Solute-binding protein family 3/N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Polymerase/histidinol phosphatase N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Anthranilate synthase component I N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Ribosomal RNA adenine methylase transferase N-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Aminoacyl-transfer RNA synthetases class-II family profile
Schiff-base intermediate with acetaldehyde
Release factor glutamine methyltransferase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Global transcriptional regulator CodY C-terminal
Global transcriptional regulator CodY N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Sporulation transcription regulator WhiA N-terminal
Shikimate dehydrogenase substrate binding N-terminal
DNA-directed DNA polymerase family A palm
Ribose-phosphate pyrophosphokinase N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
DNA processing protein A sterile alpha motif
Peptidase M1 membrane alanine aminopeptidase
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Thiamin pyrophosphokinase thiamin-binding
Aspartate/homoserine dehydrogenase NAD-binding
DNA mismatch repair proteins mutS family
Small ribosomal subunit protein uS4 N-terminal
Tryptophan synthase beta chain-like PALP
Penicillin-binding protein transpeptidase
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Glucan-binding protein C/Surface antigen I/II V-domain
Interaction with polymerase core subunit RpoC
Carbamoyl-phosphate synthase small subunit N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Gram-positive cocci surface proteins LPxTG
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
2,4-diaminopentanoate dehydrogenase C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Large ribosomal subunit protein uL15/eL18
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Phosphocysteine intermediate; for EIIB activity
Glycosyl transferase family 3 N-terminal
tRNA pseudouridylate synthase B C-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Bacterial type II secretion system protein E
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Helicase superfamily 3 single-stranded DNA/RNA virus
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cysteine sulfenic acid (-SOH) intermediate
Plays an important role in substrate specificity
Cell envelope-related transcriptional attenuator
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
NIF system FeS cluster assembly NifU N-terminal
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
BAAT/Acyl-CoA thioester hydrolase C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Translation elongation factor P/YeiP central
O-(3'-phospho-DNA)-tyrosine intermediate
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
ABC transporter substrate-binding protein PnrA-like
Large ribosomal subunit protein uL6 alpha-beta
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
Transcriptional coactivator p15 (PC4) C-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Restriction endonuclease type II DpnII-like
Regulator of chromosome segregation-like C-terminal
X-Prolyl dipeptidyl aminopeptidase PepX N-terminal
Cation-transporting P-type ATPase N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Prokaryotic-type class I peptide chain release factors
Alpha-D-phosphohexomutase alpha/beta/alpha
ATP synthase F1 complex delta/epsilon subunit N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Replication initiation protein-like C-terminal
Rolling Circle replication initiation protein N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
DNA replication/recombination mediator RecO N-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
Alanyl-transfer RNA synthetases family profile
RNA binding; important for wobble base 34 recognition
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
RNA 2-O ribose methyltransferase substrate binding
Single-stranded-DNA-specific exonuclease RecJ C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Pseudouridine synthase I TruA alpha/beta
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Tellurite resistance methyltransferase TehB-like
SUF system FeS cluster assembly SufBD N-terminal
CobB/CobQ-like glutamine amidotransferase
DNA/pantothenate metabolism flavoprotein C-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Peptide methionine sulphoxide reductase MsrA
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Phosphomannose isomerase type I catalytic
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Involved in allosteric activation by GTP
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
Important for interaction with partner proteins
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Membrane insertase YidC/Oxa/ALB C-terminal
Cobalamin-independent methionine synthase MetE N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
O-(5'-phospho-DNA)-tyrosine intermediate
Bacterial bifunctional deaminase-reductase C-terminal
Phosphotransferase system enzyme I N-terminal
Major facilitator superfamily (MFS) profile
RND efflux pump membrane fusion protein barrel-sandwich
Chromosomal replication initiator DnaA C-terminal
Ionotropic glutamate receptor C-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Phosphatidylglycerol lysyltransferase C-terminal
Type II restriction enzyme and methyltransferase RM.Eco57I-like
S-adenosylmethionine-dependent methyltransferase
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Exonuclease VII large subunit C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Large ribosomal subunit protein uL2 C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
ABC-type glycine betaine transport system substrate-binding
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
YbaK/aminoacyl-tRNA synthetase-associated
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding