Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Septum formation inhibitor MinC C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Saccharopine dehydrogenase-like C-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Pseudouridine synthase I TruA alpha/beta
Phosphotransferase system enzyme I N-terminal
Polysaccharide biosynthesis protein C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
Sporulation stage IV protein A C-terminal
Phosphatidylglycerol lysyltransferase C-terminal
DNA-directed DNA polymerase family A palm
RNA polymerase sigma factor 70 region 4 type 2
Solute-binding protein family 3/N-terminal
Essential for prephenate dehydratase activity
Nitrite/Sulfite reductase ferredoxin-like
Threonine/serine exporter-like N-terminal
Membrane fusion protein biotin-lipoyl like
Alpha-D-phosphohexomutase alpha/beta/alpha
DNA mismatch repair proteins mutS family
ATP synthase F1 complex delta/epsilon subunit N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Carbamoyl-phosphate synthase small subunit N-terminal
Glycosyltransferase subfamily 4-like N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Tetracyclin repressor SlmA-like C-terminal
Phosphoadenosine phosphosulphate reductase
Gfo/Idh/MocA-like oxidoreductase N-terminal
NADH-rubredoxin oxidoreductase C-terminal
Exonuclease VII large subunit C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Polysaccharide biosynthesis protein CapD-like
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Cell wall-active antibiotics response LiaF-like C-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Phosphomannose isomerase type I catalytic
RND efflux pump membrane fusion protein barrel-sandwich
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
ATPsynthase alpha/beta subunit N-terminal extension
Major facilitator superfamily (MFS) profile
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Aminoacyl-transfer RNA synthetases class-II family profile
Type I restriction modification DNA specificity
Ionotropic glutamate receptor C-terminal
Schiff-base intermediate with D-ribose 5-phosphate
YbaK/aminoacyl-tRNA synthetase-associated
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Probable transposase IS891/IS1136/IS1341
Cation-transporting P-type ATPase N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Putative host cell surface-exposed lipoprotein Ltp-like HTH region
Involved in allosteric activation by GTP
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Arabinogalactan endo-beta-1,4-galactanase
Lysidine-tRNA(Ile) synthetase C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Global transcriptional regulator CodY C-terminal
Global transcriptional regulator CodY N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Phosphocysteine intermediate; for EIIB activity
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Phosphoribosylformylglycinamidine synthase linker
S-adenosylmethionine-dependent methyltransferase
Positions MEP for the nucleophilic attack
Phosphatidic acid phosphatase type 2/haloperoxidase
Thymidylate synthase/dCMP hydroxymethylase
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Plays an important role in substrate specificity
Ribose-phosphate pyrophosphokinase N-terminal
Sugar fermentation stimulation protein C-terminal
Bacterial type II secretion system protein E
O-(phosphoribosyl dephospho-coenzyme A)serine
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Gp5/Type VI secretion system Vgr protein OB-fold
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Small ribosomal subunit protein uS4 N-terminal
Resolvase/invertase-type recombinase catalytic
Large ribosomal subunit protein uL15/eL18
Diacylglycerol glucosyltransferase N-terminal
Glycosyl transferase family 28 C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Tryptophan synthase beta chain-like PALP
ABC transporter substrate-binding protein PnrA-like
ABC transporter substrate-binding protein PnrA-like domain-containing protein
NIF system FeS cluster assembly NifU N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Polysaccharide chain length determinant N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Dinitrogenase iron-molybdenum cofactor biosynthesis
Bacterial transcription activator effector binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Microcin J25-processing protein McjB C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
FAD-dependent oxidoreductase 2 FAD binding
Penicillin-binding protein transpeptidase
Major facilitator superfamily associated
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Shikimate dehydrogenase substrate binding N-terminal
Translation elongation factor P/YeiP central
Prokaryotic-type class I peptide chain release factors
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Flagellar hook-length control protein-like C-terminal
Flagellar motor switch protein FliN-like C-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Pyridoxamine 5'-phosphate oxidase putative
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Survival protein SurE-like phosphatase/nucleotidase
Polymerase/histidinol phosphatase N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Chromosomal replication initiator DnaA C-terminal
6-hydroxymethylpterin diphosphokinase MptE-like
Phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease 4
Large ribosomal subunit protein uL30-like ferredoxin-like fold
DNA polymerase III delta subunit C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Transposon Tn7 transposition protein TnsD C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Large ribosomal subunit protein uL6 alpha-beta
Important for substrate specificity; cannot use PPi as phosphoryl donor
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Glucosamine/galactosamine-6-phosphate isomerase
Anthranilate synthase component I N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
1-phosphatidylinositol phosphodiesterase
Phosphatidylinositol-specific phospholipase C X
RNA 2-O ribose methyltransferase substrate binding
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Large ribosomal subunit protein uL2 C-terminal
Important for beta-aspartyl-AMP intermediate formation
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Flagellar Assembly Protein A N-terminal region
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Release factor glutamine methyltransferase N-terminal
Schiff-base intermediate with acetaldehyde
Pyridine nucleotide-disulphide oxidoreductase dimerisation
5-glutamyl coenzyme A thioester intermediate
Alanyl-transfer RNA synthetases family profile
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Molybdopterin cofactor biosynthesis C (MoaC)
Lantibiotic biosynthesis protein dehydration
Transcription regulator AsnC/Lrp ligand binding
Ribosomal RNA adenine methylase transferase N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Transglutaminase-like domain-containing protein
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Sodium/calcium exchanger membrane region
ATP-dependent DNA helicase RecG C-terminal
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Sporulation stage II protein D amidase enhancer LytB N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Glycosyltransferase family 28 N-terminal
Schiff-base intermediate with acetoacetate
Peptidase C39-like domain-containing protein
Phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease 3
Schiff-base intermediate with substrate; via pyruvic acid
Putative aromatic acid exporter C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Reversibly protonated during proton transport
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Type III secretion system flagellar brake protein YcgR PilZN
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Flagellar assembly protein FliH/Type III secretion system HrpE
RNA binding; important for wobble base 34 recognition
Molybdenum cofactor biosynthesis protein F N-terminal
Nicotinamide phosphoribosyltransferase N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
DNA replication/recombination mediator RecO N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Thiamin pyrophosphokinase thiamin-binding
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Could be important to modulate the pK values of the two catalytic cysteine residues
Helix-hairpin-helix DNA-binding motif class 1
Glycosyl transferase family 3 N-terminal
Proton acceptor; for glutaminase activity
Transposase IS116/IS110/IS902 C-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Lysozyme inhibitor LprI N-terminal domain-containing protein