Aminoacyl-transfer RNA synthetases class-II family profile
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Phosphate ABC transporter substrate-binding protein
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Thymidylate synthase/dCMP hydroxymethylase
Translation elongation factor P/YeiP central
Prokaryotic-type class I peptide chain release factors
Periplasmic binding protein/LacI sugar binding
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Flagellar assembly protein FliH/Type III secretion system HrpE
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Quercetin 2,3-dioxygenase C-terminal cupin
Bacterial bifunctional deaminase-reductase C-terminal
Electron transfer via tryptophanyl radical
Major facilitator superfamily (MFS) profile
FAD-dependent oxidoreductase 2 FAD binding
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Resolvase/invertase-type recombinase catalytic
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Bacterial type II secretion system protein E
25S rRNA (uridine-N(3))-methyltransferase BMT5-like
Cytochrome b561 bacterial/Ni-hydrogenase
6-phosphogluconate dehydrogenase C-terminal
Threonine/serine exporter-like N-terminal
Curli production assembly/transport component CsgG
Glyoxalase/fosfomycin resistance/dioxygenase
Endolytic peptidoglycan transglycosylase RlpA
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Lytic transglycosylase superhelical linker
Could play a key role in the communication between the regulatory and the substrate sites
O-(5'-phospho-DNA)-tyrosine intermediate
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Phosphatidic acid phosphatase type 2/haloperoxidase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Mechanosensitive ion channel inner membrane
Pseudouridine synthase I TruA alpha/beta
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Phosphocysteine intermediate; for EIIB activity
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
RND efflux pump membrane fusion protein barrel-sandwich
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Tryptophan synthase beta chain-like PALP
O-(3'-phospho-DNA)-tyrosine intermediate
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Large ribosomal subunit protein bL25 L25
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Erythronate-4-phosphate dehydrogenase dimerisation
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Cytochrome C biogenesis protein transmembrane
Thiol:disulfide interchange protein DsbD N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Schiff-base intermediate with substrate; via pyruvic acid
Polysaccharide chain length determinant N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase subfamily 4-like N-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Ribosomal RNA adenine methylase transferase N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
C-type lysozyme inhibitor domain-containing protein
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Acyl-ester intermediate; for transpeptidase activity
Penicillin-binding protein transpeptidase
Proton donor; for transglycosylase activity
Chromosomal replication initiator DnaA C-terminal
Solute-binding protein family 3/N-terminal
Sodium/calcium exchanger membrane region
Interaction with polymerase core subunit RpoC
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
For 3-hydroxyacyl-CoA dehydrogenase activity
Acyltransferase MbtK/IucB-like conserved
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
TonB-dependent receptor-like beta-barrel
Peptide methionine sulphoxide reductase MsrA
Cysteine sulfenic acid (-SOH) intermediate
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Large ribosomal subunit protein uL6 alpha-beta
Plays an important role in substrate specificity
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Curli production assembly/transport component CsgE
Homogentisate 1,2-dioxygenase N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Periplasmic nitrate reductase, electron transfer subunit
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Transposon Tn7 transposition protein TnsD C-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Appears to be important in orienting the phosphate for catalysis
Important for substrate binding and specificity
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Polysaccharide biosynthesis protein CapD-like
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
N6 adenine-specific DNA methyltransferase N-terminal
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
Membrane fusion protein biotin-lipoyl like
Translocation and assembly module subunit TamA
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Plays an important role in discriminating NADH against NADPH
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Anthranilate synthase component I N-terminal
Ionotropic glutamate receptor C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
ABC-type glycine betaine transport system substrate-binding
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
N-end rule aminoacyl transferase C-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Peptidase S9 prolyl oligopeptidase catalytic
Type II secretion system protein GspC N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
UDP N-acetylglucosamine O-acyltransferase C-terminal
Alpha-glycerophosphate oxidase C-terminal
Haem-binding uptake Tiki superfamily ChaN
DNA polymerase III delta subunit C-terminal
Choloylglycine hydrolase/NAAA C-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Small-conductance mechanosensitive channel
Tellurite resistance methyltransferase TehB-like
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Exonuclease VII large subunit C-terminal
Gamma-butyrobetaine hydroxylase-like N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
7 transmembrane helices usually fused to an inactive transglutaminase
Inactive transglutaminase fused to 7 transmembrane helices
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Transcriptional regulator SgrR N-terminal HTH
Fatty acid synthase subunit PfaD N-terminal
Menaquinone biosynthesis protein MenD middle
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Large ribosomal subunit protein uL2 C-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Required for dimer formation and molybdate binding
Serine/threonine specific protein phosphatases
Flagellar assembly protein T N-terminal domain-containing protein
Small ribosomal subunit protein uS4 N-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
AMP-activated protein kinase glycogen-binding
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
NIF system FeS cluster assembly NifU C-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
RNA methyltransferase SpoU/TrmH type C-terminal
Sugar fermentation stimulation protein C-terminal
DNA replication/recombination mediator RecO N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Probable lipopolysaccharide assembly protein A
Water stress and hypersensitive response
YbaK/aminoacyl-tRNA synthetase-associated
Glucosamine/galactosamine-6-phosphate isomerase
Biopterin-dependent aromatic amino acid hydroxylase family profile
Prepilin type IV endopeptidase peptidase
NIF system FeS cluster assembly NifU N-terminal
Moybdenum cofactor oxidoreductase dimerisation
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Polymerase/histidinol phosphatase N-terminal
Schiff-base intermediate with acetaldehyde
Important for beta-aspartyl-AMP intermediate formation
Sodium symporter small subunit predicted
Transglycosylase SLT domain-containing protein
Outer membrane protein assembly factor BamD
Acyl-CoA dehydrogenase C-terminal bacterial-type
ATP synthase F1 complex delta/epsilon subunit N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Bacterial virulence factor lipase N-terminal
Bacterial virulence factor lipase N-terminal domain-containing protein
Fungal lipase-like domain-containing protein
Aspartate/homoserine dehydrogenase NAD-binding
Methylguanine DNA methyltransferase ribonuclease-like
Alanyl-transfer RNA synthetases family profile
PhoD-like phosphatase metallophosphatase
Type I restriction modification DNA specificity
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Integral membrane protein YccS N-terminal
Photosynthesis system II assembly factor Ycf48/Hcf136-like
Photosynthesis system II assembly factor Ycf48/Hcf136-like domain-containing protein
Outer-membrane lipoprotein Wza C-terminal
Type II secretion system protein GspG C-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Membrane-bound lytic murein transglycosylase F
Phosphotransferase system enzyme I N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Glucose-methanol-choline oxidoreductase C-terminal
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Saccharopine dehydrogenase-like C-terminal
NADH:ubiquinone oxidoreductase intermediate-associated protein 30
Cytochrome c-type biogenesis protein CcmF C-terminal
Virulence factor membrane-bound polymerase C-terminal
RNA binding; important for wobble base 34 recognition
Flagellar motor switch protein FliN-like C-terminal
RlpA-like protein double-psi beta-barrel
Important for interaction with partner proteins
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Terminase large subunit gp17-like C-terminal
Cytochrome oxidase subunit II copper A binding
Could be important to modulate the pK values of the two catalytic cysteine residues
Glycosyltransferase family 28 N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Heme-copper oxidase subunit III family profile
Glycine cleavage T-protein C-terminal barrel
DNA mismatch repair proteins mutS family
Pyruvate dehydrogenase E1 component middle
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Magnesium transporter MgtE intracellular
Interacts with tRNA; defines subfamily-specific binding signature
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Signal transduction histidine kinase 5TM receptor LytS transmembrane region
Signal transduction histidine kinase internal region
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Outer membrane protein assembly factor BamA
Disulphide bond isomerase DsbC/G N-terminal
Shikimate dehydrogenase substrate binding N-terminal
6-hydroxymethylpterin diphosphokinase MptE-like
Chitobiase/beta-hexosaminidases N-terminal
Positions MEP for the nucleophilic attack
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Helix-hairpin-helix DNA-binding motif class 1
CobB/CobQ-like glutamine amidotransferase
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Ion-translocating oxidoreductase complex subunit G
Carbamoyl-phosphate synthase small subunit N-terminal
Major facilitator superfamily associated
Large ribosomal subunit protein uL15/eL18
Flagella basal body P-ring formation protein FlgA
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Flagellar Assembly Protein A N-terminal region
Alpha-D-phosphohexomutase alpha/beta/alpha
DNA-directed DNA polymerase family A palm
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Reversibly protonated during proton transport
Predicted DNA-binding protein ribbon-helix-helix
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Membrane insertase YidC/Oxa/ALB C-terminal
Glycosyl transferase family 3 N-terminal
Involved in tetramerization or stability of the tetramer
nitrite reductase (cytochrome; ammonia-forming)
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
S-adenosylmethionine-dependent methyltransferase
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Urease accessory protein UreH-like transmembrane
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Type II secretion system protein GspI C-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Release factor glutamine methyltransferase N-terminal
RNA 2-O ribose methyltransferase substrate binding
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Outer-membrane lipoprotein carrier protein
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Flagellar hook-length control protein-like C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Cytochrome c-552/DMSO reductase-like haem-binding
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
DNA polymerase III subunit delta C-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom