Penicillin-binding protein transpeptidase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Lysyl-tRNA synthetase N-terminal transmembrane region
Phosphatidylglycerol lysyltransferase C-terminal
Major facilitator superfamily (MFS) profile
LPXTG cell wall anchor domain-containing protein
Transglycosylase SLT domain-containing protein
Heat-inducible transcription repressor HrcA C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Schiff-base intermediate with substrate; via pyruvic acid
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
N-acetylneuraminic acid synthase N-terminal
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Pyridoxamine 5'-phosphate oxidase putative
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
PhoD-like phosphatase metallophosphatase
Transposase IS116/IS110/IS902 C-terminal
ABC-type glycine betaine transport system substrate-binding
N,N-dimethylformamidase beta subunit-like C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Polymerase/histidinol phosphatase N-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
6-phosphogluconate dehydrogenase C-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Formamidopyrimidine-DNA glycosylase catalytic
Lon proteolytic domain-containing protein
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Peptidoglycan binding-like domain-containing protein
Cell wall-active antibiotics response LiaF-like C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Release factor glutamine methyltransferase N-terminal
DNA primase/polymerase bifunctional N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
DnaJ homologue subfamily C member 28 conserved
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Peptide methionine sulphoxide reductase MsrA
Solute-binding protein family 5 domain-containing protein
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Transcription regulator AsnC/Lrp ligand binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Tryptophan synthase beta chain-like PALP
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Tat pathway signal sequence domain protein
Ricin B lectin domain-containing protein
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Pyridine nucleotide-disulphide oxidoreductase dimerisation
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Glycosyltransferase subfamily 4-like N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
NADH-rubredoxin oxidoreductase C-terminal
NIF system FeS cluster assembly NifU C-terminal
Important for beta-aspartyl-AMP intermediate formation
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Cell envelope-related transcriptional attenuator
Gram-positive cocci surface proteins LPxTG domain-containing protein
RNA 2-O ribose methyltransferase substrate binding
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Peptidase M1 membrane alanine aminopeptidase
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Cytochrome oxidase subunit II copper A binding
Prokaryotic-type class I peptide chain release factors
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Alpha-D-phosphohexomutase alpha/beta/alpha
Alpha-glycerophosphate oxidase C-terminal
Pyruvate dehydrogenase E1 component middle
Cytochrome bc1 complex Rieske iron-sulfur subunit
Proton acceptor; for glutaminase activity
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Small ribosomal subunit protein uS4 N-terminal
Anthranilate synthase component I N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Glycerophosphoryl diester phosphodiesterase membrane
DNA-directed DNA polymerase family A palm
Phosphocysteine intermediate; for EIIB activity
Gram-positive cocci surface proteins LPxTG
Helix-hairpin-helix DNA-binding motif class 1
Pyrimidine nucleoside phosphorylase C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Acetylserotonin O-methyltransferase dimerisation
ABC transporter substrate-binding protein PnrA-like
Cucumopine synthase C-terminal helical bundle
Large ribosomal subunit protein uL15/eL18
Solute-binding protein family 3/N-terminal
Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Myo-inositol-1-phosphate synthase GAPDH-like
Bacterial bifunctional deaminase-reductase C-terminal
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
DNA replication/recombination mediator RecO N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Type II restriction enzyme and methyltransferase RM.Eco57I-like
Important for substrate specificity; cannot use PPi as phosphoryl donor
Magnesium transporter MgtE intracellular
Phosphoribosylformylglycinamidine synthase linker
Glucose-methanol-choline oxidoreductase C-terminal
Cytochrome b/b6 N-terminal region profile
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Phosphotransferase system enzyme I N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Putative regulatory protein FmdB Zinc ribbon
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Bacterial type II secretion system protein E
Thiamine pyrophosphate enzyme TPP-binding
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Squalene cyclase C-terminal domain-containing protein
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
CobB/CobQ-like glutamine amidotransferase
Electron transfer via tryptophanyl radical
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Polysaccharide chain length determinant N-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Involved in allosteric activation by GTP
Plays an important role in substrate specificity
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Proteinase inhibitor I42 chagasin domain-containing protein
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Nuclear transport factor 2 family protein
Adaptive response protein AidB N-terminal
NIF system FeS cluster assembly NifU N-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Quercetin 2,3-dioxygenase C-terminal cupin
Glycosyl transferase family 3 N-terminal
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Aconitase A/isopropylmalate dehydratase small subunit swivel
Involved in ionization of N3 of dUMP, leading to its activation
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Schiff-base intermediate with dihydroxyacetone-P
Cytochrome b561 bacterial/Ni-hydrogenase
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Phosphomannose isomerase type I catalytic
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Methionyl-tRNA synthetase anticodon-binding
Reversibly protonated during proton transport
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Heme-copper oxidase subunit III family profile
Transition state stabilizer; via amide nitrogen
Essential for prephenate dehydratase activity
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Large ribosomal subunit protein uL6 alpha-beta
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Cysteine sulfenic acid (-SOH) intermediate
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transposase IS204/IS1001/IS1096/IS1165 helix-turn-helix
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
Prepilin type IV endopeptidase peptidase
Sporulation transcription regulator WhiA N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Acyltransferase MbtK/IucB-like conserved
Positions MEP for the nucleophilic attack
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glucosamine/galactosamine-6-phosphate isomerase
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Pseudouridine synthase I TruA alpha/beta
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Carboxypeptidase regulatory-like domain-containing protein
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Probable subtilase-type protease inhibitor
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Threonine/serine exporter-like N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Glycine cleavage T-protein C-terminal barrel
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
YbaK/aminoacyl-tRNA synthetase-associated
Translation elongation factor P/YeiP central
Inosine/uridine-preferring nucleoside hydrolase
Putative glycogen debranching enzyme N-terminal
Styrene monooxygenase StyA putative substrate binding
Putative oxidoreductase/dehydrogenase Rossmann-like
Large ribosomal subunit protein uL2 C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Ribosomal RNA adenine methylase transferase N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Interaction with polymerase core subunit RpoC
Exonuclease VII large subunit C-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Conserved hypothetical protein CHP02679 N terminus
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
ATP synthase F1 complex delta/epsilon subunit N-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Right handed beta helix domain-containing protein
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-106)
CD-NTase-associated protein 12/Pycsar effector protein TIR
Cytochrome bc1 complex cytochrome c subunit
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Pyruvate phosphate dikinase AMP/ATP-binding
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Dystroglycan-type cadherin-like domain-containing protein
Shikimate dehydrogenase substrate binding N-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
MmyB-like transcription regulator ligand binding
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Sodium/calcium exchanger membrane region
SUF system FeS cluster assembly SufBD N-terminal
Integral membrane protein YccS N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
L,D-transpeptidase catalytic domain-containing protein
Schiff-base intermediate with D-ribose 5-phosphate
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Capsule synthesis protein CapA domain-containing protein
Diacylglycerol glucosyltransferase N-terminal
Subtilisin inhibitor domain-containing protein
Alanyl-transfer RNA synthetases family profile
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Histidine-specific methyltransferase SAM-dependent
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Ribose-phosphate pyrophosphokinase N-terminal
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Removed in mature form; by autocatalysis
Ionotropic glutamate receptor C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding