Threonine/serine exporter-like N-terminal
Resolvase/invertase-type recombinase catalytic
FAD-dependent oxidoreductase 2 FAD binding
Glycoside hydrolase family 31 N-terminal
RNA 2-O ribose methyltransferase substrate binding
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Membrane insertase YidC/Oxa/ALB C-terminal
Gram-positive cocci surface proteins LPxTG domain-containing protein
Major facilitator superfamily (MFS) profile
Peptide methionine sulphoxide reductase MsrA
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Cation-transporting P-type ATPase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Tryptophan synthase beta chain-like PALP
Large ribosomal subunit protein uL2 C-terminal
Anthranilate synthase component I N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Aminoacyl-transfer RNA synthetases class-II family profile
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Cell envelope-related transcriptional attenuator
SUF system FeS cluster assembly SufBD N-terminal
Schiff-base intermediate with acetaldehyde
Single-stranded-DNA-specific exonuclease RecJ C-terminal
6-phosphogluconate dehydrogenase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
HicB-like antitoxin of toxin-antitoxin system
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Carbamoyl-phosphate synthase small subunit N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Gly-cisPro motif, important for rejection of L-amino acids
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Ribose-phosphate pyrophosphokinase N-terminal
Penicillin-binding protein transpeptidase
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Signal recognition particle SRP54 helical bundle
ATP synthase F1 complex delta/epsilon subunit N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Type VII secretion system protein EssD-like
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
Polysaccharide chain length determinant N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Peptidase A24A N-terminal domain-containing protein
Alanyl-transfer RNA synthetases family profile
Translation elongation factor P/YeiP central
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Important for beta-aspartyl-AMP intermediate formation
Small ribosomal subunit protein uS4 N-terminal
ABC-type glycine betaine transport system substrate-binding
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Polysaccharide biosynthesis protein C-terminal
Phage conserved hypothetical protein C-terminal
Solute-binding protein family 3/N-terminal
Chromosomal replication initiator DnaA C-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
CRISPR-associated endonuclease Cas9 REC lobe
Polysaccharide biosynthesis protein CapD-like
DNA-directed DNA polymerase family A palm
RNA binding; important for wobble base 34 recognition
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
DNA replication/recombination mediator RecO N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Choloylglycine hydrolase/NAAA C-terminal
Involved in allosteric activation by GTP
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Exonuclease VII large subunit C-terminal
Chromosomal replication initiator protein DnaA
Pseudouridine synthase I TruA alpha/beta
Lysidine-tRNA(Ile) synthetase C-terminal
Replication initiator protein A C-terminal
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
3-beta hydroxysteroid dehydrogenase/isomerase
Gram-positive cocci surface proteins LPxTG
X-Prolyl dipeptidyl aminopeptidase PepX N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Putative host cell surface-exposed lipoprotein Ltp-like HTH region
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
tRNA pseudouridylate synthase B C-terminal
CobB/CobQ-like glutamine amidotransferase
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glycosyltransferase subfamily 4-like N-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Release factor glutamine methyltransferase N-terminal
Nicking enzyme C-terminal middle helical
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Peptidase M1 membrane alanine aminopeptidase
Glycosyl hydrolase family 30 beta sandwich
Prokaryotic-type class I peptide chain release factors
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
O-(3'-phospho-DNA)-tyrosine intermediate
NIF system FeS cluster assembly NifU N-terminal
Sporulation transcription regulator WhiA N-terminal
Transposase IS116/IS110/IS902 C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Restriction system protein Mrr-like N-terminal
Important for interaction with partner proteins
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Ionotropic glutamate receptor C-terminal
Glycosyl transferase family 3 N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Polymerase/histidinol phosphatase N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transposase IS204/IS1001/IS1096/IS1165 helix-turn-helix
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
Signal transduction histidine kinase 5TM receptor LytS transmembrane region
Signal transduction histidine kinase internal region
Phosphatidic acid phosphatase type 2/haloperoxidase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
DNA-directed RNA polymerase RpoA/D/Rpb3-type
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
5-glutamyl coenzyme A thioester intermediate
Terminase large subunit-like endonuclease
Plays an important role in substrate specificity
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Gram-positive pilin subunit D1 N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Phosphotransferase system enzyme I N-terminal
Helix-turn-helix conjugative transposon-like
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
N6 adenine-specific DNA methyltransferase N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Conserved virulence factor B-like winged helix
Large ribosomal subunit protein uL15/eL18
Phosphocysteine intermediate; for EIIB activity
Reversibly protonated during proton transport
Type I restriction modification DNA specificity
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Cobalamin-independent methionine synthase MetE N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Bacterial bifunctional deaminase-reductase C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Thymidylate synthase/dCMP hydroxymethylase
Regulator of chromosome segregation-like C-terminal
Protein G-related albumin-binding (GA) module
SGNH hydrolase-type esterase domain-containing protein
NAD(P) transhydrogenase alpha subunit C-terminal