O-(3'-phospho-DNA)-tyrosine intermediate
Important for interaction with partner proteins
Pyridoxamine 5'-phosphate oxidase putative
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Translation elongation factor P/YeiP central
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
RND efflux pump membrane fusion protein barrel-sandwich
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
TonB-dependent receptor-like beta-barrel
Polymerase/histidinol phosphatase N-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Major facilitator superfamily (MFS) profile
Saccharopine dehydrogenase-like C-terminal
Cytochrome C biogenesis protein transmembrane
Thiol:disulfide interchange protein DsbD N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Superoxide dismutase copper/zinc binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Glycosyl transferase family 28 C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Tryptophan synthase beta chain-like PALP
Gamma-glutamylcyclotransferase AIG2-like
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Prokaryotic-type class I peptide chain release factors
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Aminoacyl-transfer RNA synthetases class-II family profile
Beta-lactamase hydrolase-like protein phosphatase-like
Polysaccharide biosynthesis protein C-terminal
Histidine phosphotransferase ChpT C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Large ribosomal subunit protein uL15/eL18
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Cation-transporting P-type ATPase N-terminal
YMGG-like Gly-zipper domain-containing protein
DNA-directed DNA polymerase family A palm
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Penicillin-binding protein transpeptidase
Pyruvate phosphate dikinase AMP/ATP-binding
tRNA pseudouridylate synthase B C-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Membrane fusion protein biotin-lipoyl like
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
6-phosphogluconate dehydrogenase NADP-binding
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
peptide-methionine (R)-S-oxide reductase
Thymidylate synthase/dCMP hydroxymethylase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Pseudouridine synthase I TruA alpha/beta
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
AraC-type arabinose-binding/dimerisation
Aminoacyl-tRNA synthetase class I anticodon-binding
Peptidase M1 membrane alanine aminopeptidase
Peptide methionine sulphoxide reductase MsrA
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Peptidase S9 prolyl oligopeptidase catalytic
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
Histidine-specific methyltransferase SAM-dependent
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
NADH:ubiquinone oxidoreductase 30kDa subunit
Aromatic-ring-hydroxylating dioxygenase alpha subunit C-terminal
Glycosyl transferase family 3 N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Large ribosomal subunit protein uL2 C-terminal
Interaction with polymerase core subunit RpoC
N-end rule aminoacyl transferase C-terminal
Thiamine pyrophosphate enzyme TPP-binding
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Sialate O-acetylesterase domain-containing protein
Biopterin-dependent aromatic amino acid hydroxylase family profile
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Polysaccharide chain length determinant N-terminal
Reversibly protonated during proton transport
Large ribosomal subunit protein uL6 alpha-beta
SUF system FeS cluster assembly SufBD N-terminal
Extensin-like C-terminal domain-containing protein
Release factor glutamine methyltransferase N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Resolvase/invertase-type recombinase catalytic
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
LPXTG cell wall anchor domain-containing protein
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Nitrite/Sulfite reductase ferredoxin-like
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
RNA binding; important for wobble base 34 recognition
Cytochrome b561 bacterial/Ni-hydrogenase
Cysteine sulfenic acid (-SOH) intermediate
Bacterial type II secretion system protein E
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Restriction endonuclease type II EcoRII C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Signal recognition particle SRP54 helical bundle
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase-like C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Molybdenum cofactor biosynthesis protein F N-terminal
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Plays an important role in substrate specificity
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Heme-copper oxidase subunit III family profile
Cytochrome c-type biogenesis protein CcmF C-terminal
Methionyl-tRNA synthetase anticodon-binding
Heat-inducible transcription repressor HrcA C-terminal
Peptide methionine sulfoxide reductase MsrA
Helix-hairpin-helix DNA-binding motif class 1
Shikimate dehydrogenase substrate binding N-terminal
Prepilin type IV endopeptidase peptidase
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Na+/H+ antiporter MnhB subunit-related protein
Poly-beta-hydroxybutyrate polymerase N-terminal
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Metallo-mystery pair system four-Cys motif protein
Signal transduction histidine kinase subgroup 2 dimerisation and phosphoacceptor
RNA polymerase sigma factor 70 region 4 type 2
Phosphoribosylformylglycinamidine synthase linker
Inner membrane protein YgaP-like transmembrane
Transcription elongation factor GreA/GreB C-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Glycine zipper domain-containing protein
Electron transfer via tryptophanyl radical
Important for beta-aspartyl-AMP intermediate formation
Protein O-mannosyl-transferase C-terminal four TM
Required for zinc-mediated homotetramerization and catalytic activity
Survival protein SurE-like phosphatase/nucleotidase
Sodium/calcium exchanger membrane region
Ribosomal RNA adenine methylase transferase N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Cobaltochelatase subunit CobS N-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glycosyltransferase subfamily 4-like N-terminal
TonB-dependent receptor-like beta-barrel domain-containing protein
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
Cytochrome c oxidase subunit IV bacterial aa3 type
Chromosomal replication initiator DnaA C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Anthranilate synthase component I N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Autotransporter domain-containing protein
Flagella basal body P-ring formation protein FlgA C-terminal
PHA accumulation regulator DNA-binding N-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Membrane insertase YidC/Oxa/ALB C-terminal
Glycosyltransferase family 28 N-terminal
Outer membrane protein assembly factor BamA
Outer membrane protein beta-barrel domain-containing protein
Neutral/alkaline non-lysosomal ceramidase N-terminal
Putative glycogen debranching enzyme N-terminal
DNA replication/recombination mediator RecO N-terminal
Beta-xylosidase C-terminal Concanavalin A-like
Polysaccharide biosynthesis protein CapD-like
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
RNA 2-O ribose methyltransferase substrate binding
TonB C-terminal domain-containing protein
Small ribosomal subunit protein uS4 N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Alanyl-transfer RNA synthetases family profile
Organic solvent tolerance-like N-terminal
Glycine cleavage T-protein C-terminal barrel
Putative oxidoreductase/dehydrogenase Rossmann-like
Essential for prephenate dehydratase activity
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Transcription elongation factor GreA/GreB N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Tetrahydrodipicolinate-N-succinyltransferase chain A
Outer membrane protein assembly factor BamD
Activator of Hsp90 ATPase homologue 1-like C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Thioredoxin-like fold domain-containing protein
Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein