Aminoacyl-transfer RNA synthetases class-II family profile
Pyruvate phosphate dikinase AMP/ATP-binding
Helix-hairpin-helix DNA-binding motif class 1
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
TRAP C4-dicarboxylate transport system permease DctM subunit
Proteinase inhibitor I42 chagasin domain-containing protein
Pyruvate/ketoisovalerate oxidoreductase catalytic
Alpha-D-phosphohexomutase alpha/beta/alpha
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Large ribosomal subunit protein uL15/eL18
Membrane fusion protein biotin-lipoyl like
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Penicillin-binding protein transpeptidase
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Schiff-base intermediate with acetaldehyde
Schiff-base intermediate with substrate; via pyruvic acid
Cation-transporting P-type ATPase N-terminal
C4-dicarboxylate ABC transporter substrate-binding protein
Pyridoxamine 5'-phosphate oxidase putative
Aspartate/homoserine dehydrogenase NAD-binding
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Bacterial type II secretion system protein E
Endoribonuclease L-PSP/chorismate mutase-like
RNA 2-O ribose methyltransferase substrate binding
Important for autoinhibition of adenylyltransferase activity
Major facilitator superfamily (MFS) profile
Terminase large subunit-like endonuclease
Saccharopine dehydrogenase-like C-terminal
NIF system FeS cluster assembly NifU N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glycosyltransferase subfamily 4-like N-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Sporulation stage II protein D amidase enhancer LytB N-terminal
Mechanosensitive ion channel protein MscS
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Polymerase/histidinol phosphatase N-terminal
General stress protein FMN-binding split barrel
Tryptophan synthase beta chain-like PALP
Phosphoadenosine phosphosulphate reductase
YbaK/aminoacyl-tRNA synthetase-associated
ABC transporter substrate-binding protein PnrA-like
ABC transporter substrate-binding protein PnrA-like domain-containing protein
Survival protein SurE-like phosphatase/nucleotidase
RNA polymerase sigma factor 70 region 4 type 2
Could play a key role in the communication between the regulatory and the substrate sites
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Peptidase S8/S53 domain-containing protein
Small ribosomal subunit protein uS4 N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
RND efflux pump membrane fusion protein barrel-sandwich
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Ada DNA repair metal-binding domain-containing protein
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
TonB-dependent receptor-like beta-barrel
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Translation elongation factor P/YeiP central
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Signal transduction histidine kinase internal region
5-glutamyl coenzyme A thioester intermediate
Septum formation inhibitor MinC C-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Autotransporter domain-containing protein
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
S-adenosyl-L-homocysteine hydrolase NAD binding
Dinitrogenase iron-molybdenum cofactor biosynthesis
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Phosphodiester glycosidase domain-containing protein
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Organic solvent tolerance-like N-terminal domain-containing protein
Peptidase M14 carboxypeptidase A domain-containing protein
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Polysaccharide biosynthesis protein CapD-like
Ribose-phosphate pyrophosphokinase N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Gly-cisPro motif, important for rejection of L-amino acids
Phosphatidylglycerol lysyltransferase C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Sigma 54 modulation/S30EA ribosomal protein C-terminal
EfeO-type cupredoxin-like domain-containing protein
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Glycogen debranching enzyme bacterial and archaeal type N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Choloylglycine hydrolase/NAAA C-terminal
Choloylglycine hydrolase/NAAA C-terminal domain-containing protein
Membrane insertase YidC/Oxa/ALB C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Peptidase C1A papain C-terminal domain-containing protein
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
DNA-directed DNA polymerase family A palm
Could be important to modulate the pK values of the two catalytic cysteine residues
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Prepilin type IV endopeptidase peptidase
Diacylglycerol glucosyltransferase N-terminal
Interaction with polymerase core subunit RpoC
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Trimeric autotransporter adhesin YadA-like C-terminal membrane anchor
Trimeric autotransporter adhesin YadA-like stalk
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Transcription regulator AsnC/Lrp ligand binding
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
ATPsynthase alpha/beta subunit N-terminal extension
S-adenosylmethionine-dependent methyltransferase
NIF system FeS cluster assembly NifU C-terminal
Formiminotransferase C-terminal subdomain
Formiminotransferase N-terminal subdomain
NADH-rubredoxin oxidoreductase C-terminal
Right handed beta helix domain-containing protein
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Cytochrome C biogenesis protein transmembrane
ABC transporter substrate-binding protein
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
RNA binding; important for wobble base 34 recognition
Dienelactone hydrolase domain-containing protein
Solute-binding protein family 3/N-terminal
Tryptophan RNA-binding attenuator protein
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Peptidase C45 hydrolase domain-containing protein
Ysc84 actin-binding domain-containing protein
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Polysaccharide chain length determinant N-terminal
Exonuclease VII large subunit C-terminal
Type II restriction enzyme and methyltransferase RM.Eco57I-like
Pseudouridine synthase I TruA alpha/beta
Gram-positive cocci surface proteins LPxTG domain-containing protein
HicB-like antitoxin of toxin-antitoxin system
Aromatic amino acid beta-eliminating lyase/threonine aldolase
O-(5'-phospho-DNA)-tyrosine intermediate
Prokaryotic-type class I peptide chain release factors
DNA helicase Holliday junction RuvA type
Involved in ionization of N3 of dUMP, leading to its activation
Large ribosomal subunit protein uL6 alpha-beta
Thiamin pyrophosphokinase thiamin-binding
Multifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'-nucleotidase/3'-nucleotidase
CobB/CobQ-like glutamine amidotransferase
Phosphoribosylformylglycinamidine synthase linker
Cucumopine synthase C-terminal helical bundle
Glycosyl transferase family 3 N-terminal
Solute-binding protein family 5 domain-containing protein
Methylaspartate ammonia-lyase C-terminal
Methylaspartate ammonia-lyase N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Essential for prephenate dehydratase activity
Increases nucleophilicity of active site Cys
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Methylguanine DNA methyltransferase ribonuclease-like
AB hydrolase-1 domain-containing protein
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Nucleoside phosphorylase domain-containing protein
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Resolvase/invertase-type recombinase catalytic
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Peptidase C39-like domain-containing protein
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Global transcriptional regulator CodY C-terminal
Global transcriptional regulator CodY N-terminal
Trigger factor ribosome-binding bacterial
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Large ribosomal subunit protein uL2 C-terminal
Proton acceptor; for glutaminase activity
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Transcriptional regulator AbiEi antitoxin N-terminal
Chromosomal replication initiator DnaA C-terminal
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
Alanyl-transfer RNA synthetases family profile
tRNA (guanine-N(1)-)-methyltransferase C-terminal
Heat-inducible transcription repressor HrcA C-terminal
SsuA/THI5-like domain-containing protein
Release factor glutamine methyltransferase N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Trimeric autotransporter adhesin YadA-like head
Trimeric autotransporter adhesin YadA-like head domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Glycine zipper domain-containing protein
Molybdopterin cofactor biosynthesis C (MoaC)
Schiff-base intermediate with D-ribose 5-phosphate
Ribosomal RNA adenine methylase transferase N-terminal