Aminoacyl-transfer RNA synthetases class-II family profile
Aminoacyl-tRNA synthetase class I anticodon-binding
Important for guanine/8-oxoguanine distinction
Small zinc finger protein HVO-2753-like zinc-binding pocket
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Polysaccharide biosynthesis protein C-terminal
RNA polymerase subunit H/Rpb5 C-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
Glutamate synthase alpha subunit C-terminal
TATA box binding protein associated factor (TAF) histone-like fold
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Inosine monophosphate cyclohydrolase-like
Polymerase/histidinol phosphatase N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Large ribosomal subunit protein uL2 C-terminal
Pyruvoyl-dependent arginine decarboxylase subunit alpha
Pyruvoyl-dependent arginine decarboxylase subunit beta
Pseudouridine synthase I TruA alpha/beta
Solute-binding protein family 3/N-terminal
Phosphoadenosine phosphosulphate reductase
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Thiamine pyrophosphate enzyme TPP-binding
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Small ribosomal subunit protein uS15 N-terminal
Glycosyl transferase family 3 N-terminal
Aldehyde ferredoxin oxidoreductase N-terminal
Formylmethanofuran dehydrogenase subunit E
Glycosyltransferase subfamily 4-like N-terminal
Water stress and hypersensitive response
SAM-dependent methyltransferase TRM5/TYW2-type
Schiff-base intermediate with dihydroxyacetone-P
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Tryptophan synthase beta chain-like PALP
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Glycoside hydrolase family 57 N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Mannose-6-phosphate isomerase type II C-terminal
Alanyl-transfer RNA synthetases family profile
Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
CobB/CobQ-like glutamine amidotransferase
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Probable transposase IS891/IS1136/IS1341
Carbamoyl-phosphate synthase small subunit N-terminal
Large ribosomal subunit protein uL15/eL18
6-hydroxymethylpterin diphosphokinase MptE-like
Could be important to modulate the pK values of the two catalytic cysteine residues
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
S-adenosyl-L-homocysteine hydrolase NAD binding
DNA-directed RNA polymerase subunit 2 hybrid-binding
Plays an important role in substrate specificity
Removed in mature form; by autocatalysis
Methyl-coenzyme M reductase alpha subunit C-terminal
Methyl-coenzyme M reductase alpha subunit N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Transcription factor NikR nickel binding C-terminal
Aspartate/homoserine dehydrogenase NAD-binding
May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate
Translation elongation factor IF5A C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Methyl-coenzyme M reductase beta subunit C-terminal
Methyl-coenzyme M reductase beta subunit N-terminal
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Prepilin type IV endopeptidase peptidase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Large ribosomal subunit protein uL10-like insertion
Spo11/DNA topoisomerase VI subunit A N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal
RNase L inhibitor RLI-like possible metal-binding
DNA polymerase II large subunit DP2 N-terminal
Na+/H+ antiporter MnhB subunit-related protein
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Ribosome maturation protein SDO1/SBDS C-terminal
Ribosome maturation protein SDO1/SBDS N-terminal
Ribosome maturation protein SDO1/SBDS central
Ribosomal RNA adenine methylase transferase N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Pyrimidine nucleoside phosphorylase C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
RNA 3'-terminal phosphate cyclase insert
Thymidylate synthase/dCMP hydroxymethylase
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Major facilitator superfamily (MFS) profile
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Cation-transporting P-type ATPase N-terminal
Non-canonical purine NTP phosphatase/PRRC1
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Cysteine sulfenic acid (-SOH) intermediate
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Interchain (with Cys-217); in linked form
Interchain (with Cys-51); in linked form
60S ribosome subunit biogenesis protein NIP7 pre-PUA
Increases nucleophilicity of active site Cys
Phosphatidic acid phosphatase type 2/haloperoxidase
Large ribosomal subunit protein uL6 alpha-beta
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Dihydroneopterin aldolase MtpD C-terminal
H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase C-terminal
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr C-terminal
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr N-terminal
Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal
Coenzyme F420 hydrogenase/dehydrogenase beta subunit N-terminal
Transcription factor CBF/NF-Y/archaeal histone
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Tetrahydromethanopterin S-methyltransferase F subunit
Dinitrogenase iron-molybdenum cofactor biosynthesis
Damage-control phosphatase ARMT1-like metal-binding
Glycosyl transferase family 28 C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Pyridoxamine 5'-phosphate oxidase putative
Shikimate dehydrogenase substrate binding N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Small ribosomal subunit protein uS4 N-terminal
Survival protein SurE-like phosphatase/nucleotidase
CO dehydrogenase/acetyl-CoA synthase complex beta subunit C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal