Phosphotransferase system enzyme I N-terminal
Major facilitator superfamily (MFS) profile
Saccharopine dehydrogenase-like C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Glycosyl transferase family 3 N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
RNA polymerase sigma factor 70 region 4 type 2
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glycosyltransferase subfamily 4-like N-terminal
6-phosphogluconate dehydrogenase NADP-binding
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Thiopeptide-type bacteriocin biosynthesis
Glycoside hydrolase family 42 N-terminal
Tat pathway signal sequence domain protein
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Phosphoadenosine phosphosulphate reductase
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Cytochrome C biogenesis protein transmembrane
O-(5'-phospho-DNA)-tyrosine intermediate
Alpha-D-phosphohexomutase alpha/beta/alpha
S-adenosyl-L-homocysteine hydrolase NAD binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Histidine-specific methyltransferase SAM-dependent
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Polymerase/histidinol phosphatase N-terminal
Plays an important role in substrate specificity
Schiff-base intermediate with substrate; via topaquinone
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Pyrroline-5-carboxylate reductase dimerisation
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Removed in mature form; by autocatalysis
YbaK/aminoacyl-tRNA synthetase-associated
Polysaccharide lyase 8 N-terminal alpha-helical
Polysaccharide lyase family 8 C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
PsrA tetracyclin repressor-like C-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Phosphatidic acid phosphatase type 2/haloperoxidase
Tryptophan synthase beta chain-like PALP
Subtilisin inhibitor domain-containing protein
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
DnaJ homologue subfamily C member 28 conserved
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Acetylserotonin O-methyltransferase dimerisation
Alpha-L-arabinofuranosidase B arabinose-binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Putative glycogen debranching enzyme N-terminal
Methionyl-tRNA synthetase anticodon-binding
Cation-transporting P-type ATPase N-terminal
Glycoside hydrolase family 5 domain-containing protein
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Superoxide dismutase copper/zinc binding
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Pyridoxamine 5'-phosphate oxidase putative
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
4'-phosphopantetheinyl transferase N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
DNA primase/polymerase bifunctional N-terminal
Shikimate dehydrogenase substrate binding N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
Helix-hairpin-helix DNA-binding motif class 1
Peptidase S9 prolyl oligopeptidase catalytic
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein
Abnormal spindle-like microcephaly-associated protein ASH
Aminoacyl-transfer RNA synthetases class-II family profile
Putative oxidoreductase/dehydrogenase Rossmann-like
Adaptive response protein AidB N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Gram-positive cocci surface proteins LPxTG
Gram-positive cocci surface proteins LPxTG domain-containing protein
Glycosyl transferase family 28 C-terminal
Anthranilate synthase component I N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Peptidase M1 membrane alanine aminopeptidase
ATP synthase F1 complex delta/epsilon subunit N-terminal
NIF system FeS cluster assembly NifU N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Endonuclease/exonuclease/phosphatase domain-containing protein
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Prokaryotic-type class I peptide chain release factors
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
8-demethyl-8-aminoriboflavin-5'-phosphate synthase
Important to position the amino-group donor glutamate
Loss of synthase activity due to the absence of substrate binding.
Loss of synthase activity due to the reduced ability to catalyze the introduction of an amino group and predominantly to synthesize 8-demethyl-8-carboxyriboflavin-5'-phosphate (HO2C-RP) intermediate.
