Water stress and hypersensitive response
HicB-like antitoxin of toxin-antitoxin system
CRISPR-associated protein Cas6 C-terminal
Large ribosomal subunit protein uL15/eL18
NADH:ubiquinone oxidoreductase 30kDa subunit
Antitoxin Xre/MbcA/ParS-like toxin-binding
Gly-cisPro motif, important for rejection of L-amino acids
Penicillin-binding protein transpeptidase
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Pseudouridine synthase I TruA alpha/beta
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
RND efflux pump membrane fusion protein barrel-sandwich
Polysaccharide biosynthesis protein CapD-like
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Arginine decarboxylase C-terminal helical
N-end rule aminoacyl transferase C-terminal
Glycosyl transferase family 3 N-terminal
Thiamine pyrophosphate enzyme TPP-binding
Membrane fusion protein biotin-lipoyl like
Cytochrome b561 bacterial/Ni-hydrogenase
EfeO-type cupredoxin-like domain-containing protein
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Na+/H+ antiporter MnhB subunit-related protein
Large ribosomal subunit protein uL2 C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Solute-binding protein family 3/N-terminal
Major facilitator superfamily (MFS) profile
SUF system FeS cluster assembly SufBD N-terminal
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Type II secretion system protein GspG C-terminal
Transcription factor NikR nickel binding C-terminal
Interaction with polymerase core subunit RpoC
Menaquinone biosynthesis protein MenD middle
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Urease accessory protein UreH-like transmembrane
Metallo-mystery pair system four-Cys motif protein
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Aminoacyl-transfer RNA synthetases class-II family profile
Survival protein SurE-like phosphatase/nucleotidase
RNA polymerase sigma factor 70 region 4 type 2
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
ATPsynthase alpha/beta subunit N-terminal extension
NIF system FeS cluster assembly NifU N-terminal
Alpha-glycerophosphate oxidase C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
6-phosphogluconate dehydrogenase C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Could play a key role in the communication between the regulatory and the substrate sites
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-96)
Peptide methionine sulphoxide reductase MsrA
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Small ribosomal subunit protein uS4 N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Glucan biosynthesis periplasmic MdoG C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Interchain (with Cys-215); in linked form
Interchain (with Cys-56); in linked form
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
ATP-grasp fold succinyl-CoA synthetase-type
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
7 transmembrane helices usually fused to an inactive transglutaminase
Inactive transglutaminase fused to 7 transmembrane helices
Polysaccharide chain length determinant N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Bacterial type II secretion system protein E
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Flavocytochrome c sulphide dehydrogenase flavin-binding
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Required for dimer formation and molybdate binding
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Cytochrome c7-like domain-containing protein
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone oxidoreductase chain 4 N-terminal
DNA-directed DNA polymerase family A palm
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Putative Flp pilus-assembly TadG-like N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Thiol:disulfide interchange protein DsbD
Acyl-CoA dehydrogenase/oxidase C-terminal
Adaptive response protein AidB N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Schiff-base intermediate with substrate; via pyruvic acid
Alanyl-transfer RNA synthetases family profile
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Type I restriction modification DNA specificity
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Lytic transglycosylase superhelical linker
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Cytochrome c-552/DMSO reductase-like haem-binding
Dicarboxylate transport domain-containing protein
Inner membrane protein YgaP-like transmembrane
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Outer membrane protein assembly factor BamE
Gamma-butyrobetaine hydroxylase-like N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
HupH hydrogenase expression protein C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Sodium symporter small subunit predicted
Cob(I)alamin adenosyltransferase N-terminal
ATP-dependent DNA helicase RecG C-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Pyruvate phosphate dikinase AMP/ATP-binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Tryptophan synthase beta chain-like PALP
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Pyruvate/ketoisovalerate oxidoreductase catalytic
Mannose-6-phosphate isomerase type II C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
O-(3'-phospho-DNA)-tyrosine intermediate
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Signal transduction histidine kinase internal region
Outer membrane lipoprotein-sorting protein
Polymerase/histidinol phosphatase N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Transposase IS116/IS110/IS902 C-terminal
CobB/CobQ-like glutamine amidotransferase
ABC-type transport auxiliary lipoprotein component
ABC-type transport auxiliary lipoprotein component domain-containing protein
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
HPr(Ser) kinase/phosphorylase N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Large ribosomal subunit protein uL6 alpha-beta
Histidine-specific methyltransferase SAM-dependent
Sodium/calcium exchanger membrane region
Major facilitator superfamily associated
Periplasmic nitrate reductase, electron transfer subunit
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Cytochrome c-type biogenesis protein CcmF C-terminal
Glycosyltransferase subfamily 4-like N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
RNA 2-O ribose methyltransferase substrate binding
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Type 4 fimbrial biogenesis protein PilX N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Outer membrane protein assembly factor BamA
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Prokaryotic-type class I peptide chain release factors
Gamma-glutamylcyclotransferase AIG2-like
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
L-seryl-tRNA selenium transferase N-terminal
Ribulose bisphosphate carboxylase small subunit
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
TonB-dependent receptor-like beta-barrel
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Molybdopterin cofactor biosynthesis C (MoaC)
Plays an important role in substrate specificity
Helix-hairpin-helix DNA-binding motif class 1
Carbamoyl-phosphate synthase small subunit N-terminal
Translation elongation factor P/YeiP central
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
S-adenosyl-L-homocysteine hydrolase NAD binding
Fibronectin type III domain-containing protein
Membrane insertase YidC/Oxa/ALB C-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Conserved hypothetical protein CHP02679 N terminus
Regulator of nucleoside diphosphate kinase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Protein-L-isoaspartate O-methyltransferase
Outer-membrane lipoprotein carrier protein
Important for substrate binding and specificity
Cytochrome oxidase subunit II copper A binding
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Peptidase M1 membrane alanine aminopeptidase
Putative regulatory protein FmdB Zinc ribbon
Outer membrane protein beta-barrel domain-containing protein
L-cysteine S-thiosulfotransferase subunit SoxA
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Cytochrome C Planctomycete-type domain-containing protein
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transposase IS204/IS1001/IS1096/IS1165 helix-turn-helix
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
ABC-type glycine betaine transport system substrate-binding
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Contractile injection system tube protein N-terminal
DNA replication/recombination mediator RecO N-terminal
Chromosomal replication initiator DnaA C-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Prepilin type IV endopeptidase peptidase
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Transglycosylase SLT domain-containing protein
Siroheme decarboxylase AsnC-like ligand binding
PHA accumulation regulator DNA-binding N-terminal
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Reversibly protonated during proton transport
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Electron transfer via tryptophanyl radical
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Important for beta-aspartyl-AMP intermediate formation
NIF system FeS cluster assembly NifU C-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Disulphide bond isomerase DsbC/G N-terminal
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Transcription elongation factor GreA/GreB N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Ribosomal RNA adenine methylase transferase N-terminal