Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Polymerase/histidinol phosphatase N-terminal
Major facilitator superfamily (MFS) profile
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Pseudouridine synthase I TruA alpha/beta
Tryptophan synthase beta chain-like PALP
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Polysaccharide biosynthesis protein C-terminal
Essential for prephenate dehydratase activity
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Glycosyltransferase subfamily 4-like N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Helix-hairpin-helix DNA-binding motif class 1
Phosphocysteine intermediate; for EIIB activity
Aminoacyl-transfer RNA synthetases class-II family profile
Schiff-base intermediate with substrate; via topaquinone
Transposase IS116/IS110/IS902 C-terminal
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Cell envelope-related transcriptional attenuator
Mandelate racemase/muconate lactonizing enzyme C-terminal
Flagellar motor switch protein FliN-like C-terminal
Heme-copper oxidase subunit III family profile
FAD-dependent oxidoreductase 2 FAD binding
RNA 2-O ribose methyltransferase substrate binding
Sodium/calcium exchanger membrane region
Thymidylate synthase/dCMP hydroxymethylase
PsbP C-terminal domain-containing protein
Schiff-base intermediate with D-ribose 5-phosphate
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
tRNA pseudouridylate synthase B C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
O-(5'-phospho-DNA)-tyrosine intermediate
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Solute-binding protein family 3/N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Putative aromatic acid exporter C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Phosphatidic acid phosphatase type 2/haloperoxidase
Phosphomannose isomerase type I catalytic
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Flagellar hook-length control protein-like C-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Ionotropic glutamate receptor C-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Penicillin-binding protein transpeptidase
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Transcription regulator AsnC/Lrp ligand binding
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Periplasmic binding protein domain-containing protein
Peptide methionine sulphoxide reductase MsrA
Translation elongation factor P/YeiP central
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Activator of Hsp90 ATPase homologue 1-like C-terminal
Diacylglycerol glucosyltransferase N-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Sigma 54 modulation/S30EA ribosomal protein C-terminal
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Small ribosomal subunit protein uS4 N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Reversibly protonated during proton transport
Type III secretion system flagellar brake protein YcgR PilZN
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
General stress protein FMN-binding split barrel
Cation-transporting P-type ATPase N-terminal
Single-stranded-DNA-specific exonuclease RecJ C-terminal
NIF system FeS cluster assembly NifU N-terminal
Menaquinone biosynthesis protein MenD middle
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Polysaccharide biosynthesis protein CapD-like
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Cell wall-active antibiotics response LiaF-like C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Spore germination GerAC-like C-terminal domain-containing protein
Glucosamine/galactosamine-6-phosphate isomerase
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Prokaryotic-type class I peptide chain release factors
Tryptophan RNA-binding attenuator protein
Exonuclease VII large subunit C-terminal
D-galactarate/Altronate dehydratase C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Pesticidal crystal protein Cry22Aa Ig-like
Thiamin pyrophosphokinase thiamin-binding
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Endoribonuclease L-PSP/chorismate mutase-like
Carbamoyl-phosphate synthase small subunit N-terminal
Inner membrane protein YgaP-like transmembrane
DNA-directed DNA polymerase family A palm
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal domain-containing protein
DNA mismatch repair proteins mutS family
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Positions MEP for the nucleophilic attack
Involved in allosteric activation by GTP
Interaction with polymerase core subunit RpoC
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Urease accessory protein UreH-like transmembrane
Shikimate dehydrogenase substrate binding N-terminal
Calcineurin-like phosphoesterase domain-containing protein
Glycoside hydrolase family 31 N-terminal
SGNH hydrolase-type esterase domain-containing protein
Cyclophilin-like domain-containing protein
Resolvase/invertase-type recombinase catalytic
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Peptidase M14 carboxypeptidase A domain-containing protein
2,4-diaminopentanoate dehydrogenase C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Pyruvate ferredoxin oxidoreductase beta subunit C-terminal
6-phosphogluconate dehydrogenase C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Na+-translocating membrane potential-generating system MpsC
Cytochrome C biogenesis protein transmembrane
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Lysidine-tRNA(Ile) synthetase C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Alanyl-transfer RNA synthetases family profile
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
DNA replication/recombination mediator RecO N-terminal
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
SsuA/THI5-like domain-containing protein
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Large ribosomal subunit protein uL2 C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Superoxide dismutase copper/zinc binding
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Cytochrome P460 domain-containing protein
YbaK/aminoacyl-tRNA synthetase-associated
Pyrimidine nucleoside phosphorylase C-terminal
SUF system FeS cluster assembly SufBD N-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Methylguanine DNA methyltransferase ribonuclease-like
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Peptidoglycan binding-like domain-containing protein
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Important for beta-aspartyl-AMP intermediate formation
ABC-type glycine betaine transport system substrate-binding
Glycosyl hydrolase family 30 beta sandwich
Signal transduction histidine kinase internal region
O-(3'-phospho-DNA)-tyrosine intermediate
Plays an important role in substrate specificity
Sporulation initiation phosphotransferase B C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Cytochrome b/b6 N-terminal region profile
Schiff-base intermediate with acetaldehyde
Alpha-galactosidase NEW3 domain-containing protein
Alpha-glycerophosphate oxidase C-terminal
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Gly-cisPro motif, important for rejection of L-amino acids
ABC transporter periplasmic binding protein yphF
Phosphoribosylformylglycinamidine synthase linker
TRAP C4-dicarboxylate transport system permease DctM subunit
Polysaccharide chain length determinant N-terminal
Metallo-beta-lactamase domain-containing protein
Could be important to modulate the pK values of the two catalytic cysteine residues
Ribonucleotide reductase large subunit C-terminal
Cysteine sulfenic acid (-SOH) intermediate
Sporulation stage II protein D amidase enhancer LytB N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Inosine/uridine-preferring nucleoside hydrolase
Threonine/serine exporter-like N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
ABC transporter substrate-binding protein PnrA-like
Bacterial type II secretion system protein E
Molybdopterin cofactor biosynthesis C (MoaC)
Anthranilate synthase component I N-terminal
Cytochrome b/b6 C-terminal region profile
Dipicolinate synthase subunit A N-terminal
Important for interaction with partner proteins
Excalibur calcium-binding domain-containing protein
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Glycosyl transferase family 3 N-terminal
Microcin J25-processing protein McjB C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
RDXXRA motif of the pArg binding pocket involved in allosteric regulation
Lactate utilization protein B C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Ribose-phosphate pyrophosphokinase N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Na+/H+ antiporter MnhB subunit-related protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Global transcriptional regulator CodY C-terminal
Global transcriptional regulator CodY N-terminal
Non-canonical purine NTP phosphatase/PRRC1
DNA polymerase III delta subunit C-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Chromosomal replication initiator DnaA C-terminal
NIF system FeS cluster assembly NifU C-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Ribonucleotide reductase large subunit N-terminal
Phosphotransferase system enzyme I N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Flagellar assembly protein FliH/Type III secretion system HrpE
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
PhoD-like phosphatase metallophosphatase
ATP synthase F1 complex delta/epsilon subunit N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Magnesium transporter MgtE intracellular
Sporulation transcription regulator WhiA N-terminal
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Elongation factor G-binding protein N-terminal
Bacterial transcription activator effector binding
Sporulation stage IV protein A C-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Large ribosomal subunit protein uL15/eL18
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Solute-binding protein family 3/N-terminal domain-containing protein
RNA binding; important for wobble base 34 recognition
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain