Major facilitator superfamily (MFS) profile
DNA-directed DNA polymerase family A palm
Anthranilate synthase component I N-terminal
Solute-binding protein family 3/N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
O-(5'-phospho-DNA)-tyrosine intermediate
Cell envelope-related transcriptional attenuator
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Trigger factor ribosome-binding bacterial
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Septum formation-related domain-containing protein
Large ribosomal subunit protein uL2 C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
SUF system FeS cluster assembly SufBD N-terminal
Phosphotransferase system enzyme I N-terminal
Prepilin type IV endopeptidase peptidase
Prokaryotic-type class I peptide chain release factors
RNA 2-O ribose methyltransferase substrate binding
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Alpha-D-phosphohexomutase alpha/beta/alpha
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Membrane insertase YidC/Oxa/ALB C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Ribosomal RNA small subunit methyltransferase E methyltransferase
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Activator of Hsp90 ATPase homologue 1-like C-terminal
Cysteine sulfenic acid (-SOH) intermediate
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cytochrome b/b6 N-terminal region profile
Phosphocysteine intermediate; for EIIB activity
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
DNA primase/polymerase bifunctional N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Protocatechuate 3,4-dioxygenase beta subunit N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Solute-binding protein family 3/N-terminal domain-containing protein
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Essential for prephenate dehydratase activity
Transposase IS204/IS1001/IS1096/IS1165 DDE
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Bacterial type II secretion system protein E
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Sodium/calcium exchanger membrane region
Aminoacyl-transfer RNA synthetases class-II family profile
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Ribose-phosphate pyrophosphokinase N-terminal
Small ribosomal subunit protein uS4 N-terminal
Glycosyl transferase family 3 N-terminal
Glycosyltransferase subfamily 4-like N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
NIF system FeS cluster assembly NifU N-terminal
RNA polymerase sigma factor 70 region 4 type 2
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Phosphomannose isomerase type I catalytic
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Polymerase/histidinol phosphatase N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Inosine/uridine-preferring nucleoside hydrolase
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Phenol hydroxylase C-terminal dimerisation
Bacterial transcription activator effector binding
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Na+/H+ antiporter MnhB subunit-related protein
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
ATP-dependent DNA helicase RecG C-terminal
Ionotropic glutamate receptor C-terminal
Resuscitation-promoting factor Rpf1 C-terminal
Resuscitation-promoting factor core lysozyme-like
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
RNA binding; important for wobble base 34 recognition
Plays an important role in substrate specificity
Ribosomal RNA adenine methylase transferase N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Schiff-base intermediate with D-ribose 5-phosphate
ABC-type glycine betaine transport system substrate-binding
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Molybdopterin cofactor biosynthesis C (MoaC)
NADH:flavin oxidoreductase/NADH oxidase N-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Metal ABC transporter substrate-binding protein
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Periplasmic binding protein domain-containing protein
Reversibly protonated during proton transport
L,D-transpeptidase catalytic domain-containing protein
CobB/CobQ-like glutamine amidotransferase
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Sigma 54 modulation/S30EA ribosomal protein C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Could play a key role in the communication between the regulatory and the substrate sites
Chromosomal replication initiator DnaA C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Glucose-methanol-choline oxidoreductase N-terminal
Type I restriction modification DNA specificity
O-(3'-phospho-DNA)-tyrosine intermediate
4'-phosphopantetheinyl transferase N-terminal
Peptidase M1 membrane alanine aminopeptidase
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Glucosamine/galactosamine-6-phosphate isomerase
Alanyl-transfer RNA synthetases family profile
6-phosphogluconate dehydrogenase C-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Tryptophan synthase beta chain-like PALP
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Resolvase/invertase-type recombinase catalytic
Glycine cleavage T-protein C-terminal barrel
Carbamoyl-phosphate synthase small subunit N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Bacterial bifunctional deaminase-reductase C-terminal
Release factor glutamine methyltransferase N-terminal
ABC transporter substrate-binding protein
Heat-inducible transcription repressor HrcA C-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
DNA replication/recombination mediator RecO N-terminal
Ribosome maturation factor RimP N-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Type II secretion system protein GspF domain-containing protein
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Fe/B12 periplasmic-binding domain-containing protein
Peptidase S9 prolyl oligopeptidase catalytic
Aspartate/homoserine dehydrogenase NAD-binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Transglycosylase SLT domain-containing protein
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Positions MEP for the nucleophilic attack
Sporulation transcription regulator WhiA N-terminal
Siderophore-interacting protein C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Important for beta-aspartyl-AMP intermediate formation
Interaction with polymerase core subunit RpoC
Penicillin-binding protein transpeptidase
Type III restriction enzyme C-terminal endonuclease
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Large ribosomal subunit protein uL6 alpha-beta
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Methylguanine DNA methyltransferase ribonuclease-like
Nitrite/Sulfite reductase ferredoxin-like
Exonuclease VII large subunit C-terminal
Thymidylate synthase/dCMP hydroxymethylase
Putative host cell surface-exposed lipoprotein Ltp-like HTH region
Pyruvate dehydrogenase E1 component middle
Peptide methionine sulphoxide reductase MsrA
Phosphoribosylformylglycinamidine synthase linker
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Translation elongation factor P/YeiP central
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Large ribosomal subunit protein uL15/eL18
Endoribonuclease L-PSP/chorismate mutase-like
Involved in ionization of N3 of dUMP, leading to its activation