NADH:flavin oxidoreductase/NADH oxidase N-terminal
Major facilitator superfamily (MFS) profile
Positions MEP for the nucleophilic attack
Acyl-CoA dehydrogenase/oxidase N-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Tryptophan synthase beta chain-like PALP
Peptidase S9 prolyl oligopeptidase catalytic
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Pseudouridine synthase I TruA alpha/beta
Acyl-CoA dehydrogenase/oxidase C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
RNA 2-O ribose methyltransferase substrate binding
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Proline utilization A proline dehydrogenase N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Pyridoxamine 5'-phosphate oxidase putative
Choloylglycine hydrolase/NAAA C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Thiamine pyrophosphate enzyme TPP-binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
Polysaccharide chain length determinant N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Cysteine sulfenic acid (-SOH) intermediate
TRAP C4-dicarboxylate transport system permease DctM subunit
Flagellar motor switch protein FliN-like C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Interaction with polymerase core subunit RpoC
Mandelate racemase/muconate lactonizing enzyme C-terminal
Putative regulatory protein FmdB Zinc ribbon
O-(phosphoribosyl dephospho-coenzyme A)serine
Bacterial transcription activator effector binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Gly-cisPro motif, important for rejection of L-amino acids
Phosphotransferase system enzyme I N-terminal
Moybdenum cofactor oxidoreductase dimerisation
DNA-directed DNA polymerase family A palm
Cytochrome b561 bacterial/Ni-hydrogenase
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Heme-copper oxidase subunit III family profile
N-sulphoglucosamine sulphohydrolase C-terminal
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Glucose-methanol-choline oxidoreductase N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Activator of Hsp90 ATPase homologue 1-like C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
HicB-like antitoxin of toxin-antitoxin system
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
UDP N-acetylglucosamine O-acyltransferase C-terminal
TonB-dependent receptor-like beta-barrel
Antitoxin Xre/MbcA/ParS-like toxin-binding
Glycosyltransferase subfamily 4-like N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Bacterial bifunctional deaminase-reductase C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Translation elongation factor P/YeiP central
Polymerase/histidinol phosphatase N-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Helix-hairpin-helix DNA-binding motif class 1
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
NIF system FeS cluster assembly NifU N-terminal
Transposase IS204/IS1001/IS1096/IS1165 DDE
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Alpha-glycerophosphate oxidase C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
ABC-type transport auxiliary lipoprotein component
DNA replication/recombination mediator RecO N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Mannose-6-phosphate isomerase type II C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Membrane fusion protein biotin-lipoyl like
Glycine cleavage T-protein C-terminal barrel
Aldehyde oxidase/xanthine dehydrogenase first molybdopterin binding
Aldehyde oxidase/xanthine dehydrogenase second molybdopterin binding
Molybdopterin cofactor biosynthesis C (MoaC)
Yop protein translocation protein D periplasmic
Pyruvate phosphate dikinase AMP/ATP-binding
Survival protein SurE-like phosphatase/nucleotidase
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glycerol-3-phosphate dehydrogenase [NAD(P)+]
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Chromosomal replication initiator DnaA C-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
NADH:ubiquinone oxidoreductase 30kDa subunit
Trimeric autotransporter adhesin YadA-like C-terminal membrane anchor
Trimeric autotransporter adhesin YadA-like head
Trimeric autotransporter adhesin YadA-like stalk
Lysozyme inhibitor LprI N-terminal domain-containing protein
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Haem-binding uptake Tiki superfamily ChaN
Haem-binding uptake Tiki superfamily ChaN domain-containing protein
Alpha-D-phosphohexomutase alpha/beta/alpha
Glucose-methanol-choline oxidoreductase C-terminal
Diacylglycerol glucosyltransferase N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
D-galactarate/Altronate dehydratase C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
tRNA pseudouridylate synthase B C-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Phosphatidic acid phosphatase type 2/haloperoxidase
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Penicillin-binding protein transpeptidase
ABC-type glycine betaine transport system substrate-binding
Acyl-CoA dehydrogenase C-terminal bacterial-type
Important for beta-aspartyl-AMP intermediate formation
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Transcriptional regulator AbiEi antitoxin N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Large ribosomal subunit protein uL2 C-terminal
Outer-membrane lipoprotein carrier protein
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Ribose-phosphate pyrophosphokinase N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
PHA accumulation regulator DNA-binding N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Important for interaction with partner proteins
Type VI secretion system IcmF C-terminal
Gamma-glutamylcyclotransferase AIG2-like
Alanyl-transfer RNA synthetases family profile
Plays an important role in substrate specificity
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Release factor glutamine methyltransferase N-terminal
Adaptive response protein AidB N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Proton acceptor; for glutaminase activity
Flavocytochrome c sulphide dehydrogenase flavin-binding
Prokaryotic-type class I peptide chain release factors
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Reversibly protonated during proton transport
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Membrane insertase YidC/Oxa/ALB C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
N-end rule aminoacyl transferase C-terminal
Saccharopine dehydrogenase-like C-terminal
Beta-lactamase hydrolase-like protein phosphatase-like
Chromosomal replication initiator protein DnaA
Integral membrane protein YccS N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Glycine zipper 2TM domain-containing protein
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Type IV pilus biogenesis and competence protein PilQ
Quercetin 2,3-dioxygenase C-terminal cupin
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Ribulose bisphosphate carboxylase small subunit
O-(3'-phospho-DNA)-tyrosine intermediate
Ribosomal RNA adenine methylase transferase N-terminal
Methylamine/Aralkylamine dehydrogenase light chain C-terminal
Tryptophylquinone 6'-substrate hemiaminal intermediate
Terminase large subunit-like endonuclease
YbaK/aminoacyl-tRNA synthetase-associated
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Involved in tetramerization or stability of the tetramer
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Slight decrease in catalytic efficiency, but still acts as a desulfinase. Does not gain acyl-CoA dehydrogenase activity.
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Required for zinc-mediated homotetramerization and catalytic activity
Biopterin-dependent aromatic amino acid hydroxylase family profile
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Outer membrane protein assembly factor BamA
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Malonate/sodium symporter MadM subunit N-terminal
Glycosyl transferase family 3 N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Pyruvate dehydrogenase E1 component middle
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Large ribosomal subunit protein uL15/eL18
Aminoacyl-tRNA synthetase class I anticodon-binding
Glyoxalase/fosfomycin resistance/dioxygenase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Essential for prephenate dehydratase activity
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation