NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Major facilitator superfamily (MFS) profile
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
RND efflux pump membrane fusion protein barrel-sandwich
Glycine cleavage T-protein C-terminal barrel
Flagellar motor switch protein FliN-like C-terminal
Survival protein SurE-like phosphatase/nucleotidase
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Large ribosomal subunit protein uL15/eL18
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Important for beta-aspartyl-AMP intermediate formation
YMGG-like Gly-zipper domain-containing protein
Prokaryotic-type class I peptide chain release factors
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
TonB-dependent receptor-like beta-barrel
Essential for prephenate dehydratase activity
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Sec translocon accessory complex subunit YajC
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
O-(5'-phospho-DNA)-tyrosine intermediate
Transcription elongation factor GreA/GreB C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glycosyltransferase subfamily 4-like N-terminal
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Putative auto-transporter adhesin head GIN
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Aminoacyl-transfer RNA synthetases class-II family profile
Penicillin-binding protein transpeptidase
Tryptophan synthase beta chain-like PALP
Membrane fusion protein biotin-lipoyl like
Glucosamine/galactosamine-6-phosphate isomerase
NAD(P) transhydrogenase alpha subunit C-terminal
NIF system FeS cluster assembly NifU N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Resolvase/invertase-type recombinase catalytic
Bacterial type II secretion system protein E
RlpA-like protein double-psi beta-barrel
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Peptidase S9 prolyl oligopeptidase catalytic
Electron transfer via tryptophanyl radical
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Phosphoribosylformylglycinamidine synthase linker
ATP synthase F1 complex delta/epsilon subunit N-terminal
Cytochrome c-type biogenesis protein CcmE
Shikimate dehydrogenase substrate binding N-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
S-adenosylmethionine-dependent methyltransferase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Interaction with polymerase core subunit RpoC
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
PhoD-like phosphatase metallophosphatase
RNA polymerase sigma factor 70 region 4 type 2
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Cysteine sulfenic acid (-SOH) intermediate
DNA topoisomerase I catalytic core eukaryotic-type
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Glycosyl-hydrolase 97 C-terminal oligomerisation
DNA mismatch repair proteins mutS family
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Flagella basal body P-ring formation protein FlgA C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Tetrahydrodipicolinate-N-succinyltransferase chain A
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Glycosyl transferase family 3 N-terminal
Cytochrome oxidase subunit II copper A binding
Endolytic peptidoglycan transglycosylase RlpA
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
DNA-directed DNA polymerase family A palm
Cytochrome b561 bacterial/Ni-hydrogenase
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Plays an important role in substrate specificity
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-127)
Ribosomal RNA adenine methylase transferase N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Putative Flp pilus-assembly TadG-like N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Heme-copper oxidase subunit III family profile
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Bacterial bifunctional deaminase-reductase C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Beta-xylosidase C-terminal Concanavalin A-like
Cobaltochelatase subunit CobS N-terminal
Peptide methionine sulphoxide reductase MsrA
Phosphoadenosine phosphosulphate reductase
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Restriction endonuclease type II EcoRII C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Methionyl-tRNA synthetase anticodon-binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Anthranilate synthase component I N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Conjugal transfer pilus assembly protein TraA
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Type VI secretion system IcmF C-terminal
Outer membrane protein assembly factor BamD
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Pyruvate phosphate dikinase AMP/ATP-binding
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
tRNA pseudouridylate synthase B C-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Polymerase/histidinol phosphatase N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Peptidase M1 membrane alanine aminopeptidase
Signal recognition particle SRP54 helical bundle
RNA 2-O ribose methyltransferase substrate binding
Poly-beta-hydroxybutyrate polymerase N-terminal
Moybdenum cofactor oxidoreductase dimerisation
Histidine phosphotransferase ChpT C-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Prepilin type IV endopeptidase peptidase
Aconitase A/isopropylmalate dehydratase small subunit swivel
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Heat-inducible transcription repressor HrcA C-terminal
CDP-alcohol phosphatidyltransferase C-terminal
C-type lysozyme inhibitor domain-containing protein
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Type II secretion system protein GspC N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Large ribosomal subunit protein uL2 C-terminal
Helix-hairpin-helix DNA-binding motif class 1
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Chromosomal replication initiator DnaA C-terminal
Organic solvent tolerance-like N-terminal
Beta-lactamase hydrolase-like protein phosphatase-like
Beta-hexosaminidase bacterial type N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Moves into active site upon enzyme activation, plays a role in electron transfer
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Carbamoyl-phosphate synthase small subunit N-terminal
Transcription elongation factor GreA/GreB N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Type IV secretion system coupling protein TraD DNA-binding
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Translation elongation factor P/YeiP central
Glycoside hydrolase family 31 N-terminal
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Proton acceptor; for glutaminase activity
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Flagellar hook-length control protein-like C-terminal
Glycoside-hydrolase family GH114 TIM-barrel
TtsA-like Glycoside hydrolase family 108
Schiff-base intermediate with dihydroxyacetone-P
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Pyruvate/ketoisovalerate oxidoreductase catalytic
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Aminoacyl-tRNA synthetase class I anticodon-binding
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Pseudouridine synthase I TruA alpha/beta
Could be important to modulate the pK values of the two catalytic cysteine residues
Sodium/calcium exchanger membrane region
Superoxide dismutase copper/zinc binding
Quercetin 2,3-dioxygenase C-terminal cupin
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Thymidylate synthase/dCMP hydroxymethylase
Alpha galactosidase C-terminal beta sandwich
6-phosphogluconate dehydrogenase C-terminal
General stress protein FMN-binding split barrel
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Small ribosomal subunit protein uS4 N-terminal
Cytochrome C biogenesis protein transmembrane
Thiol:disulfide interchange protein DsbD N-terminal
Probable periplasmic serine endoprotease DegP-like
147-fold decrease in catalytic efficiency for L-serine. Affects the chemistry of the pyridoxal phosphate.
23-fold decrease in catalytic efficiency for L-serine.
40-fold decrease in catalytic efficiency for L-serine. Is less able to stabilize a quinonoid intermediate.
410-fold decrease in catalytic efficiency for L-serine. Affects the chemistry of the pyridoxal phosphate. Is less able to stabilize a quinonoid intermediate.
60-fold decrease in catalytic efficiency for L-serine.
Histidine-specific methyltransferase SAM-dependent
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
NADH-rubredoxin oxidoreductase C-terminal
Biopterin-dependent aromatic amino acid hydroxylase family profile
Peptide methionine sulfoxide reductase MsrA
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-101)
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
Glycoside hydrolase family 42 N-terminal
YpeB-like protein with protease inhibitory function
Flagellar assembly protein FliH/Type III secretion system HrpE
O-(3'-phospho-DNA)-tyrosine intermediate
Molybdopterin cofactor biosynthesis C (MoaC)
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Chitobiase/beta-hexosaminidases N-terminal
Exonuclease VII large subunit C-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
PHA accumulation regulator DNA-binding N-terminal
Reversibly protonated during proton transport
Alanyl-transfer RNA synthetases family profile
Glutathionylspermidine synthase pre-ATP-grasp-like
Cytochrome oxidase subunit II transmembrane region profile
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
N-end rule aminoacyl transferase C-terminal
Nucleophile; cysteine thiosulfonate intermediate
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
RNA binding; important for wobble base 34 recognition