Major facilitator superfamily (MFS) profile
BREX system Lon protease-like BrxL N-terminal
Homogentisate 1,2-dioxygenase C-terminal
Tetracyclin repressor-like C-terminal group 31
S-adenosyl-L-homocysteine hydrolase NAD binding
6-phosphogluconate dehydrogenase C-terminal
Tryptophan synthase beta chain-like PALP
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
Phosphodiester glycosidase domain-containing protein
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Gram-positive cocci surface proteins LPxTG domain-containing protein
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Glycosyltransferase subfamily 4-like N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Leucine-binding protein domain-containing protein
O-(3'-phospho-DNA)-tyrosine intermediate
Sporulation stage II protein D amidase enhancer LytB N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Activator of Hsp90 ATPase homologue 1-like C-terminal
Penicillin-binding protein transpeptidase
Alpha-D-phosphohexomutase alpha/beta/alpha
Bacterial type II secretion system protein E
Peptidase M1 membrane alanine aminopeptidase
RNA polymerase sigma factor 70 region 4 type 2
Peptidase M43 pregnancy-associated plasma-A
Exonuclease VII large subunit C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
RNA 2-O ribose methyltransferase substrate binding
Small ribosomal subunit protein uS4 N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Bacterial bifunctional deaminase-reductase C-terminal
Peptide methionine sulphoxide reductase MsrA
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Transcription regulator AsnC/Lrp ligand binding
FAD-dependent oxidoreductase 2 FAD binding
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
ATP synthase F1 complex delta/epsilon subunit N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Polysaccharide biosynthesis protein C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Thymidylate synthase/dCMP hydroxymethylase
Glycosyl transferase family 28 C-terminal
Polymerase/histidinol phosphatase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Polysaccharide chain length determinant N-terminal
Putative Flp pilus-assembly TadG-like N-terminal
Proton acceptor; for glutaminase activity
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Subtilisin-like protease fibronectin type-III
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Chromosomal replication initiator DnaA C-terminal
Bacterial spore germination immunoglobulin-like
Cell envelope-related transcriptional attenuator
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Sodium/calcium exchanger membrane region
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Cytochrome bc1 complex Rieske iron-sulfur subunit
Nitrite/Sulfite reductase ferredoxin-like
Glycine cleavage T-protein C-terminal barrel
Heat-inducible transcription repressor HrcA C-terminal
Adaptive response protein AidB N-terminal
Glycosyl transferase family 3 N-terminal
Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family protein
YbaK/aminoacyl-tRNA synthetase-associated
Ribosomal RNA adenine methylase transferase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Carbamoyl-phosphate synthase small subunit N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Shikimate dehydrogenase substrate binding N-terminal
Sporulation transcription regulator WhiA N-terminal
Copper type II ascorbate-dependent monooxygenase C-terminal
Carbohydrate-binding domain-containing protein
Could play a key role in the communication between the regulatory and the substrate sites
Alpha-glycerophosphate oxidase C-terminal
Acetyl-CoA hydrolase/transferase C-terminal
Phosphoadenosine phosphosulphate reductase
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
EfeO-type cupredoxin-like domain-containing protein
Mannose-6-phosphate isomerase type II C-terminal
Prenyltransferase and squalene oxidase repeat protein
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Cation-transporting P-type ATPase N-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
O-(5'-phospho-DNA)-tyrosine intermediate
Pyruvate phosphate dikinase AMP/ATP-binding
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Molybdopterin cofactor biosynthesis C (MoaC)
Cytochrome C biogenesis protein transmembrane
Pyruvate dehydrogenase E1 component middle
Threonine/serine exporter-like N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Alanyl-transfer RNA synthetases family profile
Iron dependent repressor metal binding and dimerisation
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Pyridoxamine 5'-phosphate oxidase putative
Cell wall-active antibiotics response LiaF-like C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Butirosin biosynthesis protein H N-terminal
Cytochrome b/b6 N-terminal region profile
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Glyoxalase/fosfomycin resistance/dioxygenase
Alpha/beta hydrolase domain-containing protein
Phospholipase D-like domain-containing protein
Schiff-base intermediate with D-ribose 5-phosphate
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Methylguanine DNA methyltransferase ribonuclease-like
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
PhoD-like phosphatase metallophosphatase
Helix-hairpin-helix DNA-binding motif class 1
CobB/CobQ-like glutamine amidotransferase
Bacterial extracellular solute-binding protein
Inner membrane protein YgaP-like transmembrane
Peptidoglycan recognition protein family
Gly-cisPro motif, important for rejection of L-amino acids
Myo-inositol-1-phosphate synthase GAPDH-like
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Polysaccharide biosynthesis protein CapD-like
Release factor glutamine methyltransferase N-terminal
L-seryl-tRNA selenium transferase N-terminal
Septum formation-related domain-containing protein
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Translation elongation factor P/YeiP central
Ribose-phosphate pyrophosphokinase N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Prokaryotic-type class I peptide chain release factors
Glycosyltransferase family 28 N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
DNA replication/recombination mediator RecO N-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
NIF system FeS cluster assembly NifU N-terminal
DNA-directed DNA polymerase family A palm
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Fibronectin type-III domain-containing protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Transglycosylase SLT domain-containing protein
ABC-type glycine betaine transport system substrate-binding
General stress protein FMN-binding split barrel
Large ribosomal subunit protein uL15/eL18
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
NAD(P) transhydrogenase alpha subunit C-terminal
Essential for prephenate dehydratase activity
SUF system FeS cluster assembly SufBD N-terminal
ABC transporter substrate-binding protein PnrA-like
Prepilin type IV endopeptidase peptidase
Peptidase M15C domain-containing protein
Sodium symporter small subunit predicted
Membrane insertase YidC/Oxa/ALB C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Glucose/Sorbosone dehydrogenase domain-containing protein
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Histidine-specific methyltransferase SAM-dependent
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Putative regulatory protein FmdB Zinc ribbon
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Type II restriction enzyme and methyltransferase RM.Eco57I-like