Required for zinc-mediated homotetramerization and catalytic activity
Beta-lactamase hydrolase-like protein phosphatase-like
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
RND efflux pump membrane fusion protein barrel-sandwich
Histidine phosphotransferase ChpT C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Methionyl-tRNA synthetase anticodon-binding
O-(3'-phospho-DNA)-tyrosine intermediate
RNA polymerase sigma factor 70 region 4 type 2
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Large ribosomal subunit protein uL2 C-terminal
Important for beta-aspartyl-AMP intermediate formation
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Phage terminase large subunit GpA ATPase
Terminase large subunit GpA endonuclease
Major facilitator superfamily (MFS) profile
PQQ-dependent catabolism-associated beta-propeller protein
Tetrahydrodipicolinate-N-succinyltransferase chain A
Choloylglycine hydrolase/NAAA C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Gamma-glutamylcyclotransferase AIG2-like
Proton acceptor; for glutaminase activity
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Cytochrome C biogenesis protein transmembrane
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Prepilin type IV endopeptidase peptidase
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Peptidase S9 prolyl oligopeptidase catalytic
Glycosyltransferase subfamily 4-like N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Nitrite/Sulfite reductase ferredoxin-like
O-(5'-phospho-DNA)-tyrosine intermediate
3-keto-disaccharide hydrolase domain-containing protein
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Phosphoadenosine phosphosulphate reductase
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
ATP synthase F1 complex delta/epsilon subunit N-terminal
Glycine zipper domain-containing protein
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Solute-binding protein family 3/N-terminal
Sodium/calcium exchanger membrane region
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Glycine cleavage T-protein C-terminal barrel
Plays an important role in substrate specificity
Pseudouridine synthase I TruA alpha/beta
Glutamate synthase alpha subunit C-terminal
PHA accumulation regulator DNA-binding N-terminal
N-end rule aminoacyl transferase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Resolvase/invertase-type recombinase catalytic
Flavocytochrome c sulphide dehydrogenase flavin-binding
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Cob(I)alamin adenosyltransferase N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
YbaK/aminoacyl-tRNA synthetase-associated
Autotransporter domain-containing protein
Endoribonuclease L-PSP/chorismate mutase-like
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Aminoacyl-transfer RNA synthetases class-II family profile
Ribose-phosphate pyrophosphokinase N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Polysaccharide chain length determinant N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Electron transfer flavoprotein alpha/beta-subunit N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
tRNA pseudouridylate synthase B C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Interacts with tRNA; defines subfamily-specific binding signature
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
UDP-glucose/GDP-mannose dehydrogenase C-terminal
DNA primase/polymerase bifunctional N-terminal
Pectate lyase superfamily protein domain-containing protein
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Metallo-beta-lactamase domain-containing protein
Prokaryotic-type class I peptide chain release factors
TRAP transporter solute receptor, TAXI family
Gamma-butyrobetaine hydroxylase-like N-terminal
Interaction with polymerase core subunit RpoC
Membrane insertase YidC/Oxa/ALB C-terminal
Leucine-binding protein domain-containing protein
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Glucosamine/galactosamine-6-phosphate isomerase
Activator of Hsp90 ATPase homologue 1-like C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Na+/H+ antiporter MnhB subunit-related protein
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Inner membrane protein YgaP-like transmembrane
Phage terminase large subunit C-terminal
Phage terminase large subunit N-terminal
Superoxide dismutase copper/zinc binding
NADH:ubiquinone oxidoreductase 30kDa subunit
Tryptophan synthase beta chain-like PALP
Glucose-methanol-choline oxidoreductase C-terminal
Peptide methionine sulphoxide reductase MsrA
Penicillin-binding protein transpeptidase
Reversibly protonated during proton transport
Survival protein SurE-like phosphatase/nucleotidase
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Quercetin 2,3-dioxygenase C-terminal cupin
Membrane fusion protein biotin-lipoyl like
Major facilitator superfamily associated
Large ribosomal subunit protein uL15/eL18
Cytochrome b561 bacterial/Ni-hydrogenase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Polysaccharide biosynthesis protein C-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Acetylserotonin O-methyltransferase dimerisation
SUF system FeS cluster assembly SufBD N-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
proton-translocating NAD(P)(+) transhydrogenase
Cysteine sulfenic acid (-SOH) intermediate
Tat pathway signal sequence domain protein
6-phosphogluconate dehydrogenase C-terminal
RNA binding; important for wobble base 34 recognition
Methanol dehydrogenase [cytochrome c] subunit 2
Polysaccharide biosynthesis protein CapD-like
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Phosphatidic acid phosphatase type 2/haloperoxidase
Small ribosomal subunit protein uS4 N-terminal
L,D-transpeptidase catalytic domain-containing protein
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Glucose/Sorbosone dehydrogenase domain-containing protein
Heme-copper oxidase subunit III family profile
Oxidoreductase molybdopterin-binding domain-containing protein
RNA 2-O ribose methyltransferase substrate binding
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Important for interaction with partner proteins
DNA-directed DNA polymerase family A palm
Aconitase A/isopropylmalate dehydratase small subunit swivel
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Sugar fermentation stimulation protein C-terminal
ABC-type transport auxiliary lipoprotein component
UDP N-acetylglucosamine O-acyltransferase C-terminal
Bacteriophage tail tape measure N-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Terminase large subunit gp17-like C-terminal
Translation elongation factor P/YeiP central
Electron transfer via tryptophanyl radical
Involved in allosteric activation by GTP
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-96)
Chromosomal replication initiator DnaA C-terminal
Sodium symporter small subunit predicted
6-hydroxymethylpterin diphosphokinase MptE-like
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Methylene-tetrahydromethanopterin dehydrogenase N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Large ribosomal subunit protein uL6 alpha-beta
Molybdopterin cofactor biosynthesis C (MoaC)
Outer membrane lipoprotein-sorting protein
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
DNA replication/recombination mediator RecO N-terminal
Exonuclease VII large subunit C-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Release factor glutamine methyltransferase N-terminal
Phosphate-specific outer membrane porin OprP
Polymerase/histidinol phosphatase N-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Cytochrome P460 domain-containing protein
Alginate export domain-containing protein