Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Major facilitator superfamily (MFS) profile
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Twin-arginine translocation signal domain-containing protein
RND efflux pump membrane fusion protein barrel-sandwich
S-adenosylmethionine-dependent methyltransferase
Essential for prephenate dehydratase activity
Peptidase S9 prolyl oligopeptidase catalytic
Tryptophan synthase beta chain-like PALP
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
Resolvase/invertase-type recombinase catalytic
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Alpha-D-phosphohexomutase alpha/beta/alpha
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Rap1a immunity protein domain-containing protein
Tetrahydrodipicolinate-N-succinyltransferase chain A
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Prokaryotic-type class I peptide chain release factors
Superoxide dismutase copper/zinc binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Transcription elongation factor GreA/GreB C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Transcription elongation factor GreA/GreB N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Penicillin-binding protein transpeptidase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Glucose-methanol-choline oxidoreductase N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
TonB-dependent receptor-like beta-barrel
Glycosyltransferase subfamily 4-like N-terminal
Polysaccharide chain length determinant N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Pyruvate/ketoisovalerate oxidoreductase catalytic
Thiamine pyrophosphate enzyme TPP-binding
Quinohemoprotein amine dehydrogenase gamma subunit structural
TtsA-like Glycoside hydrolase family 108
Cytochrome c oxidase subunit IV bacterial aa3 type
RNA polymerase sigma factor 70 region 4 type 2
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Small ribosomal subunit protein uS4 N-terminal
Glycine cleavage T-protein C-terminal barrel
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Membrane fusion protein biotin-lipoyl like
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
N-sulphoglucosamine sulphohydrolase C-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Carbamoyl-phosphate synthase small subunit N-terminal
Important for beta-aspartyl-AMP intermediate formation
General stress protein FMN-binding split barrel
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Heme-copper oxidase subunit III family profile
Signal transduction histidine kinase subgroup 2 dimerisation and phosphoacceptor
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Flagella basal body P-ring formation protein FlgA C-terminal
Exonuclease VII large subunit C-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Poly-beta-hydroxybutyrate polymerase N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Aminoacyl-transfer RNA synthetases class-II family profile
Alanyl-transfer RNA synthetases family profile
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Plays an important role in substrate specificity
Flagellar motor switch protein FliN-like C-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
SUF system FeS cluster assembly SufBD N-terminal
Cobaltochelatase subunit CobS N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Glucan biosynthesis periplasmic MdoG C-terminal
Glucan biosynthesis periplasmic MdoG C-terminal domain-containing protein
PhoD-like phosphatase metallophosphatase
tRNA pseudouridylate synthase B C-terminal
Glycosyl transferase family 3 N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Pyrroline-5-carboxylate reductase dimerisation
DNA replication/recombination mediator RecO N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Proton acceptor; for glutaminase activity
Glycosyl-hydrolase 97 C-terminal oligomerisation
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Probable periplasmic serine endoprotease DegP-like
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Anthranilate synthase component I N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Beta-lactamase hydrolase-like protein phosphatase-like
Bacterial type II secretion system protein E
CagE TrbE VirB component of type IV transporter system central
Ribosomal RNA adenine methylase transferase N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Alpha-glycerophosphate oxidase C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Large ribosomal subunit protein uL15/eL18
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Interaction with polymerase core subunit RpoC
S-adenosyl-L-homocysteine hydrolase NAD binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Organic solvent tolerance-like N-terminal
Outer membrane protein assembly factor BamD
O-(3'-phospho-DNA)-tyrosine intermediate
FAD-dependent oxidoreductase 2 FAD binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Activator of Hsp90 ATPase homologue 1-like C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
Curli production assembly/transport component CsgG
Peptidase M20 dimerisation domain-containing protein
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
RNA 2-O ribose methyltransferase substrate binding
Type IV secretion system coupling protein TraD DNA-binding
Could play a key role in the communication between the regulatory and the substrate sites
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Cytochrome b561 bacterial/Ni-hydrogenase
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Transposase IS116/IS110/IS902 C-terminal
PQQ-dependent catabolism-associated beta-propeller protein
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Helix-hairpin-helix DNA-binding motif class 1
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase-like C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Disulphide bond isomerase DsbC/G N-terminal
DNA-directed DNA polymerase family A palm
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Peptide methionine sulphoxide reductase MsrA
Molybdopterin cofactor biosynthesis C (MoaC)
Endoribonuclease L-PSP/chorismate mutase-like
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Alginate export domain-containing protein
Putative glycogen debranching enzyme N-terminal
Vanillate O-demethylase oxygenase-like C-terminal catalytic
Nitrite/Sulfite reductase ferredoxin-like
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Shikimate dehydrogenase substrate binding N-terminal
ABC-type transport auxiliary lipoprotein component
O-(5'-phospho-DNA)-tyrosine intermediate
Large ribosomal subunit protein uL6 alpha-beta
Large ribosomal subunit protein uL2 C-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Cysteine sulfenic acid (-SOH) intermediate
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
NAD(P) transhydrogenase alpha subunit C-terminal
Translation elongation factor P/YeiP central
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Pseudouridine synthase I TruA alpha/beta
Signal recognition particle SRP54 helical bundle
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Tetratricopeptide repeat-like domain-containing protein
Type II secretion system protein GspC N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Chromosomal replication initiator DnaA C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Histidine phosphotransferase ChpT C-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Outer membrane protein beta-barrel domain-containing protein
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Quercetin 2,3-dioxygenase C-terminal cupin
Methylamine/Aralkylamine dehydrogenase light chain C-terminal
Tryptophylquinone 6'-substrate hemiaminal intermediate
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Bacterial DNA polymerase III alpha subunit NTPase
DNA polymerase helix-hairpin-helix motif
Survival protein SurE-like phosphatase/nucleotidase
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
CDP-alcohol phosphatidyltransferase C-terminal
YbaK/aminoacyl-tRNA synthetase-associated
CobB/CobQ-like glutamine amidotransferase
Reversibly protonated during proton transport
Biopterin-dependent aromatic amino acid hydroxylase family profile
Conjugal transfer pilus assembly protein TraA
Gamma-glutamylcyclotransferase AIG2-like
Solute-binding protein family 3/N-terminal
RNA binding; important for wobble base 34 recognition
N-end rule aminoacyl transferase C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Polymerase/histidinol phosphatase N-terminal
Release factor glutamine methyltransferase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Putative Flp pilus-assembly TadG-like N-terminal
Saccharopine dehydrogenase-like C-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Heat-inducible transcription repressor HrcA C-terminal
Caspase family p20 domain-containing protein
DNA mismatch repair proteins mutS family
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
NADH:ubiquinone oxidoreductase 30kDa subunit
Polysaccharide biosynthesis protein C-terminal
PHA accumulation regulator DNA-binding N-terminal
Extracellular exo-alpha-(1->5)-L-arabinofuranosidase
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
Phosphoribosylformylglycinamidine synthase linker
ABC-type transport auxiliary lipoprotein component domain-containing protein
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Quinohemoprotein amine dehydrogenase alpha subunit
Quinohemoprotein amine dehydrogenase alpha subunit haem binding
Signal transduction histidine kinase dimerisation/phosphoacceptor
Type VII secretion system protein EssD-like
Methionyl-tRNA synthetase anticodon-binding
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Histidine-specific methyltransferase SAM-dependent
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Gram-positive cocci surface proteins LPxTG domain-containing protein