Major facilitator superfamily (MFS) profile
Mycothiol-dependent maleylpyruvate isomerase metal-binding
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Cell envelope-related transcriptional attenuator
6-phosphogluconate dehydrogenase C-terminal
Alanyl-transfer RNA synthetases family profile
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Penicillin-binding protein transpeptidase
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Plays an important role in substrate specificity
Alpha-glycerophosphate oxidase C-terminal
Transposase IS116/IS110/IS902 C-terminal
Signal recognition particle SRP54 helical bundle
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
RNA polymerase sigma factor 70 region 4 type 2
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
6-phosphogluconate dehydrogenase NADP-binding
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Positions MEP for the nucleophilic attack
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
UDP-glucose/GDP-mannose dehydrogenase C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
DNA primase/polymerase bifunctional N-terminal
Peptidase M1 membrane alanine aminopeptidase
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Mandelate racemase/muconate lactonizing enzyme C-terminal
DNA-directed DNA polymerase family A palm
Pseudouridine synthase I TruA alpha/beta
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Pyrroline-5-carboxylate reductase catalytic N-terminal
Glycosyltransferase family 28 N-terminal
Microcin J25-processing protein McjB C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Inosine/uridine-preferring nucleoside hydrolase
Large ribosomal subunit protein uL6 alpha-beta
Aminoacyl-transfer RNA synthetases class-II family profile
Styrene monooxygenase StyA putative substrate binding
Beta-hexosaminidase bacterial type N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Cytochrome C biogenesis protein transmembrane
Alpha-D-phosphohexomutase alpha/beta/alpha
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Lactate utilization protein B C-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Peptidase S9 prolyl oligopeptidase catalytic
Essential for prephenate dehydratase activity
Pyrimidine nucleoside phosphorylase C-terminal
Erythromycin biosynthesis protein CIII-like central
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
NADH:ubiquinone oxidoreductase 30kDa subunit
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Putative oxidoreductase/dehydrogenase Rossmann-like
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Heat-inducible transcription repressor HrcA C-terminal
SGNH hydrolase-type esterase domain-containing protein
Glycine cleavage T-protein C-terminal barrel
Involved in ionization of N3 of dUMP, leading to its activation
Cytochrome bc1 complex Rieske iron-sulfur subunit
LPXTG cell wall anchor domain-containing protein
Cytochrome b/b6 N-terminal region profile
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Adaptive response protein AidB N-terminal
Polysaccharide lyase 8 N-terminal alpha-helical
Polysaccharide lyase family 8 C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Phosphatidylinositol-specific phospholipase C X
Glucose-methanol-choline oxidoreductase N-terminal
Phosphomannose isomerase type I catalytic
Ribosomal RNA adenine methylase transferase N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
RlpA-like protein double-psi beta-barrel
Important for substrate specificity; cannot use PPi as phosphoryl donor
Phosphatidic acid phosphatase type 2/haloperoxidase
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Prokaryotic-type class I peptide chain release factors
Transcription regulator AsnC/Lrp ligand binding
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Polymerase/histidinol phosphatase N-terminal
Cytochrome oxidase subunit II copper A binding
Gram-positive cocci surface proteins LPxTG
Tryptophan synthase beta chain-like PALP
PhoD-like phosphatase metallophosphatase
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Quercetin 2,3-dioxygenase C-terminal cupin
Important for autoinhibition of adenylyltransferase activity
S-adenosyl-L-homocysteine hydrolase NAD binding
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Pyridoxamine 5'-phosphate oxidase putative
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Glycosyl transferase family 3 N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Bacterial bifunctional deaminase-reductase C-terminal
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
N6 adenine-specific DNA methyltransferase N-terminal
Helix-hairpin-helix DNA-binding motif class 1
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Small ribosomal subunit protein uS4 N-terminal
ABC-type glycine betaine transport system substrate-binding
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Glycosyl transferase family 28 C-terminal
Anthranilate synthase component I N-terminal
Glycoside-hydrolase family GH114 TIM-barrel
Putative regulatory protein FmdB Zinc ribbon
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Interaction with polymerase core subunit RpoC
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Glycoside hydrolase family 42 N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Solute-binding protein family 3/N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Translation elongation factor EFTu/EF1A C-terminal
Large ribosomal subunit protein uL15/eL18
Resolvase/invertase-type recombinase catalytic
DNA replication/recombination mediator RecO N-terminal
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Electron transfer flavoprotein alpha/beta-subunit N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Methionyl-tRNA synthetase anticodon-binding
NIF system FeS cluster assembly NifU N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Butirosin biosynthesis protein H N-terminal
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Ribose-phosphate pyrophosphokinase N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Gamma-glutamylcyclotransferase AIG2-like
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Periplasmic copper-binding protein NosD beta helix
Cation-transporting P-type ATPase N-terminal
Release factor glutamine methyltransferase N-terminal
Probable subtilase-type protease inhibitor
Putative exodeoxyribonuclease 8 PDDEXK-like
Acetylserotonin O-methyltransferase dimerisation
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
N,N-dimethylformamidase beta subunit-like C-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
ABC transporter substrate-binding protein PnrA-like
Streptomyces killer toxin-like beta/gamma crystallin domain-containing protein
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Pyruvate dehydrogenase E1 component middle
Alpha-L-arabinofuranosidase B arabinose-binding
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Carbamoyl-phosphate synthase small subunit N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
RNA 2-O ribose methyltransferase substrate binding
Histidine-specific methyltransferase SAM-dependent
Large ribosomal subunit protein uL2 C-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Acyltransferase MbtK/IucB-like conserved
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Cysteine sulfenic acid (-SOH) intermediate
Protein O-mannosyl-transferase C-terminal four TM
5a,11a-dehydrotetracycline/5a,11a-dehydrooxytetracycline reductase
Translation elongation factor P/YeiP central
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Important for beta-aspartyl-AMP intermediate formation
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Heme-copper oxidase subunit III family profile
ATP-dependent DNA helicase RecG C-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Could be important to modulate the pK values of the two catalytic cysteine residues
Glucosamine/galactosamine-6-phosphate isomerase
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
12-dehydrotetracycline 5-monooxygenase/anhydrotetracycline 6-monooxygenase
Decrease of the ratio between oxytetracycline and tetracycline.
Dramatic change in the product ratio, in which the amount of tetracycline exceeds that of oxytetracycline.
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Schiff-base intermediate with substrate; via topaquinone
Bacterial type II secretion system protein E
DnaJ homologue subfamily C member 28 conserved
Phosphotransferase system enzyme I N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Exonuclease VII large subunit C-terminal
Large ribosomal subunit protein bL12 C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Reversibly protonated during proton transport
SUF system FeS cluster assembly SufBD N-terminal
Glycoside hydrolase family 31 N-terminal
Integral membrane protein YccS N-terminal
Electron transfer via tryptophanyl radical
N-acetylneuraminic acid synthase N-terminal
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Cell wall-active antibiotics response LiaF-like C-terminal
Proton acceptor; for glutaminase activity
Removed in mature form; by autocatalysis
Peptide methionine sulphoxide reductase MsrA
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Superoxide dismutase copper/zinc binding
Large ribosomal subunit protein bL12 oligomerization
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Phosphoribosylformylglycinamidine synthase linker
Endoribonuclease L-PSP/chorismate mutase-like
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Sporulation transcription regulator WhiA N-terminal
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
Type VII secretion system protein EssD-like
Peptidoglycan recognition protein family
Gly-cisPro motif, important for rejection of L-amino acids
Cobalamin-independent methionine synthase MetE N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Thiopeptide-type bacteriocin biosynthesis
Schiff-base intermediate with D-ribose 5-phosphate
Lysyl-tRNA synthetase N-terminal transmembrane region
Phosphatidylglycerol lysyltransferase C-terminal
Na+/H+ antiporter MnhB subunit-related protein
Cytochrome bc1 complex cytochrome c subunit