Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
ABC-type glycine betaine transport system substrate-binding
Phosphoethanolamine transferase N-terminal
Sugar fermentation stimulation protein C-terminal
N-end rule aminoacyl transferase C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Heme-copper oxidase subunit III family profile
Pyridoxamine 5'-phosphate oxidase putative
Transcription elongation factor GreA/GreB C-terminal
NIF system FeS cluster assembly NifU N-terminal
Membrane fusion protein biotin-lipoyl like
Flagellar assembly protein FliH/Type III secretion system HrpE
5-glutamyl coenzyme A thioester intermediate
Tryptophan synthase beta chain-like PALP
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Phosphoadenosine phosphosulphate reductase
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Cytochrome c-type biogenesis protein CcmF C-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Solitary outer membrane autotransporter beta-barrel
TRAP C4-dicarboxylate transport system permease DctM subunit
Nitrite/Sulfite reductase ferredoxin-like
Interacts with tRNA; defines subfamily-specific binding signature
Could be important to modulate the pK values of the two catalytic cysteine residues
Branched-chain amino acid ABC transporter substrate-binding protein
Alanyl-transfer RNA synthetases family profile
Major facilitator superfamily (MFS) profile
Integral membrane protein YccS N-terminal
Anthranilate synthase component I N-terminal
Periplasmic nitrate reductase, electron transfer subunit
Interaction with polymerase core subunit RpoC
Aminoacyl-transfer RNA synthetases class-II family profile
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Cytochrome b561 bacterial/Ni-hydrogenase
Transcriptional regulator SgrR N-terminal HTH
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Outer-membrane lipoprotein carrier protein
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
7 transmembrane helices usually fused to an inactive transglutaminase
Inactive transglutaminase fused to 7 transmembrane helices
Polymerase/histidinol phosphatase N-terminal
Dinitrogenase iron-molybdenum cofactor biosynthesis
Aspartate/homoserine dehydrogenase NAD-binding
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
ABC-type transport auxiliary lipoprotein component
ABC-type transport auxiliary lipoprotein component domain-containing protein
Prokaryotic-type class I peptide chain release factors
Poly-beta-hydroxybutyrate polymerase N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Periplasmic binding protein/LacI sugar binding
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
For 3-hydroxyacyl-CoA dehydrogenase activity
Phosphate ABC transporter substrate-binding protein
Glycine zipper domain-containing protein
O-(3'-phospho-DNA)-tyrosine intermediate
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Non-canonical purine NTP phosphatase/PRRC1
Phosphocysteine intermediate; for EIIB activity
Prepilin type IV endopeptidase peptidase
Penicillin-binding protein transpeptidase
Glycosyltransferase subfamily 4-like N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Bacterial type II secretion system protein E
Virulence factor membrane-bound polymerase C-terminal
Outer membrane protein OmpA-like transmembrane
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Lytic transglycosylase superhelical linker
ATP synthase F1 complex delta/epsilon subunit N-terminal
TonB-dependent receptor-like beta-barrel
Outer membrane protein beta-barrel domain-containing protein
Gly-cisPro motif, important for rejection of L-amino acids
Sodium symporter small subunit predicted
DNA mismatch repair proteins mutS family
Gp5/Type VI secretion system Vgr protein OB-fold
DNA polymerase III delta subunit C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Plays an important role in discriminating NADH against NADPH
Large ribosomal subunit protein uL15/eL18
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Mandelate racemase/muconate lactonizing enzyme C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
RNA methyltransferase SpoU/TrmH type C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
RNA binding; important for wobble base 34 recognition
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Choloylglycine hydrolase/NAAA C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Large ribosomal subunit protein uL6 alpha-beta
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Glycine zipper 2TM domain-containing protein
RNA polymerase sigma factor 70 region 4 type 2
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Gamma-glutamylcyclotransferase AIG2-like
6-phosphogluconate dehydrogenase C-terminal
Flagellar Assembly Protein A N-terminal region
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
S-adenosylmethionine-dependent methyltransferase
Release factor glutamine methyltransferase N-terminal
DNA replication/recombination mediator RecO N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
Saccharopine dehydrogenase-like C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Outer membrane protein assembly factor BamA
Chromosomal replication initiator DnaA C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Ion-translocating oxidoreductase complex subunit G
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Alpha-D-phosphohexomutase alpha/beta/alpha
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Large ribosomal subunit protein bL25 L25
SD-repeat containing protein B domain-containing protein
Exonuclease VII large subunit C-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Resolvase/invertase-type recombinase catalytic
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Carbamoyl-phosphate synthase small subunit N-terminal
Flagellar motor switch protein FliN-like C-terminal
Beta-hexosaminidase bacterial type N-terminal
Important for substrate binding and specificity
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Phosphatidic acid phosphatase type 2/haloperoxidase
Plays an important role in substrate specificity
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Putative beta-barrel assembly-enhancing protease
Polysaccharide chain length determinant N-terminal
Polysaccharide biosynthesis protein CapD-like
Penicillin-binding protein activator LpoA
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Homogentisate 1,2-dioxygenase N-terminal
CobB/CobQ-like glutamine amidotransferase
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Thymidylate synthase/dCMP hydroxymethylase
Pyrimidine nucleoside phosphorylase C-terminal
Essential for prephenate dehydratase activity
Helix-hairpin-helix DNA-binding motif class 1
Signal transduction histidine kinase 5TM receptor LytS transmembrane region
Signal transduction histidine kinase internal region
Aminoacyl-tRNA synthetase class I anticodon-binding
Autoinducer 2-binding periplasmic protein LuxP
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Glycosyl transferase family 3 N-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
DNA-directed DNA polymerase family A palm
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport
Mediates proton transfer from the protein to the inner aqueous phase
Important for beta-aspartyl-AMP intermediate formation
Type III secretion system flagellar brake protein YcgR PilZN
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Menaquinone biosynthesis protein MenD middle
Cytochrome oxidase subunit II transmembrane region profile
Large ribosomal subunit protein uL2 C-terminal
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Replication initiator protein RctB central region
Chitobiase/beta-hexosaminidases N-terminal
Oxidoreductase molybdopterin-binding domain-containing protein
Transition state stabilizer; via amide nitrogen
Glucosamine/galactosamine-6-phosphate isomerase
Peptide methionine sulphoxide reductase MsrA
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Translation elongation factor P/YeiP central
Schiff-base intermediate with acetaldehyde
DNA polymerase III subunit delta C-terminal
Involved in allosteric activation by GTP
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Reversibly protonated during proton transport
RNA 2-O ribose methyltransferase substrate binding
Type II secretion system protein GspG C-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Type II secretion system pilot lipoprotein GspS-beta
Outer membrane protein assembly factor BamB
NIF system FeS cluster assembly NifU C-terminal
Bacterial transcriptional activator domain-containing protein
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Pyruvate phosphate dikinase AMP/ATP-binding
Molybdopterin cofactor biosynthesis C (MoaC)
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Haem-binding uptake Tiki superfamily ChaN
Haem-binding uptake Tiki superfamily ChaN domain-containing protein
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Small-conductance mechanosensitive channel
Required for zinc-mediated homotetramerization and catalytic activity
Outer membrane protein assembly factor BamC
Putative Flp pilus-assembly TadG-like N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Chitin-binding type-3 domain-containing protein
Electron transfer via tryptophanyl radical
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Peptidase M10 metallopeptidase domain-containing protein
Ribose-phosphate pyrophosphokinase N-terminal
Formate-dependent nitrite reductase complex subunit
Membrane insertase YidC/Oxa/ALB C-terminal
Erythronate-4-phosphate dehydrogenase dimerisation
Glycoside hydrolase family 31 N-terminal
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Sodium/calcium exchanger membrane region
High-affinity zinc uptake system protein ZnuA
SUF system FeS cluster assembly SufBD N-terminal
Alpha-glycerophosphate oxidase C-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
Alkyl sulfatase dimerisation domain-containing protein
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Threonine/serine exporter-like N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Translocation and assembly module subunit TamA
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Pseudouridine synthase I TruA alpha/beta
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-96)
Important for interaction with partner proteins
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Positions MEP for the nucleophilic attack
NADH-rubredoxin oxidoreductase C-terminal
Helix-hairpin-helix DNA-binding motif class 1 domain-containing protein
Phosphotransferase system enzyme I N-terminal
Major facilitator superfamily associated
Mannose-6-phosphate isomerase type II C-terminal
Survival protein SurE-like phosphatase/nucleotidase
Transcription elongation factor GreA/GreB N-terminal
Transglycosylase SLT domain-containing protein
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Biopterin-dependent aromatic amino acid hydroxylase family profile
Type I restriction modification DNA specificity
Rap1a immunity protein domain-containing protein
Thiol:disulfide interchange protein DsbD
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
O-(phosphoribosyl dephospho-coenzyme A)serine
Glycine cleavage T-protein C-terminal barrel
Pyruvate dehydrogenase E1 component middle
Right handed beta helix domain-containing protein
HTH-type transcriptional regulator MT1864/Rv1816-like C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Type II secretion system protein GspI C-terminal
Arginine decarboxylase C-terminal helical
Appears to be important in orienting the phosphate for catalysis
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
DNA-directed RNA polymerase RpoA/D/Rpb3-type
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Involved in tetramerization or stability of the tetramer
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Nucleophile; cysteine thiosulfonate intermediate
Disulphide bond isomerase DsbC/G N-terminal
Cob(I)alamin adenosyltransferase N-terminal
Urease accessory protein UreH-like transmembrane
Small ribosomal subunit protein uS4 N-terminal
Regulator of nucleoside diphosphate kinase N-terminal
Flagellar hook-length control protein-like C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Cytochrome oxidase subunit II copper A binding
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Lysidine-tRNA(Ile) synthetase C-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Na(+)-translocating NADH-quinone reductase subunit A C-terminal