class I anticodon-binding
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Regulator of nucleoside diphosphate kinase N-terminal
Pyruvate dehydrogenase E1 component middle
6-phosphogluconate dehydrogenase NADP-binding
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Could be important to modulate the pK values of the two catalytic cysteine residues
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Pyrroline-5-carboxylate reductase catalytic N-terminal
Interacts with tRNA; defines subfamily-specific binding signature
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Erythronate-4-phosphate dehydrogenase dimerisation
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
DnaJ homologue subfamily C member 28 conserved
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
RNA polymerase sigma factor 70 region 4 type 2
Polymerase/histidinol phosphatase N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Membrane fusion protein biotin-lipoyl like
UDP N-acetylglucosamine O-acyltransferase C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Transposase IS116/IS110/IS902 C-terminal
Outer membrane protein assembly factor BamA
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Reversibly protonated during proton transport
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Essential for prephenate dehydratase activity
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Type I restriction modification DNA specificity
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Thymidylate synthase/dCMP hydroxymethylase
Nucleoside-specific channel-forming protein Tsx
Important for interaction with partner proteins
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Restriction system protein Mrr-like N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
Large ribosomal subunit protein uL6 alpha-beta
Quercetin 2,3-dioxygenase C-terminal cupin
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Inosine/uridine-preferring nucleoside hydrolase
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Tryptophan synthase beta chain-like PALP
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Prokaryotic-type class I peptide chain release factors
Alanyl-transfer RNA synthetases family profile
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Important for substrate binding and specificity
Translation elongation factor P/YeiP central
Type II secretion system protein GspG C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Chromosomal replication initiator protein DnaA
Pseudouridine synthase I TruA alpha/beta
DNA polymerase III delta subunit C-terminal
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase N-terminal
Ionotropic glutamate receptor C-terminal
Phosphoadenosine phosphosulphate reductase
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Flagellar motor switch protein FliN N-terminal
Flagellar motor switch protein FliN-like C-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Sugar fermentation stimulation protein C-terminal
Sodium/calcium exchanger membrane region
Large ribosomal subunit protein uL15/eL18
Helix-hairpin-helix DNA-binding motif class 1
Aspartate/homoserine dehydrogenase NAD-binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
ATP-dependent DNA helicase RecG C-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Appears to be important in orienting the phosphate for catalysis
Tetrahydrodipicolinate-N-succinyltransferase chain A
O-(phosphoribosyl dephospho-coenzyme A)serine
Hypersensitivity response secretion-like HrpJ
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Could play a key role in the communication between the regulatory and the substrate sites
Lysidine-tRNA(Ile) synthetase C-terminal
Required for dimer formation and molybdate binding
Gp5/Type VI secretion system Vgr protein OB-fold
Mechanosensitive ion channel inner membrane
Tat pathway signal sequence domain protein
Exonuclease VII large subunit C-terminal
Glycoside hydrolase family 42 N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
D-galactose/methyl-galactoside binding periplasmic protein MglB
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Transglycosylase PBP1b N-terminal transmembrane
Plays an important role in substrate specificity
Cob(I)alamin adenosyltransferase N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Polysaccharide biosynthesis protein CapD-like
Large ribosomal subunit protein bL25 L25
NIF system FeS cluster assembly NifU C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Penicillin-insensitive murein endopeptidase
Positions MEP for the nucleophilic attack
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
Type 2A encapsulin shell protein SrpI-like
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Arginine decarboxylase C-terminal helical
Periplasmic protein related to spheroblast formation
Ribosomal RNA adenine methylase transferase N-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Type II secretion system protein GspI C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Peptidase S9 prolyl oligopeptidase catalytic
O-(5'-phospho-DNA)-tyrosine intermediate
Large ribosomal subunit protein uL2 C-terminal
Tellurite resistance methyltransferase TehB-like
DNA polymerase III subunit delta C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Electron transfer via tryptophanyl radical
DNA replication/recombination mediator RecO N-terminal
Outer membrane protein assembly factor BamB
Outer membrane protein assembly factor BamD
Non-canonical purine NTP phosphatase/PRRC1
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Alpha-glycerophosphate oxidase C-terminal
Carbapenam-3-carboxylate synthase N-terminal
Phosphotransferase system enzyme I N-terminal
RNA binding; important for wobble base 34 recognition
Nucleophile; cysteine thiosulfonate intermediate
Glycoside hydrolase family 31 N-terminal
Type III secretion system flagellar brake protein YcgR PilZN
Small ribosomal subunit protein uS4 N-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
NIF system FeS cluster assembly NifU N-terminal
Penicillin-binding protein activator LpoB
Pyrroline-5-carboxylate reductase dimerisation
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Threonine/serine exporter-like N-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Glycine cleavage T-protein C-terminal barrel
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
RNA methyltransferase SpoU/TrmH type C-terminal
Flagella basal body P-ring formation protein FlgA
Type II secretion system protein GspC N-terminal
RNA 2-O ribose methyltransferase substrate binding
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Pyruvate phosphate dikinase AMP/ATP-binding