6-phosphogluconate dehydrogenase C-terminal
DNA replication/recombination mediator RecO N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Alpha-D-phosphohexomutase alpha/beta/alpha
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Gfo/Idh/MocA-like oxidoreductase N-terminal
SUF system FeS cluster assembly SufBD N-terminal
RNA 2-O ribose methyltransferase substrate binding
Anthranilate synthase component I N-terminal
Reversibly protonated during proton transport
Mandelate racemase/muconate lactonizing enzyme C-terminal
Cell envelope-related transcriptional attenuator
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Penicillin-binding protein transpeptidase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Inosine/uridine-preferring nucleoside hydrolase
Interaction with polymerase core subunit RpoC
Phosphoribosylformylglycinamidine synthase linker
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Peptidase S9 prolyl oligopeptidase catalytic
Phosphatidic acid phosphatase type 2/haloperoxidase
Membrane insertase YidC/Oxa/ALB C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Schiff-base intermediate with substrate; via pyruvic acid
Major facilitator superfamily (MFS) profile
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Meso-diaminopimelate D-dehydrogenase C-terminal
Ribosome maturation factor RimP N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Phosphocysteine intermediate; for EIIB activity
Essential for prephenate dehydratase activity
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Solute-binding protein family 3/N-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Na+/H+ antiporter MnhB subunit-related protein
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Schiff-base intermediate with D-ribose 5-phosphate
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Prokaryotic-type class I peptide chain release factors
Important for substrate specificity; cannot use PPi as phosphoryl donor
Molybdopterin cofactor biosynthesis C (MoaC)
NADH:flavin oxidoreductase/NADH oxidase N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Type I restriction modification DNA specificity
Actinobacterial surface-anchored protein domain
Bacterial bifunctional deaminase-reductase C-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
Glucosamine/galactosamine-6-phosphate isomerase
Fibrinogen C-terminal domain-containing protein
RNA polymerase sigma factor 70 region 4 type 2
Alanyl-transfer RNA synthetases family profile
Resuscitation-promoting factor Rpf1 C-terminal
Resuscitation-promoting factor core lysozyme-like
ABC-type glycine betaine transport system substrate-binding
Large ribosomal subunit protein uL6 alpha-beta
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Phenol hydroxylase C-terminal dimerisation
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Translation elongation factor P/YeiP central
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Phosphomannose isomerase type I catalytic
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Threonine/serine exporter-like N-terminal
Sporulation transcription regulator WhiA N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Cytochrome b/b6 N-terminal region profile
Pyruvate dehydrogenase E1 component middle
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Pseudouridine synthase I TruA alpha/beta
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Periplasmic lipoprotein involved in iron transport
4'-phosphopantetheinyl transferase N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Important for beta-aspartyl-AMP intermediate formation
Cell wall-active antibiotics response LiaF-like C-terminal
Chromosomal replication initiator DnaA C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Activator of Hsp90 ATPase homologue 1-like C-terminal
Methionyl-tRNA synthetase anticodon-binding
O-(5'-phospho-DNA)-tyrosine intermediate
Resolvase/invertase-type recombinase catalytic
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
CobB/CobQ-like glutamine amidotransferase
Shikimate dehydrogenase substrate binding N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
O-(3'-phospho-DNA)-tyrosine intermediate
Glycosyltransferase subfamily 4-like N-terminal
Restriction system protein Mrr-like N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Cysteine sulfenic acid (-SOH) intermediate
Phosphatidate phosphatase APP1 catalytic
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Phosphotransferase system enzyme I N-terminal
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Plays an important role in substrate specificity
Tryptophan synthase beta chain-like PALP
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Small ribosomal subunit protein uS4 N-terminal
Bacterial transcription activator effector binding
Exonuclease VII large subunit C-terminal
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Large ribosomal subunit protein uL15/eL18
Polymerase/histidinol phosphatase N-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Peptide methionine sulphoxide reductase MsrA
Glycosyl transferase family 3 N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
RNA binding; important for wobble base 34 recognition
Cation-transporting P-type ATPase N-terminal
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Could play a key role in the communication between the regulatory and the substrate sites
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
N6 adenine-specific DNA methyltransferase N-terminal
Involved in ionization of N3 of dUMP, leading to its activation
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Peptidase M1 membrane alanine aminopeptidase
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
NIF system FeS cluster assembly NifU N-terminal
Release factor glutamine methyltransferase N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Nitrite/Sulfite reductase ferredoxin-like
Large ribosomal subunit protein uL2 C-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Schiff-base intermediate with acetaldehyde
Bacterial type II secretion system protein E
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Polysaccharide biosynthesis protein C-terminal
Glycine cleavage T-protein C-terminal barrel
Gly-cisPro motif, important for rejection of L-amino acids
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Cytochrome C biogenesis protein transmembrane
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Thymidylate synthase/dCMP hydroxymethylase