Polymerase/histidinol phosphatase N-terminal
Prokaryotic-type class I peptide chain release factors
Curli production assembly/transport component CsgG
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
DNA polymerase III subunit delta C-terminal
Subtilisin-like protease fibronectin type-III
Important for substrate binding and specificity
Trigger factor ribosome-binding bacterial
Glycosyltransferase subfamily 4-like N-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
Glycosyl transferase family 3 N-terminal
Proton acceptor; for glutaminase activity
Disulphide bond isomerase DsbC/G N-terminal
Fibronectin type III domain-containing protein
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Carbamoyl-phosphate synthase small subunit N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Pyruvate phosphate dikinase AMP/ATP-binding
Penicillin-binding protein transpeptidase
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Peptidase C-terminal archaeal/bacterial domain-containing protein
Positions MEP for the nucleophilic attack
Aminoacyl-transfer RNA synthetases class-II family profile
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Translocation and assembly module subunit TamA
RND efflux pump membrane fusion protein barrel-sandwich
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
L-seryl-tRNA selenium transferase N-terminal
Right handed beta helix domain-containing protein
Peptidase S9 prolyl oligopeptidase catalytic
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Putative auto-transporter adhesin head GIN
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Key residue in conferring substrate specificity for N-acetyl-L-ornithine versus N-succinyl-L-ornithine
Plays an important role in substrate specificity
PEP-CTERM sorting domain-containing protein
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
TonB-dependent receptor-like beta-barrel
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Major facilitator superfamily (MFS) profile
Pyruvate dehydrogenase E1 component middle
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Bacterial type II secretion system protein E
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Signal transduction histidine kinase internal region
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Sodium/calcium exchanger membrane region
ATP synthase F1 complex delta/epsilon subunit N-terminal
Delta-60 repeat domain-containing protein
Peptidyl-prolyl cis-trans isomerase FKBP-type N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
RNA polymerase sigma factor 70 region 4 type 2
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
ABC-type uncharacterised transport system
Essential for prephenate dehydratase activity
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Anthranilate synthase component I N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Integral membrane protein YccS N-terminal
Polysaccharide biosynthesis protein CapD-like
NAD(P) transhydrogenase alpha subunit C-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Tryptophan synthase beta chain-like PALP
Adaptive response protein AidB N-terminal
Bacterial virulence factor lipase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
TRAP C4-dicarboxylate transport system permease DctM subunit
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Transition state stabilizer; via amide nitrogen
Proteinase inhibitor I42 chagasin domain-containing protein
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Small ribosomal subunit protein uS4 N-terminal
Peptidase M12B domain-containing protein
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
tRNA pseudouridylate synthase B C-terminal
Large ribosomal subunit protein uL6 alpha-beta
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Plays an important role in discriminating NADH against NADPH
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Activator of Hsp90 ATPase homologue 1-like C-terminal
Organic solvent tolerance-like N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Aminoacyl-tRNA synthetase class I anticodon-binding
Major facilitator superfamily associated
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Large ribosomal subunit protein uL15/eL18
Reversibly protonated during proton transport
Nitrite/Sulfite reductase ferredoxin-like
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
DNA-directed DNA polymerase family A palm
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Bacterial bifunctional deaminase-reductase C-terminal
Acyl-CoA dehydrogenase C-terminal bacterial-type
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Helix-hairpin-helix DNA-binding motif class 1
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Important for interaction with partner proteins
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Photosynthesis system II assembly factor Ycf48/Hcf136-like
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Phosphatidic acid phosphatase type 2/haloperoxidase
Biopterin-dependent aromatic amino acid hydroxylase family profile
Chromosomal replication initiator protein DnaA
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Translation elongation factor P/YeiP central
S-adenosylmethionine-dependent methyltransferase
Membrane fusion protein biotin-lipoyl like
Polysaccharide biosynthesis protein C-terminal
Putative regulatory protein FmdB Zinc ribbon
DNA replication/recombination mediator RecO N-terminal
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Bacterial NAD-glutamate dehydrogenase N-terminal
Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein
PHA accumulation regulator DNA-binding N-terminal
Glycine cleavage T-protein C-terminal barrel
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
PsbP C-terminal domain-containing protein
Peptide methionine sulphoxide reductase MsrA
Putative adhesin domain-containing protein
Outer membrane protein OmpA-like transmembrane
Outer membrane protein OmpA-like transmembrane domain-containing protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Outer membrane protein beta-barrel domain-containing protein
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Phosphodiester glycosidase domain-containing protein
Mannose-6-phosphate isomerase type II C-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Ribulose bisphosphate carboxylase small subunit
Outer membrane protein assembly factor BamA
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Membrane insertase YidC/Oxa/ALB C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
NADH:ubiquinone oxidoreductase intermediate-associated protein 30
3-beta hydroxysteroid dehydrogenase/isomerase
Glutathionylspermidine synthase pre-ATP-grasp-like
Urease accessory protein UreH-like transmembrane
Cysteine sulfenic acid (-SOH) intermediate
Interaction with polymerase core subunit RpoC
SUF system FeS cluster assembly SufBD N-terminal
PQQ-binding-like beta-propeller repeat protein
Heme-copper oxidase subunit III family profile
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
CopL family metal-binding regulatory protein
Ysc84 actin-binding domain-containing protein
Type II secretion system protein GspI C-terminal
Prepilin type IV endopeptidase peptidase
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Molybdopterin cofactor biosynthesis C (MoaC)
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
RNA 2-O ribose methyltransferase substrate binding
Solute-binding protein family 3/N-terminal
Diacylglycerol glucosyltransferase N-terminal
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
RNA binding; important for wobble base 34 recognition
O-(3'-phospho-DNA)-tyrosine intermediate
Transglutaminase domain-containing protein
Thymidylate synthase/dCMP hydroxymethylase
Fibronectin type-III domain-containing protein
M6 family metalloprotease domain-containing protein
Chromosomal replication initiator DnaA C-terminal
Arginine decarboxylase C-terminal helical
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
N-end rule aminoacyl transferase C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Lytic transglycosylase superhelical linker
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
Large ribosomal subunit protein uL2 C-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Inosine/uridine-preferring nucleoside hydrolase
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Required for zinc-mediated homotetramerization and catalytic activity
Regulator of nucleoside diphosphate kinase N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Alanyl-transfer RNA synthetases family profile
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Phosphotransferase system enzyme I N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Periplasmic copper-binding protein NosD beta helix
Periplasmic copper-binding protein NosD beta helix domain-containing protein
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Type II secretion system protein GspG C-terminal
Electron transfer via tryptophanyl radical
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Apoptosis regulator Bcl-2 family BH4 domain-containing protein
Release factor glutamine methyltransferase N-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
TRAP transporter TatT component family protein
NIF system FeS cluster assembly NifU C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal