DNA-directed DNA polymerase family A palm
Glycosyltransferase subfamily 4-like N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Activator of Hsp90 ATPase homologue 1-like C-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Major facilitator superfamily (MFS) profile
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Membrane fusion protein biotin-lipoyl like
Translation elongation factor P/YeiP central
Helix-hairpin-helix DNA-binding motif class 1
Bacterial type II secretion system protein E
Large ribosomal subunit protein uL15/eL18
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
TonB-dependent receptor-like beta-barrel
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Outer membrane protein assembly factor BamB
Solute-binding protein family 3/N-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Flagellar hook-length control protein-like C-terminal
Type VI secretion system IcmF C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
RNA binding; important for wobble base 34 recognition
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Important for interaction with partner proteins
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Tat (Twin-arginine translocation) pathway signal sequence domain protein
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Tryptophan synthase beta chain-like PALP
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase family protein
Bacterial bifunctional deaminase-reductase C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
NIF system FeS cluster assembly NifU N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Putative regulatory protein FmdB Zinc ribbon
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Cytochrome b561 bacterial/Ni-hydrogenase
Positions MEP for the nucleophilic attack
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Quercetin 2,3-dioxygenase C-terminal cupin
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Alpha-glycerophosphate oxidase C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
PEP-CTERM exosortase interaction domain protein
Superoxide dismutase copper/zinc binding
Putative auto-transporter adhesin head GIN
Putative auto-transporter adhesin head GIN domain-containing protein
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Alpha-D-phosphohexomutase alpha/beta/alpha
Alanyl-transfer RNA synthetases family profile
Could be important to modulate the pK values of the two catalytic cysteine residues
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Disulphide bond isomerase DsbC/G N-terminal
Exonuclease VII large subunit C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Solute-binding protein family 3/N-terminal domain-containing protein
Antitoxin Xre/MbcA/ParS-like toxin-binding
Histidine-specific methyltransferase SAM-dependent
Penicillin-binding protein transpeptidase
Schiff-base intermediate with acetoacetate
DNA polymerase III subunit delta C-terminal
Thiopeptide-type bacteriocin biosynthesis
Interaction with polymerase core subunit RpoC
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Mandelate racemase/muconate lactonizing enzyme C-terminal
Release factor glutamine methyltransferase N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Gp5/Type VI secretion system Vgr protein OB-fold
Putative type VI secretion system Rhs element associated Vgr
Proton acceptor; for glutaminase activity
Cation-transporting P-type ATPase N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Important for beta-aspartyl-AMP intermediate formation
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Thymidylate synthase/dCMP hydroxymethylase
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Putative oxidoreductase/dehydrogenase Rossmann-like
Endolytic peptidoglycan transglycosylase RlpA
Outer membrane protein assembly factor BamA
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Pyruvate phosphate dikinase AMP/ATP-binding
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Adaptive response protein AidB N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Urease accessory protein UreH-like transmembrane
peptide-methionine (R)-S-oxide reductase
Glycine cleavage T-protein C-terminal barrel
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Gly-cisPro motif, important for rejection of L-amino acids
ABC-type transport auxiliary lipoprotein component
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Transposase IS204/IS1001/IS1096/IS1165 DDE
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Polymerase/histidinol phosphatase N-terminal
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Required for dimer formation and molybdate binding
N-end rule aminoacyl transferase C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
ATP synthase F1 complex delta/epsilon subunit N-terminal
Prokaryotic-type class I peptide chain release factors
Thiol:disulfide interchange protein DsbA
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Polysaccharide chain length determinant N-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
HicB-like antitoxin of toxin-antitoxin system
Pseudouridine synthase I TruA alpha/beta
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
RNA 2-O ribose methyltransferase substrate binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Heme-copper oxidase subunit III family profile
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Small ribosomal subunit protein uS4 N-terminal
Chromosomal replication initiator protein DnaA
Flagellar motor switch protein FliN-like C-terminal
PHA accumulation regulator DNA-binding N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Large ribosomal subunit protein uL6 alpha-beta
ABC transporter substrate-binding protein PnrA-like
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Essential for prephenate dehydratase activity
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Prepilin type IV endopeptidase peptidase
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
TonB C-terminal domain-containing protein
Cytochrome C biogenesis protein transmembrane
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Cysteine sulfenic acid (-SOH) intermediate
Polypeptide-transport-associated ShlB-type
Malonate/sodium symporter MadM subunit N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Lipoprotein SmpA/OmlA domain-containing protein
Survival protein SurE-like phosphatase/nucleotidase
Glycosyl transferase family 3 N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Pyruvate dehydrogenase E1 component middle
Pyrimidine nucleoside phosphorylase C-terminal
ABC-type glycine betaine transport system substrate-binding
Type II secretion system protein GspC N-terminal
Reversibly protonated during proton transport
TRAP C4-dicarboxylate transport system permease DctM subunit
Regulator of nucleoside diphosphate kinase N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
UDP N-acetylglucosamine O-acyltransferase C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
Type II secretion system protein GspG C-terminal
Electron transfer via tryptophanyl radical
Ribose-phosphate pyrophosphokinase N-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Phosphotransferase system enzyme I N-terminal
Transition state stabilizer; via amide nitrogen
Plays an important role in substrate specificity
Mannose-6-phosphate isomerase type II C-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Gamma-butyrobetaine hydroxylase-like N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Inhibitor of vertebrate lysozyme family protein
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Chromosomal replication initiator DnaA C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Anthranilate synthase component I N-terminal
Bacteriophage lambda Replication protein O N-terminal
Proline utilization A proline dehydrogenase N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Copper binding periplasmic CusF family protein
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Sodium symporter small subunit predicted
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
Cobalamin-independent methionine synthase MetE N-terminal