SUF system FeS cluster assembly SufBD N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Major facilitator superfamily (MFS) profile
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Acyl-CoA dehydrogenase/oxidase C-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Acyl-CoA dehydrogenase/oxidase N-terminal
Solute-binding protein family 5 domain-containing protein
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Peptidase S9 prolyl oligopeptidase catalytic
Involved in ionization of N3 of dUMP, leading to its activation
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Aminoacyl-transfer RNA synthetases class-II family profile
Pyruvate dehydrogenase E1 component middle
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
DNA-directed DNA polymerase family A palm
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Important for substrate specificity; cannot use PPi as phosphoryl donor
Phosphatidic acid phosphatase type 2/haloperoxidase
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Cytochrome b/b6 N-terminal region profile
Cation-transporting P-type ATPase N-terminal
Schiff-base intermediate with D-ribose 5-phosphate
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Prokaryotic-type class I peptide chain release factors
Interaction with polymerase core subunit RpoC
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
ATP synthase F1 complex delta/epsilon subunit N-terminal
Phosphocysteine intermediate; for EIIB activity
DNA primase/polymerase bifunctional N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Putative host cell surface-exposed lipoprotein Ltp-like HTH region
Resuscitation-promoting factor Rpf1 C-terminal
Resuscitation-promoting factor core lysozyme-like
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
DNA replication/recombination mediator RecO N-terminal
Schiff-base intermediate with acetaldehyde
Glucose-methanol-choline oxidoreductase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Cysteine sulfenic acid (-SOH) intermediate
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Aconitase A/isopropylmalate dehydratase small subunit swivel
Large ribosomal subunit protein uL2 C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Membrane insertase YidC/Oxa/ALB C-terminal
Heme-copper oxidase subunit III family profile
Translation elongation factor P/YeiP central
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Alpha-D-phosphohexomutase alpha/beta/alpha
Heat-inducible transcription repressor HrcA C-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Phosphoribosylformylglycinamidine synthase linker
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Inosine/uridine-preferring nucleoside hydrolase
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Chromosomal replication initiator DnaA C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Resolvase/invertase-type recombinase catalytic
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Thioredoxin-like fold domain-containing protein
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Protein O-mannosyl-transferase C-terminal four TM
Penicillin-binding protein transpeptidase
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Alanyl-transfer RNA synthetases family profile
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Alpha-glycerophosphate oxidase C-terminal
Cytochrome C biogenesis protein transmembrane
Large ribosomal subunit protein uL15/eL18
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Important for beta-aspartyl-AMP intermediate formation
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Sigma 54 modulation/S30EA ribosomal protein C-terminal
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Type III restriction enzyme C-terminal endonuclease
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Could play a key role in the communication between the regulatory and the substrate sites
Periplasmic binding protein domain-containing protein
NADH:flavin oxidoreductase/NADH oxidase N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Large ribosomal subunit protein uL30-like ferredoxin-like fold
SsuA/THI5-like domain-containing protein
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Cell envelope-related transcriptional attenuator
Putative oxidoreductase/dehydrogenase Rossmann-like
RNA binding; important for wobble base 34 recognition
Methionyl-tRNA synthetase anticodon-binding
Ribosomal RNA small subunit methyltransferase E methyltransferase
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Polymerase/histidinol phosphatase N-terminal
RNA 2-O ribose methyltransferase substrate binding
Peptide methionine sulphoxide reductase MsrA
Large ribosomal subunit protein uL6 alpha-beta
Tryptophan synthase beta chain-like PALP
S-adenosyl-L-homocysteine hydrolase NAD binding
Release factor glutamine methyltransferase N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Ribosomal RNA adenine methylase transferase N-terminal
NIF system FeS cluster assembly NifU N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
CobB/CobQ-like glutamine amidotransferase
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Na+/H+ antiporter MnhB subunit-related protein
Type I restriction enzyme R protein N-terminal
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase
Pyruvate phosphate dikinase AMP/ATP-binding
L,D-transpeptidase catalytic domain-containing protein
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
ATP-dependent DNA helicase RecG C-terminal
Acyltransferase MbtK/IucB-like conserved
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Glycine cleavage T-protein C-terminal barrel
Phosphomannose isomerase type I catalytic
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Bacterial type II secretion system protein E
HTH-type transcriptional repressor NicS C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Reversibly protonated during proton transport
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Sodium/calcium exchanger membrane region
Transposase IS204/IS1001/IS1096/IS1165 DDE
Glucosamine/galactosamine-6-phosphate isomerase
Pseudouridine synthase I TruA alpha/beta
Solute-binding protein family 3/N-terminal
Solute-binding protein family 3/N-terminal domain-containing protein
PhoD-like phosphatase metallophosphatase
Phosphodiesterase/alkaline phosphatase D
Arabinofuranosyltransferase AftA C-terminal
Arabinofuranosyltransferase AftA N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Small ribosomal subunit protein uS4 N-terminal
Fe/B12 periplasmic-binding domain-containing protein
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
Thymidylate synthase/dCMP hydroxymethylase
4'-phosphopantetheinyl transferase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
6-phosphogluconate dehydrogenase C-terminal
Neutral/alkaline non-lysosomal ceramidase C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
Anthranilate synthase component I N-terminal
Glycosyl transferase family 3 N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Plays an important role in substrate specificity
Peptidase M1 membrane alanine aminopeptidase
Essential for prephenate dehydratase activity
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal