Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Acyl-CoA dehydrogenase/oxidase C-terminal
RNA 2-O ribose methyltransferase substrate binding
Could play a key role in the communication between the regulatory and the substrate sites
Glycerophosphoryl diester phosphodiesterase family protein
Glycoside hydrolase family 42 N-terminal
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Activator of Hsp90 ATPase homologue 1-like C-terminal
Major facilitator superfamily (MFS) profile
SurA N-terminal domain-containing protein
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
DNA primase/polymerase bifunctional N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Peptidoglycan binding-like domain-containing protein
Gram-positive cocci surface proteins LPxTG domain-containing protein
ABC transporter substrate-binding protein
Solute-binding protein family 5 domain-containing protein
Polymerase/histidinol phosphatase N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Sodium/calcium exchanger membrane region
SUF system FeS cluster assembly SufBD N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Large ribosomal subunit protein uL15/eL18
Penicillin-binding protein transpeptidase
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Acyl-CoA dehydrogenase/oxidase N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Dipeptidylpeptidase IV N-terminal domain-containing protein
Septum formation-related domain-containing protein
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Transition state stabilizer; via amide nitrogen
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
RNA polymerase sigma factor 70 region 4 type 2
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Saccharopine dehydrogenase-like C-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Tryptophan synthase beta chain-like PALP
NADH:flavin oxidoreductase/NADH oxidase N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Alpha-glycerophosphate oxidase C-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Transcription regulator HTH AraC N-terminal
Bacterial Ig-like domain-containing protein
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Interaction with polymerase core subunit RpoC
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Aromatic amino acid beta-eliminating lyase/threonine aldolase
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Important for substrate specificity; cannot use PPi as phosphoryl donor
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Ribosomal RNA adenine methylase transferase N-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Beta-lactamase-related domain-containing protein
Lactate utilization protein B C-terminal
Cell envelope-related transcriptional attenuator
Tat pathway signal sequence domain protein
Anthranilate synthase component I N-terminal
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Pyridoxamine 5'-phosphate oxidase putative
Mandelate racemase/muconate lactonizing enzyme C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
Phosphoadenosine phosphosulphate reductase
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
6-phosphogluconate dehydrogenase NADP-binding
6-phosphogluconate dehydrogenase NADP-binding domain-containing protein
Peptidase S8/S53 domain-containing protein
Glycine cleavage T-protein C-terminal barrel
ABC transporter substrate-binding protein PnrA-like
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Threonine/serine exporter-like N-terminal
PhoD-like phosphatase metallophosphatase
Pyruvate dehydrogenase E1 component middle
Peptidase M14 carboxypeptidase A domain-containing protein
Pyruvate phosphate dikinase AMP/ATP-binding
Essential for prephenate dehydratase activity
Membrane insertase YidC/Oxa/ALB C-terminal
Important for beta-aspartyl-AMP intermediate formation
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
N6 adenine-specific DNA methyltransferase N-terminal
Prepilin type IV endopeptidase peptidase
Sugar ABC transporter substrate-binding protein
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Aminoacyl-transfer RNA synthetases class-II family profile
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Solute-binding protein family 3/N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Phosphoribosylformylglycinamidine synthase linker
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Aconitase A/isopropylmalate dehydratase small subunit swivel
Alanyl-transfer RNA synthetases family profile
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
Chitin-binding type-4 domain-containing protein
Alpha-D-phosphohexomutase alpha/beta/alpha
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Ricin B lectin domain-containing protein
Pyrroline-5-carboxylate reductase catalytic N-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Solute-binding protein family 3/N-terminal domain-containing protein
Galactose oxidase-like Early set domain-containing protein
Alginate lyase domain-containing protein
2-oxoacid dehydrogenase acyltransferase catalytic
AB hydrolase-1 domain-containing protein
Bacterial bifunctional deaminase-reductase C-terminal
Cytochrome bc1 complex Rieske iron-sulfur subunit
Damage-control phosphatase ARMT1-like metal-binding
Glucosamine/galactosamine-6-phosphate isomerase
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
NADH:ubiquinone oxidoreductase-like 20kDa subunit
FAD-binding PCMH-type domain-containing protein
PknH-like extracellular domain-containing protein
Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein
Signal recognition particle SRP54 helical bundle
Polysaccharide lyase 8 N-terminal alpha-helical
Polysaccharide lyase family 8 C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Glycosyl transferase family 3 N-terminal
Microcin J25-processing protein McjB C-terminal
DnaJ homologue subfamily C member 28 conserved
6-phosphogluconate dehydrogenase C-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal domain-containing protein
Capsule synthesis protein CapA domain-containing protein
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Could be important to modulate the pK values of the two catalytic cysteine residues
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
CobB/CobQ-like glutamine amidotransferase
Prokaryotic-type class I peptide chain release factors
Peptidoglycan recognition protein family
Peptidoglycan recognition protein family domain-containing protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
4'-phosphopantetheinyl transferase N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Subtilisin inhibitor domain-containing protein
Peptidase M1 membrane alanine aminopeptidase
Methionyl-tRNA synthetase anticodon-binding
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-108)
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Pectate lyase superfamily protein domain-containing protein
EfeO-type cupredoxin-like domain-containing protein
Large ribosomal subunit protein uL2 C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Involved in allosteric activation by GTP
Glucose/Sorbosone dehydrogenase domain-containing protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Nicotinate phosphoribosyltransferase N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
DNA-directed DNA polymerase family A palm
Histidine-specific methyltransferase SAM-dependent
Type ISP restriction-modification enzyme LLaBIII C-terminal specificity
Cytochrome b/b6 N-terminal region profile
Cytochrome C biogenesis protein transmembrane
Involved in ionization of N3 of dUMP, leading to its activation
N-acetylneuraminic acid synthase N-terminal
Neutral/alkaline non-lysosomal ceramidase C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
Bulb-type lectin domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Transcription regulator AsnC/Lrp ligand binding
Cell wall-active antibiotics response LiaF-like C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Methylguanine DNA methyltransferase ribonuclease-like
Sporulation transcription regulator WhiA N-terminal
Gram-positive cocci surface proteins LPxTG
Endoribonuclease L-PSP/chorismate mutase-like
Transglycosylase SLT domain-containing protein
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Glycosyl hydrolases family 2 sugar binding
Pseudouridine synthase I TruA alpha/beta
YbaK/aminoacyl-tRNA synthetase-associated
Chitin-binding type-3 domain-containing protein
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
N-acetylmuramoyl-L-alanine amidase domain-containing protein
Amidohydrolase-related domain-containing protein
Right handed beta helix domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
PhoD-like phosphatase metallophosphatase domain-containing protein
DNA replication/recombination mediator RecO N-terminal
SGNH hydrolase-type esterase domain-containing protein
Beta-hexosaminidase bacterial type N-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Alpha-N-acetylglucosaminidase C-terminal
Alpha-N-acetylglucosaminidase N-terminal
Alpha-N-acetylglucosaminidase tim-barrel
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
SsuA/THI5-like domain-containing protein
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Phosphatidylinositol-specific phospholipase C X
Large ribosomal subunit protein uL6 alpha-beta
Removed in mature form; by autocatalysis
Phosphomannose isomerase type I catalytic
Nucleophile; cysteine thiosulfonate intermediate
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Styrene monooxygenase StyA putative substrate binding
Prealbumin-like fold domain-containing protein
ATP synthase F1 complex delta/epsilon subunit N-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
Penicillin-binding protein transpeptidase domain-containing protein
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Positions MEP for the nucleophilic attack
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Fucolectin tachylectin-4 pentraxin-1 domain-containing protein
Putative glycogen debranching enzyme N-terminal
N,N-dimethylformamidase beta subunit-like C-terminal
Moybdenum cofactor oxidoreductase dimerisation
ABC-type glycine betaine transport system substrate-binding
Peptidase S1A alpha-lytic prodomain domain-containing protein
Flavodoxin-like domain-containing protein
Silent information regulator protein Sir2
Plays an important role in substrate specificity
Exonuclease VII large subunit C-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glycoside-hydrolase family GH114 TIM-barrel
Glycoside-hydrolase family GH114 TIM-barrel domain-containing protein
Helix-hairpin-helix DNA-binding motif class 1
vWA-MoxR associated protein middle region 0
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Small ribosomal subunit protein uS4 N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
O-(5'-phospho-DNA)-tyrosine intermediate
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
LamG-like jellyroll fold domain-containing protein
Heavy metal-binding domain-containing protein
Glycoside hydrolase family 19 catalytic domain-containing protein
Resolvase/invertase-type recombinase catalytic
Translation elongation factor P/YeiP central
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Fe/B12 periplasmic-binding domain-containing protein
Glycoside hydrolase family 31 N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Endonuclease/exonuclease/phosphatase domain-containing protein
Electron transfer via tryptophanyl radical
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Heat-inducible transcription repressor HrcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Bacterial type II secretion system protein E
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
NIF system FeS cluster assembly NifU N-terminal