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Alpha-glycerophosphate oxidase C-terminal
Positions MEP for the nucleophilic attack
Bacterial bifunctional deaminase-reductase C-terminal
Transposase IS116/IS110/IS902 C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Activator of Hsp90 ATPase homologue 1-like C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Penicillin-binding protein transpeptidase
Could play a key role in the communication between the regulatory and the substrate sites
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
Cytochrome b/b6 N-terminal region profile
N-acetylneuraminic acid synthase N-terminal
NIF system FeS cluster assembly NifU C-terminal
Transition state stabilizer; via amide nitrogen
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Xylose isomerase-like TIM barrel domain-containing protein
Important for substrate specificity; cannot use PPi as phosphoryl donor
Solute-binding protein family 3/N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Heme-copper oxidase subunit III family profile
Nitrite/Sulfite reductase ferredoxin-like
Lactate utilization protein B C-terminal
Glycosyl hydrolase-like 10 domain-containing protein
Ricin B lectin domain-containing protein
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Ribose-phosphate pyrophosphokinase N-terminal
vWA-MoxR associated protein middle region 0
Large ribosomal subunit protein uL2 C-terminal
Glycine cleavage T-protein C-terminal barrel
Mandelate racemase/muconate lactonizing enzyme C-terminal
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Peptidoglycan binding-like domain-containing protein
PhoD-like phosphatase metallophosphatase
Sporulation transcription regulator WhiA N-terminal
Pseudouridine synthase I TruA alpha/beta
Pyruvate dehydrogenase E1 component middle
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Acyltransferase MbtK/IucB-like conserved
Glycerophosphoryl diester phosphodiesterase membrane
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Tetracyclin repressor-like C-terminal group 31
CobB/CobQ-like glutamine amidotransferase
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Endoribonuclease L-PSP/chorismate mutase-like
UDP-glucose/GDP-mannose dehydrogenase C-terminal
AB hydrolase-1 domain-containing protein
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
ABC-type glycine betaine transport system substrate-binding
Schiff-base intermediate with D-ribose 5-phosphate
Myo-inositol-1-phosphate synthase GAPDH-like
Chromosomal replication initiator DnaA C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Gp5/Type VI secretion system Vgr protein OB-fold
Alanyl-transfer RNA synthetases family profile
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-109)
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Glycosyltransferase family 28 N-terminal
Proton acceptor; for glutaminase activity
Reversibly protonated during proton transport
Peptidoglycan recognition protein family
Cell envelope-related transcriptional attenuator
Pyruvate phosphate dikinase AMP/ATP-binding
Putative regulatory protein FmdB Zinc ribbon
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH-rubredoxin oxidoreductase C-terminal
Transglycosylase SLT domain-containing protein
Small ribosomal subunit protein uS4 N-terminal
LPXTG cell wall anchor domain-containing protein
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Peptidase M43 pregnancy-associated plasma-A
Bacterial type II secretion system protein E
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Carbamoyl-phosphate synthase small subunit N-terminal
Beta-hexosaminidase bacterial type N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Release factor glutamine methyltransferase N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Peptide methionine sulphoxide reductase MsrA
non-reducing end alpha-L-arabinofuranosidase
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
6-phosphogluconate dehydrogenase C-terminal
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Microcin J25-processing protein McjB C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
RNA 2-O ribose methyltransferase substrate binding
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
SUF system FeS cluster assembly SufBD N-terminal
Probable subtilase-type protease inhibitor
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Essential for prephenate dehydratase activity
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
BetI-type transcriptional repressor C-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Glycoside hydrolase family 31 N-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Glycosyl-hydrolase 97 C-terminal oligomerisation
Glycoside-hydrolase family GH114 TIM-barrel
Conserved hypothetical protein CHP02679 N terminus
Phosphocysteine intermediate; for EIIB activity
2,4-diaminopentanoate dehydrogenase C-terminal
DNA-directed DNA polymerase family A palm
Molybdopterin cofactor biosynthesis C (MoaC)
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Leucine-binding protein domain-containing protein
Schiff-base intermediate with substrate; via pyruvic acid
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Cell wall-active antibiotics response LiaF-like C-terminal
Probable transposase IS891/IS1136/IS1341
Threonine/serine exporter-like N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Phosphomannose isomerase type I catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Phosphoribosylformylglycinamidine synthase linker
Interaction with polymerase core subunit RpoC
DNA replication/recombination mediator RecO N-terminal
Ionotropic glutamate receptor C-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
MmyB-like transcription regulator ligand binding
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Putative Flp pilus-assembly TadG-like N-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
Erythromycin biosynthesis protein CIII-like central
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Glutathionylspermidine synthase pre-ATP-grasp-like
SsuA/THI5-like domain-containing protein
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Styrene monooxygenase StyA putative substrate binding
Translation elongation factor P/YeiP central
Transcription regulator AsnC/Lrp ligand binding
Periplasmic copper-binding protein NosD beta helix
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
L-aspartate N-monooxygenase (nitrosuccinate-forming)
Damage-control phosphatase ARMT1-like metal-binding
Nicotinate phosphoribosyltransferase N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Prepilin type IV endopeptidase peptidase
Large ribosomal subunit protein uL15/eL18
Ribosomal RNA adenine methylase transferase N-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Metallo-beta-lactamase domain-containing protein
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
ABC transporter substrate-binding protein PnrA-like
Involved in allosteric activation by GTP
Involved in ionization of N3 of dUMP, leading to its activation
Arabinogalactan endo-beta-1,4-galactanase
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Cysteine sulfenic acid (-SOH) intermediate
vWA-MoxR associated protein middle region 7
Heat-inducible transcription repressor HrcA C-terminal
N,N-dimethylformamidase beta subunit-like C-terminal