Important for beta-aspartyl-AMP intermediate formation
Bacterial type II secretion system protein E
Type II secretion system protein GspE N-terminal
ATP-grasp fold succinyl-CoA synthetase-type
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Endonuclease/exonuclease/phosphatase domain-containing protein
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Transposase IS116/IS110/IS902 C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
PEP-CTERM protein-sorting domain-containing protein
RNA polymerase sigma factor 70 region 4 type 2
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Membrane fusion protein biotin-lipoyl like
Translation elongation factor P/YeiP central
Nitrite/Sulfite reductase ferredoxin-like
Resolvase/invertase-type recombinase catalytic
O-(5'-phospho-DNA)-tyrosine intermediate
Inner membrane protein YgaP-like transmembrane
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Aminoacyl-transfer RNA synthetases class-II family profile
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Gfo/Idh/MocA-like oxidoreductase bacterial type C-terminal
Major facilitator superfamily (MFS) profile
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Putative regulatory protein FmdB Zinc ribbon
Anaphase-promoting complex subunit 4-like WD40
LamG-like jellyroll fold domain-containing protein
NfeD-like C-terminal domain-containing protein
Large ribosomal subunit protein uL6 alpha-beta
Carboxypeptidase regulatory-like domain-containing protein
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Activator of Hsp90 ATPase homologue 1-like C-terminal
Important for interaction with partner proteins
Peptide methionine sulfoxide reductase MsrA
Peptide methionine sulphoxide reductase MsrA
PsbP C-terminal domain-containing protein
Terminase large subunit-like endonuclease
RND efflux pump membrane fusion protein barrel-sandwich
NIF system FeS cluster assembly NifU C-terminal
3-keto-disaccharide hydrolase domain-containing protein
Phosphotransferase system enzyme I N-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal domain-containing protein
Small ribosomal subunit protein uS4 N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Neutral/alkaline non-lysosomal ceramidase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Shikimate dehydrogenase substrate binding N-terminal
N-sulphoglucosamine sulphohydrolase C-terminal
Nickel uptake substrate-specific transmembrane region
Tryptophan synthase beta chain-like PALP
SGNH hydrolase-type esterase domain-containing protein
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Could play a key role in the communication between the regulatory and the substrate sites
Polysaccharide biosynthesis protein C-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Quercetin 2,3-dioxygenase C-terminal cupin
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Calcium-dependent phosphoinositide phospholipase C
Cytochrome b/b6 N-terminal region profile
Opioid growth factor receptor (OGFr) conserved
Heme-copper oxidase subunit III family profile
Prokaryotic-type class I peptide chain release factors
Molybdopterin cofactor biosynthesis C (MoaC)
Soluble ligand binding domain-containing protein
N,N-dimethylformamidase beta subunit-like C-terminal
Positions MEP for the nucleophilic attack
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Survival protein SurE-like phosphatase/nucleotidase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
DNA mismatch repair proteins mutS family
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Pyruvate phosphate dikinase AMP/ATP-binding
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Dienelactone hydrolase domain-containing protein
Lysidine-tRNA(Ile) synthetase C-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Exonuclease VII large subunit C-terminal
Large ribosomal subunit protein uL15/eL18
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Polymerase/histidinol phosphatase N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding
Alpha-D-phosphohexomutase alpha/beta/alpha
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr C-terminal
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Schiff-base intermediate with acetaldehyde
Solute-binding protein family 5 domain-containing protein
Glucosamine/galactosamine-6-phosphate isomerase
DNA-directed DNA polymerase family A palm
NADH-rubredoxin oxidoreductase C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Oxidoreductase molybdopterin-binding domain-containing protein
Acetylserotonin O-methyltransferase dimerisation
Phosphomannose isomerase type I catalytic
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
SUF system FeS cluster assembly SufBD N-terminal
Prepilin type IV endopeptidase peptidase
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 C-terminal domain-containing protein
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
CD-NTase-associated protein 12/Pycsar effector protein TIR
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Could be important to modulate the pK values of the two catalytic cysteine residues
Gamma-butyrobetaine hydroxylase-like N-terminal
Trigger factor ribosome-binding bacterial
Reversibly protonated during proton transport
Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein
O-(3'-phospho-DNA)-tyrosine intermediate
Schiff-base intermediate with substrate; via pyruvic acid
Methionyl-tRNA synthetase anticodon-binding
ABC-type uncharacterised transport system
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Essential for prephenate dehydratase activity
Methanolan biosynthesis EpsI domain-containing protein
Cytochrome b/b6 C-terminal region profile
Anthranilate synthase component I N-terminal
Proton acceptor; for glutaminase activity
Sodium/calcium exchanger membrane region
Glucose-methanol-choline oxidoreductase N-terminal
Glycoside hydrolase family 57 N-terminal
Large ribosomal subunit protein uL2 C-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Beta-lactamase hydrolase-like protein phosphatase-like
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Glycoside hydrolase family 38 N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Cytochrome b561 bacterial/Ni-hydrogenase
Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein
Cytochrome C Planctomycete-type domain-containing protein
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Glycine cleavage T-protein C-terminal barrel
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Peptidase C45 hydrolase domain-containing protein
Ribose-phosphate pyrophosphokinase N-terminal
Schiff-base intermediate with substrate; via topaquinone
YbaK/aminoacyl-tRNA synthetase-associated
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Endoribonuclease L-PSP/chorismate mutase-like
Alanyl-transfer RNA synthetases family profile
Carbamoyl-phosphate synthase small subunit N-terminal
CobB/CobQ-like glutamine amidotransferase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Putative glycogen debranching enzyme N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
MotA/TolQ/ExbB proton channel domain-containing protein
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
6-phosphogluconate dehydrogenase C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Transposase IS204/IS1001/IS1096/IS1165 DDE
Outer membrane lipoprotein-sorting protein
Serine aminopeptidase S33 domain-containing protein
Secretin/TonB short N-terminal domain-containing protein
PhoD-like phosphatase metallophosphatase
DNA helicase Holliday junction RuvA type
DNA replication/recombination mediator RecO N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
General stress protein FMN-binding split barrel
3-beta hydroxysteroid dehydrogenase/isomerase
Plays an important role in substrate specificity
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Transglutaminase-like domain-containing protein
Lactate utilization protein B C-terminal
Glycosyl transferase family 3 N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Xylose isomerase-like TIM barrel domain-containing protein
Scyllo-inositol 2-dehydrogenase (NAD(+))
Methylene-tetrahydromethanopterin dehydrogenase N-terminal
Carboxymuconolactone decarboxylase-like domain-containing protein
Flagellar motor switch protein FliN-like C-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Gp5/Type VI secretion system Vgr protein OB-fold
Myo-inositol-1-phosphate synthase GAPDH-like
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Glutamate synthase alpha subunit C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
TRASH transcription regulator C-terminal archaeal
TRASH transcription regulator C-terminal archaeal domain-containing protein
Peptidase metallopeptidase domain-containing protein
Alpha-amylase/4-alpha-glucanotransferase C-terminal
Alpha-amylase/4-alpha-glucanotransferase central
S-adenosylmethionine-dependent methyltransferase
Phosphoribosylformylglycinamidine synthase linker
Transcription factor NikR nickel binding C-terminal
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
K(+)-insensitive pyrophosphate-energized proton pump
Periplasmic copper-binding protein NosD beta helix
Periplasmic copper-binding protein NosD beta helix domain-containing protein
Thymidylate synthase/dCMP hydroxymethylase
Formamidopyrimidine-DNA glycosylase catalytic
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
PhoPQ-activated pathogenicity-related protein
1,4-alpha-glucan branching enzyme C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal