Major facilitator superfamily (MFS) profile
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Plays an important role in substrate specificity
Polysaccharide chain length determinant N-terminal
Membrane fusion protein biotin-lipoyl like
RND efflux pump membrane fusion protein barrel-sandwich
Outer membrane protein beta-barrel domain-containing protein
CobB/CobQ-like glutamine amidotransferase
Oxidoreductase molybdopterin-binding domain-containing protein
DNA mismatch repair proteins mutS family
TonB-dependent receptor-like beta-barrel
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Bacterial type II secretion system protein E
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Large ribosomal subunit protein uL2 C-terminal
Peptidase M1 membrane alanine aminopeptidase
Glycoside hydrolase GH146 substrate-binding
Glycoside hydrolase GH146 substrate-binding domain-containing protein
Soil-associated protein, TIGR03435 family
PBS lyase HEAT domain protein repeat-containing protein
Glycosyltransferase subfamily 4-like N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Ribosomal RNA adenine methylase transferase N-terminal
3-keto-disaccharide hydrolase domain-containing protein
Membrane iron-sulfur containing protein FtrD-like
Could be important to modulate the pK values of the two catalytic cysteine residues
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Transposase IS116/IS110/IS902 C-terminal
RNA polymerase sigma factor 70 region 4 type 2
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Glycoside hydrolase family 57 N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Tryptophan synthase beta chain-like PALP
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Cytochrome c-552/4 domain-containing protein
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Cytochrome C biogenesis protein transmembrane
Thiol:disulfide interchange protein DsbD N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Abnormal spindle-like microcephaly-associated protein ASH
Abnormal spindle-like microcephaly-associated protein ASH domain-containing protein
Peptidase S9 prolyl oligopeptidase catalytic
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
CagE TrbE VirB component of type IV transporter system central
Transition state stabilizer; via amide nitrogen
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
YMGG-like Gly-zipper domain-containing protein
Pyruvate dehydrogenase E1 component middle
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Aminoacyl-transfer RNA synthetases class-II family profile
Alginate export domain-containing protein
O-(5'-phospho-DNA)-tyrosine intermediate
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Putative adhesin domain-containing protein
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
NGG1p interacting factor 3 protein, NIF3
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Glycine cleavage T-protein C-terminal barrel
General stress protein FMN-binding split barrel
Alpha galactosidase C-terminal beta sandwich
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Two component regulator propeller domain protein
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Heme-copper oxidase subunit III family profile
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Probable endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Terminase large subunit-like endonuclease
Phosphoribosylformylglycinamidine synthase linker
Type IV secretion system coupling protein TraD DNA-binding
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Glycoside hydrolase family 31 N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Alpha-D-phosphohexomutase alpha/beta/alpha
Peptide methionine sulphoxide reductase MsrA
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Alpha glucuronidase N-terminal domain-containing protein
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Photosynthesis system II assembly factor Ycf48/Hcf136-like
1,4-alpha-glucan branching enzyme C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Resolvase/invertase-type recombinase catalytic
Phosphoadenosine phosphosulphate reductase
Gfo/Idh/MocA-like oxidoreductase bacterial type C-terminal
Solute-binding protein family 3/N-terminal
Solute-binding protein family 3/N-terminal domain-containing protein
Outer membrane lipoprotein carrier protein LolA
THAP4-like heme-binding beta-barrel domain-containing protein
Important for interaction with partner proteins
TonB C-terminal domain-containing protein
Pyridoxamine 5'-phosphate oxidase putative
Biopterin-dependent aromatic amino acid hydroxylase family profile
Cytochrome oxidase subunit II copper A binding
Myo-inositol-1-phosphate synthase GAPDH-like
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Translation elongation factor P/YeiP central
Peptidase M10A and M12B matrixin and adamalysin
Histidine-specific methyltransferase SAM-dependent
Pyrimidine nucleoside phosphorylase C-terminal
Flagella basal body P-ring formation protein FlgA C-terminal domain-containing protein
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Twin-arginine translocation pathway signal
Outer membrane lipoprotein-sorting protein
Endoribonuclease L-PSP/chorismate mutase-like
NADH:ubiquinone oxidoreductase 30kDa subunit
RNA 2-O ribose methyltransferase substrate binding
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Rv2525c-like glycoside hydrolase-like domain-containing protein
Interaction with polymerase core subunit RpoC
Helix-hairpin-helix DNA-binding motif class 1
Polymerase/histidinol phosphatase N-terminal
Signal transduction histidine kinase internal region
Increases nucleophilicity of active site Cys
Alanyl-transfer RNA synthetases family profile
Twin-arginine translocation signal domain-containing protein
O-(3'-phospho-DNA)-tyrosine intermediate
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
NIF system FeS cluster assembly NifU N-terminal
Photosynthesis system II assembly factor Ycf48/Hcf136-like domain-containing protein
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Formamidopyrimidine-DNA glycosylase catalytic
Membrane insertase YidC/Oxa/ALB C-terminal
Carboxypeptidase regulatory-like domain-containing protein
Tetrahydrodipicolinate-N-succinyltransferase chain A
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Calcium-dependent phosphoinositide phospholipase C
DNA replication/recombination mediator RecO N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Glycosyltransferase family 28 N-terminal
Ysc84 actin-binding domain-containing protein
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Essential for prephenate dehydratase activity
Nucleophile; cysteine thiosulfonate intermediate
6-phosphogluconate dehydrogenase C-terminal
Polysaccharide biosynthesis protein C-terminal
Putative regulatory protein FmdB Zinc ribbon
Glycosyl transferase family 28 C-terminal
Gamma-butyrobetaine hydroxylase-like N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Alpha-glycerophosphate oxidase C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
Could play a key role in the communication between the regulatory and the substrate sites
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
S-adenosylmethionine-dependent methyltransferase
Metallo-beta-lactamase domain-containing protein
40-residue YVTN family beta-propeller repeat protein
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Exonuclease VII large subunit C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Prepilin type IV endopeptidase peptidase
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Peptide methionine sulfoxide reductase MsrB
Flagellar motor switch protein FliN-like C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Penicillin-binding protein transpeptidase
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal
Chromosomal replication initiator DnaA C-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Beta-hexosaminidase bacterial type N-terminal
Anthranilate synthase component I N-terminal
Glycoside hydrolase family 2 sugar binding protein
Reversibly protonated during proton transport
Shikimate dehydrogenase substrate binding N-terminal
DNA-directed DNA polymerase family A palm
Lysozyme inhibitor LprI N-terminal domain-containing protein
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Alginate lyase domain-containing protein
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Large ribosomal subunit protein uL15/eL18
DNA-directed RNA polymerase RpoA/D/Rpb3-type
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Small ribosomal subunit protein uS4 N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Thiol:disulfide interchange protein DsbD N-terminal domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-112)
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Decreased mandelonitrile cyanolysis activity but complete loss of mandelonitrile synthesis activity and enantioselectivity in vitro. Does not affect metal binding in vitro.
Decreased mandelonitrile cyanolysis activity in vitro. Decreased metal binding in vitro.
Does not affect mandelonitrile synthesis in vitro.
Increases active towards (S)-2-chloromandelonitrile in vitro.
Increases activity towards both enantiomers for 2-chloromandelonitrile in vitro.
Increases catalytic activity and enantioselectivity in vitro; when associated with A-20.
Increases catalytic activity and enantioselectivity in vitro; when associated with L-109.
Increases catalytic activity and enantioselectivity in vitro; when associated with L-3.
Increases catalytic activity and enantioselectivity in vitro; when associated with M-25.
Increases catalytic activity and enantioselectivity in vitro; when associated with Q-36.
Increases catalytic activity and enantioselectivity in vitro; when associated with V-117.
Increases enzymatic activity and enantioselectivity in vitro.
Increases enzymatic activity and enantioselectivity in vitro. Further increases in enzymatic activity and enantioselectivity in vitro; when associated with H-40 and H-110.
Increases enzymatic activity and enantioselectivity in vitro. Further increases in enzymatic activity and enantioselectivity in vitro; when associated with H-40 and T-42.
Increases enzymatic activity and enantioselectivity in vitro. Further increases in enzymatic activity and enantioselectivity in vitro; when associated with T-42 and H-110.
Increases enzymatic activity and enantioselectivity in vitro; when associated with L-29 and A-42.
Increases enzymatic activity and enantioselectivity in vitro; when associated with L-29 and R-36.
Increases enzymatic activity and enantioselectivity in vitro; when associated with R-36 and A-42.
Loss of mandelonitrile cyanolysis and cyanohydrin synthesis activity in vitro. Decreased metal binding in vitro.
Loss of mandelonitrile cyanolysis and cyanohydrin synthesis activity in vitro. Reduced metal binding in vitro.
Partial loss of mandelonitrile synthesis activity in vitro.
Results in a soluble but inactive enzyme in vitro.
Results in an insoluble protein in vitro.
Results in soluble proteins but inactive in vitro.
Lipocalin-like domain-containing protein
Superoxide dismutase copper/zinc binding
Large ribosomal subunit protein uL6 alpha-beta
UDP N-acetylglucosamine O-acyltransferase C-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Oligogalacturonate lyase domain-containing protein
Organic solvent tolerance-like N-terminal
ABC-type glycine betaine transport system substrate-binding
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
SMP-30/Gluconolaconase/LRE-like region-containing protein
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Release factor glutamine methyltransferase N-terminal
Pectate lyase superfamily protein domain-containing protein
Formiminotransferase C-terminal subdomain
Formiminotransferase N-terminal subdomain
Peptidase M1 membrane alanine aminopeptidase domain-containing protein
Putative Flp pilus-assembly TadG-like N-terminal
RNA binding; important for wobble base 34 recognition
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Thioredoxin-like fold domain-containing protein
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
YbaK/aminoacyl-tRNA synthetase-associated
TonB-dependent receptor-like beta-barrel domain-containing protein
Mannose-6-phosphate isomerase type II C-terminal
NfeD-like C-terminal domain-containing protein
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Glycosyl transferase family 3 N-terminal
Positions MEP for the nucleophilic attack
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Bacterial Ig-like domain-containing protein
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Nitrite/Sulfite reductase ferredoxin-like