Major facilitator superfamily (MFS) profile
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Outer membrane protein beta-barrel domain-containing protein
Peptidase M1 membrane alanine aminopeptidase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
TonB-dependent receptor plug domain-containing protein
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Centromere protein J C-terminal domain-containing protein
CobB/CobQ-like glutamine amidotransferase
Transglutaminase-like domain-containing protein
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Electron transfer flavoprotein alpha/beta-subunit N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Tryptophan synthase beta chain-like PALP
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
3-keto-disaccharide hydrolase domain-containing protein
Moves into active site upon enzyme activation, plays a role in electron transfer
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
NIF system FeS cluster assembly NifU N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Glycosyl-hydrolase 97 C-terminal oligomerisation
Phosphatidate phosphatase APP1 catalytic
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Heme-copper oxidase subunit III family profile
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
Plays an important role in substrate specificity
SusD/RagB family nutrient-binding outer membrane lipoprotein
Type I restriction modification DNA specificity
RND efflux pump membrane fusion protein barrel-sandwich
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Pseudouridine synthase I TruA alpha/beta
Secretion system C-terminal sorting domain-containing protein
TonB-dependent receptor-like beta-barrel
Glycosyltransferase subfamily 4-like N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Phosphatidic acid phosphatase type 2/haloperoxidase
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
FAD-dependent oxidoreductase 2 FAD binding
Polysaccharide biosynthesis protein CapD-like
Urease accessory protein UreH-like transmembrane
Large ribosomal subunit protein bL9 C-terminal
Alpha-galactosidase NEW3 domain-containing protein
Type IX secretion system protein PorV domain-containing protein
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Resolvase/invertase-type recombinase catalytic
Large ribosomal subunit protein uL2 C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Phage terminase large subunit N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Polymerase/histidinol phosphatase N-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Translation elongation factor P/YeiP central
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Prokaryotic-type class I peptide chain release factors
Formamidopyrimidine-DNA glycosylase catalytic
Nitrite/Sulfite reductase ferredoxin-like
Membrane insertase YidC/Oxa/ALB C-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Peptidase M14 carboxypeptidase A domain-containing protein
Signal transduction histidine kinase internal region
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Saccharopine dehydrogenase-like C-terminal
Gliding motility associated protein GldN
Integral membrane protein YccS N-terminal
Penicillin-binding protein transpeptidase
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Proton acceptor; for glutaminase activity
Cation-transporting P-type ATPase C-terminal
Cation-transporting P-type ATPase N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Mannose-6-phosphate isomerase type II C-terminal
Lipocalin-like domain-containing protein
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
PLD phosphodiesterase domain-containing protein
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Carbamoyl-phosphate synthase small subunit N-terminal
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
Beta-xylosidase C-terminal Concanavalin A-like
Type IX secretion system membrane protein PorP/SprF
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
TonB C-terminal domain-containing protein
Molybdopterin cofactor biosynthesis C (MoaC)
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Glucosamine/galactosamine-6-phosphate isomerase
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Shikimate dehydrogenase substrate binding N-terminal
Gliding motility protein SprA N-terminal domain-containing protein
Polysaccharide biosynthesis protein C-terminal
AB hydrolase-1 domain-containing protein
Quercetin 2,3-dioxygenase C-terminal cupin
ATP-grasp fold succinyl-CoA synthetase-type
Twin-arginine translocation pathway signal
Aspartate/homoserine dehydrogenase NAD-binding
Glycine zipper 2TM domain-containing protein
Alpha-D-phosphohexomutase alpha/beta/alpha
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Could be important to modulate the pK values of the two catalytic cysteine residues
Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein
S-adenosyl-L-homocysteine hydrolase NAD binding
Biopterin-dependent aromatic amino acid hydroxylase family profile
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Membrane fusion protein biotin-lipoyl like
DNA mismatch repair proteins mutS family
Phosphate starvation-inducible protein PsiF
ABC-type uncharacterised transport system
tRNA pseudouridylate synthase B C-terminal
Curlin associated repeat-containing protein
RND efflux pump membrane fusion protein barrel-sandwich domain-containing protein
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Bacterial surface antigen (D15) domain-containing protein
Tetrahydrodipicolinate-N-succinyltransferase chain A
Chromosomal replication initiator DnaA C-terminal
Polysaccharide chain length determinant N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Carboxypeptidase regulatory-like domain-containing protein
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
5'-Nucleotidase C-terminal domain-containing protein
peptide-methionine (R)-S-oxide reductase
Thiopeptide-type bacteriocin biosynthesis
Pyrroline-5-carboxylate reductase catalytic N-terminal
Schiff-base intermediate with acetaldehyde
Positions MEP for the nucleophilic attack
Small ribosomal subunit protein uS4 N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
RNA binding; important for wobble base 34 recognition
Curli production assembly/transport component CsgF
RNA polymerase sigma factor 70 region 4 type 2
Phosphoadenosine phosphosulphate reductase
Beta-lactamase-related domain-containing protein
Beta-hexosaminidase eukaryotic type N-terminal
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Long-chain fatty acid transporter permease
DNA topoisomerase I catalytic core eukaryotic-type
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
40-residue YVTN family beta-propeller repeat-containing protein
Secretin/TonB short N-terminal domain-containing protein
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Outer membrane lipoprotein carrier protein LolA
Electron transfer via tryptophanyl radical
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Trigger factor ribosome-binding bacterial
Gliding motility-associated lipoprotein GldH
DNA replication/recombination mediator RecO N-terminal
Peptidase M10 metallopeptidase domain-containing protein
Carboxypeptidase-like regulatory domain-containing protein
NIF system FeS cluster assembly NifU C-terminal
Glycine cleavage T-protein C-terminal barrel
Probable endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Sulfatase-modifying factor enzyme domain-containing protein
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Glycosyl transferase family 3 N-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Ribose-phosphate pyrophosphokinase N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Haem-binding uptake Tiki superfamily ChaN domain-containing protein
Activator of Hsp90 ATPase homologue 1-like C-terminal
Pyridoxamine 5'-phosphate oxidase putative
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Signal transduction histidine kinase internal region domain-containing protein
Peptidase M12A domain-containing protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Bacterial bifunctional deaminase-reductase C-terminal
SusE outer membrane protein domain-containing protein
Peptidase M43 pregnancy-associated plasma-A
Peptidase M43 pregnancy-associated plasma-A domain-containing protein
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Peptidase M1 membrane alanine aminopeptidase domain-containing protein
Schiff-base intermediate with substrate; via pyruvic acid
Glycosyl hydrolase family 13 catalytic domain-containing protein
General stress protein FMN-binding split barrel
Important for beta-aspartyl-AMP intermediate formation
Organic solvent tolerance-like N-terminal
Organic solvent tolerance-like N-terminal domain-containing protein
Peptidase S8/S53 domain-containing protein
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
UDP N-acetylglucosamine O-acyltransferase C-terminal
Thymidylate synthase/dCMP hydroxymethylase
Putative auto-transporter adhesin head GIN
Putative auto-transporter adhesin head GIN domain-containing protein
Putative exodeoxyribonuclease 8 PDDEXK-like
Glycosyl hydrolase family 30 beta sandwich
YMGG-like Gly-zipper domain-containing protein
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Antitoxin Xre/MbcA/ParS-like toxin-binding
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
VPDSG-CTERM protein sorting domain-containing protein
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
DNA primase/polymerase bifunctional N-terminal
Anthranilate synthase component I N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
ATP synthase F1 complex delta/epsilon subunit N-terminal
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Right handed beta helix domain-containing protein
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Increases nucleophilicity of active site Cys
Large ribosomal subunit protein uL15/eL18
Heavy metal binding domain-containing protein
S-adenosylmethionine-dependent methyltransferase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Ricin B lectin domain-containing protein
PhoD-like phosphatase metallophosphatase
PhoD-like phosphatase metallophosphatase domain-containing protein
Type 1 periplasmic binding fold superfamily protein
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Helix-hairpin-helix domain-containing protein
Phosphoribosylformylglycinamidine synthase linker
Gly-cisPro motif, important for rejection of L-amino acids
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Histidine-specific methyltransferase SAM-dependent
Arabinogalactan endo-beta-1,4-galactanase
Toxin-antitoxin system YwqK family antitoxin
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Peptide methionine sulphoxide reductase MsrA
Metallo-beta-lactamase domain-containing protein