Major facilitator superfamily (MFS) profile
Anthranilate synthase component I N-terminal
Glycine cleavage T-protein C-terminal barrel
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Membrane fusion protein biotin-lipoyl like
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Aminoacyl-transfer RNA synthetases class-II family profile
ABC-type glycine betaine transport system substrate-binding
Poly-beta-hydroxybutyrate polymerase N-terminal
Penicillin-binding protein transpeptidase
Large ribosomal subunit protein uL6 alpha-beta
Survival protein SurE-like phosphatase/nucleotidase
Invasion associated locus B family protein
Prokaryotic-type class I peptide chain release factors
Plays an important role in substrate specificity
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Outer membrane protein assembly factor BamA
RNA polymerase sigma factor 70 region 4 type 2
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
DNA polymerase III subunit delta C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Lysidine-tRNA(Ile) synthetase C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
SUF system FeS cluster assembly SufBD N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Solute-binding protein family 3/N-terminal
Interaction with polymerase core subunit RpoC
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
RND efflux pump membrane fusion protein barrel-sandwich
Large ribosomal subunit protein uL15/eL18
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
RNA binding; important for wobble base 34 recognition
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Molybdopterin cofactor biosynthesis C (MoaC)
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Peptidase S9 prolyl oligopeptidase catalytic
TRAP C4-dicarboxylate transport system permease DctM subunit
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Tryptophan synthase beta chain-like PALP
Reversibly protonated during proton transport
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Thymidylate synthase/dCMP hydroxymethylase
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Na+/H+ antiporter MnhB subunit-related protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Alanyl-transfer RNA synthetases family profile
DNA replication/recombination mediator RecO N-terminal
TonB-dependent receptor-like beta-barrel
High potential iron-sulfur proteins family profile
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Translation elongation factor P/YeiP central
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Pseudouridine synthase I TruA alpha/beta
Phosphatidic acid phosphatase type 2/haloperoxidase
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Translocation and assembly module subunit TamA
NADH:ubiquinone oxidoreductase 30kDa subunit
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
DNA-directed RNA polymerase RpoA/D/Rpb3-type
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
DNA mismatch repair proteins mutS family
Polysaccharide biosynthesis protein C-terminal
Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding
Outer membrane lipoprotein-sorting protein
Glucosamine/galactosamine-6-phosphate isomerase
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Gly-cisPro motif, important for rejection of L-amino acids
Prepilin type IV endopeptidase peptidase
RNA methyltransferase SpoU/TrmH type C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Sugar fermentation stimulation protein C-terminal
Organic solvent tolerance-like N-terminal
High-affinity zinc uptake system protein ZnuA
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
DNA-directed DNA polymerase family A palm
Glycosyltransferase subfamily 4-like N-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Putative regulatory protein FmdB Zinc ribbon
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
O-(3'-phospho-DNA)-tyrosine intermediate
Alpha-glycerophosphate oxidase C-terminal
RNA 2-O ribose methyltransferase substrate binding
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Heme-copper oxidase subunit III family profile
Could be important to modulate the pK values of the two catalytic cysteine residues
Carbamoyl-phosphate synthase small subunit N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Glycosyl transferase family 3 N-terminal
ABC-type transport auxiliary lipoprotein component domain-containing protein
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Essential for prephenate dehydratase activity
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Membrane insertase YidC/Oxa/ALB C-terminal
Outer-membrane lipoprotein carrier protein
Histidine-specific methyltransferase SAM-dependent
Interacts with tRNA; defines subfamily-specific binding signature
BREX system Lon protease-like BrxL N-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Tetrahydrodipicolinate-N-succinyltransferase chain A
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Important for interaction with partner proteins
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-98)
Cysteine sulfenic acid (-SOH) intermediate
Bacterial type II secretion system protein E
Chromosomal replication initiator DnaA C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Exonuclease VII large subunit C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Small ribosomal subunit protein uS4 N-terminal
Electron transfer via tryptophanyl radical
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Polymerase/histidinol phosphatase N-terminal
Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal
Coenzyme F420 hydrogenase/dehydrogenase beta subunit N-terminal
Sodium symporter small subunit predicted
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Large ribosomal subunit protein uL2 C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Gamma-butyrobetaine hydroxylase-like N-terminal
NIF system FeS cluster assembly NifU N-terminal
Chromosomal replication initiator protein DnaA
Mannose-6-phosphate isomerase type II C-terminal
Polysaccharide biosynthesis protein CapD-like
Proton acceptor; for glutaminase activity
Pyruvate phosphate dikinase AMP/ATP-binding
Sodium/calcium exchanger membrane region
Cation-transporting P-type ATPase N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Inner membrane protein YgaP-like transmembrane
Outer membrane protein beta-barrel domain-containing protein
Important for substrate binding and specificity