Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
DnaJ homologue subfamily C member 28 conserved
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Beta-hexosaminidase bacterial type N-terminal
Major facilitator superfamily (MFS) profile
O-(5'-phospho-DNA)-tyrosine intermediate
Alanyl-transfer RNA synthetases family profile
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Glycoside hydrolase family 42 N-terminal
Interaction with polymerase core subunit RpoC
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Myo-inositol-1-phosphate synthase GAPDH-like
ATP synthase F1 complex delta/epsilon subunit N-terminal
MucB/RseB N-terminal domain-containing protein
Glycosyltransferase subfamily 4-like N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Solute-binding protein family 3/N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Gram-positive cocci surface proteins LPxTG
Gram-positive cocci surface proteins LPxTG domain-containing protein
Prokaryotic-type class I peptide chain release factors
Phosphatidate phosphatase APP1 catalytic
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Removed in mature form; by autocatalysis
Penicillin-binding protein transpeptidase
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Peptide methionine sulphoxide reductase MsrA
RNA 2-O ribose methyltransferase substrate binding
Resolvase/invertase-type recombinase catalytic
Phosphocysteine intermediate; for EIIB activity
Peptidase S9 prolyl oligopeptidase catalytic
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
6-phosphogluconate dehydrogenase NADP-binding
Reversibly protonated during proton transport
Bacterial bifunctional deaminase-reductase C-terminal
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Tryptophan synthase beta chain-like PALP
ABC-type glycine betaine transport system substrate-binding
Important for substrate specificity; cannot use PPi as phosphoryl donor
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
YbaK/aminoacyl-tRNA synthetase-associated
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Pyrroline-5-carboxylate reductase catalytic N-terminal
Polymerase/histidinol phosphatase N-terminal
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Cell envelope-related transcriptional attenuator
Anthranilate synthase component I N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Could be important to modulate the pK values of the two catalytic cysteine residues
Glucosamine/galactosamine-6-phosphate isomerase
Membrane insertase YidC/Oxa/ALB C-terminal
DNA replication/recombination mediator RecO N-terminal
Bacterial transcription activator effector binding
Large ribosomal subunit protein uL6 alpha-beta
Acyltransferase MbtK/IucB-like conserved
Threonine/serine exporter-like N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-121)
Phosphatidic acid phosphatase type 2/haloperoxidase
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Release factor glutamine methyltransferase N-terminal
Putative regulatory protein FmdB Zinc ribbon
Large ribosomal subunit protein uL2 C-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
NADH:ubiquinone oxidoreductase-like 20kDa subunit
ABC transporter substrate-binding protein PnrA-like
Glutathionylspermidine synthase pre-ATP-grasp-like
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Choice-of-anchor A domain-containing protein
Proton acceptor; for glutaminase activity
RNA polymerase sigma factor 70 region 4 type 2
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Chromosomal replication initiator DnaA C-terminal
Ribosome maturation factor RimP N-terminal
Peptidoglycan recognition protein family
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Activator of Hsp90 ATPase homologue 1-like C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Alpha-glycerophosphate oxidase C-terminal
Endonuclease/exonuclease/phosphatase domain-containing protein
Translation elongation factor P/YeiP central
Trigger factor ribosome-binding bacterial
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
NIF system FeS cluster assembly NifU N-terminal
Lactate utilization protein B C-terminal
Transcription regulator AsnC/Lrp ligand binding
Large ribosomal subunit protein uL30-like ferredoxin-like fold
DNA topoisomerase I catalytic core eukaryotic-type
Heat-inducible transcription repressor HrcA C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Glycoside hydrolase family 31 N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Sodium/calcium exchanger membrane region
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Positions MEP for the nucleophilic attack
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Schiff-base intermediate with acetaldehyde
Bacterial type II secretion system protein E
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Alpha-D-phosphohexomutase alpha/beta/alpha
Cytochrome bc1 complex cytochrome c subunit
Ribosomal RNA adenine methylase transferase N-terminal
Prepilin type IV endopeptidase peptidase
Peptidase M1 membrane alanine aminopeptidase
SUF system FeS cluster assembly SufBD N-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
3-beta hydroxysteroid dehydrogenase/isomerase
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Heme-copper oxidase subunit III family profile
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
6-phosphogluconate dehydrogenase C-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Cation-transporting P-type ATPase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Ribose-phosphate pyrophosphokinase N-terminal
Nitrite/Sulfite reductase ferredoxin-like
O-(3'-phospho-DNA)-tyrosine intermediate
Endoribonuclease L-PSP/chorismate mutase-like
Cytochrome oxidase subunit II copper A binding
Beta-xylosidase C-terminal Concanavalin A-like
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Small ribosomal subunit protein uS4 N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Putative oxidoreductase/dehydrogenase Rossmann-like
Pseudouridine synthase I TruA alpha/beta
Gly-cisPro motif, important for rejection of L-amino acids
Glycerophosphoryl diester phosphodiesterase membrane
Carbohydrate-binding domain-containing protein
Thymidylate synthase/dCMP hydroxymethylase
Schiff-base intermediate with D-ribose 5-phosphate
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Methionyl-tRNA synthetase anticodon-binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Bacterial extracellular solute-binding protein
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Glycine cleavage T-protein C-terminal barrel
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Molybdopterin cofactor biosynthesis C (MoaC)
Shikimate dehydrogenase substrate binding N-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Sporulation transcription regulator WhiA N-terminal
Peptidase propeptide and YPEB domain protein
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Ionotropic glutamate receptor C-terminal
Plays an important role in substrate specificity
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Sporulation stage II protein D amidase enhancer LytB N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Large ribosomal subunit protein uL15/eL18
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Pyrimidine nucleoside phosphorylase C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Phosphomannose isomerase type I catalytic
Cobalamin-independent methionine synthase MetE N-terminal